Association between pesticide exposure and colorectal cancer risk and incidence: A systematic review

Matich, Eryn K.; Laryea, Jonathan A.; Seely, Kathryn A.; Stahr, Shelbie; Su, L. Joseph; Hsu, Ping-Ching

doi:10.1016/j.ecoenv.2021.112327

Cited by 41 publications

(13 citation statements)

References 170 publications

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“…Our group has recently reviewed the effect of the six pesticides examined for CRC [ 19 ]. Trifluralin is an herbicide that interrupts mitosis to prevent root development and is toxic to aquatic life because degradation results in different products.…”

Section: Discussionmentioning

confidence: 99%

“…It was widely used as a soil or space fumigant and is used in areas with high temperatures, which favor the volatilization of the chemical. Carbon disulfide is toxic to humans, but the carcinogenic effect is inconclusive [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…Chemical concentrations were classified into five categories using Jenks natural breaks classification to visualize the distribution and gradients across the state. Following initial exploratory analyses and based on a recent review we conducted on the association between pesticides and CRC [ 19 ], we selected six chemicals for this study. The selected chemicals are commonly used as pesticides and in other agricultural activities.…”

Section: Methodsmentioning

confidence: 99%

“…By investigating the relationship between ambient air concentrations of pesticides and CRC incidence rates, the resulting information could help lead to policies concerning the methods of applying pesticides to reduce the risk of CRC. The investigated chemicals in this study focused on pesticides with known carcinogenic characteristics present in a recent review article that examined the relationship between pesticide exposure and CRC incidence rates [ 19 ]. We hypothesized that aggregated ambient air pesticide concentrations are associated with CRC incidence rates at the county level.…”

Section: Introductionmentioning

confidence: 99%

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Geospatial Assessment of Pesticide Concentration in Ambient Air and Colorectal Cancer Incidence in Arkansas, 2013–2017

Young

Collins

et al. 2022

IJERPH

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Exposure to various agricultural pesticides has been linked to colorectal cancer (CRC), mostly among farmworkers and applicators. Given the potential pesticide drift in ambient air, residents near farmland may be exposed to carcinogenic pesticides even if they are not actively engaged in pesticide application. Pesticide air pollution at the county level was estimated using the 2014 National Air Toxics Assessment. CRC incidence data were acquired from the Arkansas Central Cancer Registry for 2013–2017. We ran ordinary least squares (OLS) regression models, finding significant spatial autocorrelation of residuals for most models. Using geographically weighted regression (GWR) we found age-adjusted CRC incidence rates vary in an increasing west-to-east gradient, with the highest rates in the Arkansas Delta region. A similar gradient was observed in the distribution of the population living below the poverty line and the population percentage of Black people. Significant associations between Trifluralin (crude model only), Carbon Tetrachloride, and Ethylene Dibromide with CRC incidence rates in OLS models only explained 5–7% of the variation and exhibited spatial autocorrelation of residuals. GWR models explained 24–32% (adjusted r2 9–16%) of CRC incidence rate variation, suggesting additional factors may contribute to the association between pesticides and CRC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Geospatial Assessment of Pesticide Concentration in Ambient Air and Colorectal Cancer Incidence in Arkansas, 2013–2017

Young

Collins

et al. 2022

IJERPH

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“…Las gestantes que son expuestas a plaguicidas como los herbicidas e insecticidas producen alteraciones en el feto y posteriormente leucemia linfoblástica aguda y también leucemia mieloide aguda infantil siendo el grupo de riesgo las gestantes con repercusiones en sus futuros hijos (Karalexi et al, 2021); por otro lado los agricultores que están en contacto directo con plaguicidas tienen mayor probabilidad de contraer cáncer colorrectal, se demostró en un estudio realizado con militares que consumían alimentos contaminados (Matich et al, 2021).…”

Section: Discussionunclassified

Riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas: Una revisión sistemática

Mendoza

2021

Pakamuros

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Los seres humanos están expuestos de forma directa e indirecta a diferentes tipos de plaguicidas procedentes de actividades agrícolas, estos plaguicidas por ser tóxicos para la salud humana afectando a los trabajadores agrícolas y residentes cercanos. En ese contexto el objetivo fue analizar el riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas. Se desarrolló mediante una revisión bibliográfica sistemática consultando la base de datos Scienciedirect desde enero a agosto del 2021. Se encontró qué el 52.63% de los artículos científicos estaban relacionados a diferentes tipos de cáncer, el 26.32% a intoxicaciones, el 15.79% a problemas y trastornos mentales y el 5.26% a alteraciones metabólicas y hematológicas, concluyendo que los plaguicidas utilizadas en actividades agrícolas generan en el ser humano un mayor riesgo a tener cáncer de tiroides, tumores, cáncer de pulmón, leucemia linfoblástica/mieloide y cáncer colorrectal, además un mayor riesgo a intoxicaciones por ingestión, inhalación y por vía cutánea siendo mortal muchas veces, también genera un mayor riesgo de retardo del crecimiento y desarrollo en los niños, cefalea intensa, párkinson, preciastrocitoma, meduloblastom y ependimoma, así mismo genera alteraciones del colesterol, hematocito, plaquetas y hemoglobina.

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Ernährung und Darmkrebs

Heikenwälder¹,

Heikenwälder²

2023

Der Moderne Krebs - Lifestyle Und Umweltfaktoren Als Risiko

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Association between pesticide exposure and colorectal cancer risk and incidence: A systematic review

Cited by 41 publications

References 170 publications

Geospatial Assessment of Pesticide Concentration in Ambient Air and Colorectal Cancer Incidence in Arkansas, 2013–2017

Geospatial Assessment of Pesticide Concentration in Ambient Air and Colorectal Cancer Incidence in Arkansas, 2013–2017

Riesgo para la salud humana por exposición a plaguicidas procedente de actividades agrícolas: Una revisión sistemática

Ernährung und Darmkrebs

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