Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey

Kaibori, Masaki; Yoshii, Kengo; Kashiwabara, Kosuke; Kobayashi, Takashi; Hasegawa, Kiyoshi; Izumi, Namiki; Murakami, Takamichi; Kudo, Masatoshi; Shiina, Shuichiro; Sakamoto, Michiie; Nakashima, Osamu; Matsuyama, Yutaka; Eguchi, Susumu; Yamashita, Tatsuya; Takayama, Tadatoshi; Kokudo, Norihiro; Kubo, Shoji

doi:10.1111/hepr.13676

Cited by 6 publications

(8 citation statements)

References 42 publications

(44 reference statements)

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“…There were seven studies with 1181 patients (HCV+ n = 205, HCV- n = 976)[ 11 , 17 - 22 ]. Kaibori et al [ 19 ] performed propensity score matching (PSM) analysis to derive their cohorts; only the PSM cohort was analysed in our study. Uenishi et al [ 20 ] performed univariate and multivariate analyses on the impact of HCV infection on outcomes of surgical resection in cholangiocarcinoma, of which outcomes of the multivariate analysis was included in our study.…”

Section: Resultsmentioning

confidence: 99%

“…There were 2 studies involving 294 patients (HCV+ n = 135, HCV- n = 159) which reported on RFS[ 19 , 20 ]. Meta-analysis was not performed for RFS due to the small sample size and limitations in interpretation.…”

Section: Resultsmentioning

confidence: 99%

“…Meta-analysis was not performed for RFS due to the small sample size and limitations in interpretation. Kaibori et al [ 19 ] reported significantly worse RFS in the HCV+ group (HR 1.61, 95%CI: 1.09, 2.38, P = 0.016) compared to the HCV- group. Uenishi et al [ 20 ] reported comparable RFS between the HCV+ group and HCV- group (HR 1.59, 95%CI: 0.74, 3.41, P = 0.24).…”

Section: Resultsmentioning

confidence: 99%

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Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

Cheo,

Chan,

Shelat

2024

World J Virol

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BACKGROUND Cholangiocarcinoma is the second most common primary liver malignancy. Its incidence and mortality rates have been increasing in recent years. Hepatitis C virus (HCV) infection is a risk factor for development of cirrhosis and cholangiocarcinoma. Currently, surgical resection remains the only curative treatment option for cholangiocarcinoma. We aim to study the impact of HCV infection on outcomes of liver resection (LR) in intrahepatic cholangiocarcinoma (ICC). AIM To study the outcomes of curative resection of ICC in patients with HCV (i.e., HCV+) compared to patients without HCV (i.e., HCV-). METHODS We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies to assess the outcomes of LR in ICC in HCV+ patients compared to HCV- patients in tertiary care hospitals. PubMed, EMBASE, The Cochrane Library and Scopus were systematically searched from inception till August 2023. Included studies were RCTs and non-RCTs on patients ≥ 18 years old with a diagnosis of ICC who underwent LR, and compared outcomes between patients with HCV+ vs HCV-. The primary outcomes were overall survival (OS) and recurrence-free survival. Secondary outcomes include perioperative mortality, operation duration, blood loss, intrahepatic and extrahepatic recurrence. RESULTS Seven articles, published between 2004 and 2021, fulfilled the selection criteria. All of the studies were retrospective studies. Age, incidence of male patients, albumin, bilirubin, platelets, tumor size, incidence of multiple tumors, vascular invasion, bile duct invasion, lymph node metastases, and stage 4 disease were comparable between HCV+ and HCV- group. Alanine transaminase [MD 22.20, 95%confidence interval (CI): 13.75, 30.65, P < 0.00001] and aspartate transaminase levels (MD 27.27, 95%CI: 20.20, 34.34, P < 0.00001) were significantly higher in HCV+ group compared to HCV- group. Incidence of cirrhosis was significantly higher in HCV+ group [odds ratio (OR) 5.78, 95%CI: 1.38, 24.14, P = 0.02] compared to HCV- group. Incidence of poorly differentiated disease was significantly higher in HCV+ group (OR 2.55, 95%CI: 1.34, 4.82, P = 0.004) compared to HCV- group. Incidence of simultaneous hepatocellular carcinoma lesions was significantly higher in HCV+ group (OR 8.31, 95%CI: 2.36, 29.26, P = 0.001) compared to HCV- group. OS was significantly worse in the HCV+ group (hazard ratio 2.05, 95%CI: 1.46, 2.88, P < 0.0001) compared to HCV- group. CONCLUSION This meta-analysis demonstrated significantly worse OS in HCV+ patients with ICC who underwent curative resection compared to HCV- patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

