Application of nano-carbon and titanium clip combined labeling in robot-assisted laparoscopic transverse colon cancer surgery

Abstract

Background Robot-assisted laparoscopic transverse colon tumor surgery requires precise tumor localization. The purpose of this study was to evaluate the safety and efficacy of nano-carbon and titanium clip combination labeling methods in robot-assisted transverse colon tumor surgery. Methods From January 2018 to January 2019, the clinical data of 16 patients who come from FuZhou, China underwent preoperative nano-carbon and titanium clip combined with robot-assisted laparoscopic transverse colon cancer surgery were retrospectively analyzed. Results Of the 16 patients, no signs of abdominal pain, fever, or diarrhea were observed after colonoscopy. Two titanium clips were seen on all of the 16 patients' abdominal plain films. Nano-carbon staining sites were observed during the operation, and no staining disappeared or abdominal cavity contamination. All patients underwent R0 resection. The average number of lymph nodes harvsted was 18.23 ± 5.04 (range, 9–32). The average time to locate the lesion under the laparoscopic was 3.03 ± 1.26 min (range, 1–6 min), and the average operation time was 321.43 ± 49.23 min (range, 240–400 min). All were consistent with the surgical plan, and there was no intraoperative change of surgical procedure or conversion to open surgery. Conclusion Preoperative colonoscopy combined with nano-carbon and titanium clip is safe and effective in robot-assisted transverse colon cancer surgery. A At the same time, the labeling method shows potential in shortening the operation time, ensuring sufficient safety margin and reducing complications.

Experimental Study on Gastric Labeling by Magnetic Detector Combined With Magnetic Bead

“…Because the diffusion range of staining and marking may be too large, it was often combined with a titanium clip for marking. 22 In this experiment, the titanium clip was used to bind magnetic beads, and the titanium clip itself also plays a positioning role, which can determine the cutting edge during operation. Correctly judging the surgical margin can reduce the positive margin and the need for additional surgical resection.…”

“…Compared with the situation that the diffusion range of dyeing marks is uncertain, magnetic bead marks have the potential for more accurate marking. Because the diffusion range of staining and marking may be too large, it was often combined with a titanium clip for marking 22. In this experiment, the titanium clip was used to bind magnetic beads, and the titanium clip itself also plays a positioning role, which can determine the cutting edge during operation.…”

Advances in nanomedicines for lymphatic imaging and therapy

“…These advantages include: (1) Nanocarriers possess more effective and controllable biological activity and imaging performance, and can improve the solubility, bioavailability, and stability of the delivered drugs through chemical functionalization, hydrophilic-hydrophobic interactions, and electrostatic interactions [ 9 ]; (2) Nanomedicine can improve drug pharmacokinetics and tissue distribution by extending circulation time or preventing rapid clearance by the reticuloendothelial system [ 10 ]; (3) The high surface area of nanomedicine is conducive to more surface modification, and efficient drug surface functionalization can achieve personalized diagnosis and treatment applications; when targeted ligands are surface-modified, targeted tissue or cell enrichment and bioavailability of target lesions can be improved through receptor-ligand interactions [ 11 ]. Based on these advantages of nanomedicine, the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have approved a variety of nanomedicine for the diagnosis, treatment, and imaging recognition of cancer and metastasis, such as nanocarbon and abraxane, et al [ 12 , 13 ], which has a promising future for improving the dilemma of cancer treatment.…”