Cheo,

Chan,

Shelat

2024

World J Virol

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“…ICC is a heterogeneous disease, which results from accumulation of genetic and epigenetic alterations in tumor cells, microorganisms, and host immunity 1,32–35 . The mechanisms by which disability in perioperative ADL correlates with recurrence and mortality after resection of ICC are largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Disability in perioperative activities of daily living is associated with worse survival outcomes following hepatic resection in patients with intrahepatic cholangiocarcinoma

Mima

Hayashi

Yumoto

et al. 2022

Hepatology Research

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Aim Intrahepatic cholangiocarcinoma (ICC) is a rare disease; however, its incidence and mortality are increasing worldwide. The rapid aging of populations around the world is leading to an increased number of patients with cancer who develop disability in activities of daily living (ADL). This study was conducted to investigate the associations of perioperative ADL with patient survival after hepatic resection for ICC. Methods We included 70 consecutive patients who underwent hepatectomy for ICC from 2010 to 2021 in the current study. Preoperative and postoperative ADL were evaluated based on the Barthel index, which yields a score of 0–100 points, with higher scores indicating greater independence. A preoperative or postoperative Barthel index score of <100 was defined as disability in perioperative ADL. Cox proportional hazards regression was used to calculate hazard ratios after adjusting for potential confounders. Results Among the 70 patients, seven (10%) had a preoperative Barthel index score of <100, and 23 (33%) showed a postoperative Barthel index score of <100. Multivariate analyses revealed that disability in perioperative ADL was associated with shorter recurrence‐free survival (multivariable hazard ratios 2.38, 95% confidence interval 1.22–4.57; p = 0.011) and overall survival (multivariable hazard ratio 2.49, 95% confidence interval 1.09–5.70; p = 0.031). Conclusions Disability in perioperative ADL is associated with shorter recurrence‐free and overall survival after hepatic resection for ICC. Upon validation, perioperative measurement of ADL may improve risk assessment, and improvement of perioperative ADL may lead to favorable clinical outcomes in patients with ICC.

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“…The Japan Liver Cancer Association (formerly Liver Cancer Study Group of Japan) has worked to advance the study and treatment of liver cancer since 1969, carrying out 22 national surveys on primary liver cancer with institutional members and collaborating institutions across Japan based on its General Rules for the Clinical and Pathological Study of Primary Liver Cancer, 1–11 and publishing the official results of those surveys and original article using this database 12–54 , 55–97 ,. 98–107 The group also reports on the Response Evaluation Criteria in Cancer of the Liver 108–117 . Recently, the Japan Liver Cancer Association also published clinical practice guidelines for intrahepatic cholangitis carcinoma 107…”

Section: Introductionmentioning

confidence: 99%

Report of the 23rd nationwide follow‐up survey of primary liver cancer in Japan (2014–2015)

Iijima,

Kudo,

Kubo

et al. 2023

Hepatology Research

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In the 23rd Nationwide Follow‐up Survey of Primary Liver Cancer in Japan, data from 20,889 newly registered patients and 42,274 previously registered follow‐up patients were compiled from 516 institutions over a 2‐year period from 1 January 2014 to 31 December 2015. Basic statistics compiled for patients newly registered in the 23rd survey was cause of death, past medical history, clinical diagnosis, imaging diagnosis, treatment‐related factors, pathological diagnosis, recurrence status, and autopsy findings. Compared with the previous 22nd survey, the population of patients with hepatocellular carcinoma (HCC) was older at the time of clinical diagnosis, had more female patients, had more patients with non‐B non‐C HCC, had smaller tumor diameter, and was more frequently treated with hepatectomy. Cumulative survival rates were calculated for HCC, intrahepatic cholangiocarcinoma (ICC), and combined hepatocellular cholangiocarcinoma (combined HCC and ICC) by treatment type and background characteristics for patients newly registered between 2004 and 2015 whose final outcome was survival or death. Median overall survival and cumulative survival rates for HCC were calculated by dividing patients by combinations of background factors (number of tumors, tumor diameter, Child‐Pugh grade, or ALBI grade) and by treatment type (hepatectomy, radiofrequency ablation therapy [RFA], transcatheter arterial chemoembolization [TACE], hepatic arterial infusion chemotherapy [HAIC] and systemic therapy). The same values were also calculated according to registration date by dividing patients newly registered between 1978 and 2015 into five time period groups. The data obtained from this nationwide follow‐up survey are expected to contribute to advancing clinical research and treatment of primary liver cancer in the world.This article is protected by copyright. All rights reserved.

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Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey

Cited by 6 publications

References 42 publications

Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

Outcomes of liver resection in hepatitis C virus-related intrahepatic cholangiocarcinoma: A systematic review and meta-analysis

Disability in perioperative activities of daily living is associated with worse survival outcomes following hepatic resection in patients with intrahepatic cholangiocarcinoma

Report of the 23rd nationwide follow‐up survey of primary liver cancer in Japan (2014–2015)

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