The science behind the wool industry. The importance and value of wool production from sheep

Doyle, Emma; Preston, J. W. V.; McGregor, B. A.; Hynd, P. I.

doi:10.1093/af/vfab005

Cited by 32 publications

(13 citation statements)

References 30 publications

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“…Wool fiber is the external part of the hair follicle, and the quality of wool depends on the density of the hair follicle, as well as the type and size of the hair follicle [ 26 ]. From a genetic viewpoint, the main trait affecting the “quality” and “quantity” of the wool is the follicle density [ 27 ]. This study explored the difference in the wool traits of the Hetian sheep and compared the difference in the skin hair follicle density thereby providing a better analysis of the molecular determinants of these phenotypes.…”

Section: Discussionmentioning

confidence: 99%

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Shi

Liu

et al. 2022

PLoS ONE

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Hetian sheep is a breed of sheep unique to the Hetian area of Xinjiang whose wool is used for producing blankets. Individual differences and hair follicle density are the key factors affecting wool production. Therefore, this study aimed to assess the Hetian sheep having different wool densities to statistically analyze the wool traits and hair follicle parameters. Furthermore, the transcriptome sequencing analysis was performed on the skins with different wool densities. The results showed that wool quantity and total hair follicle density of the high wool density sheep was significantly higher than low wool density sheep. The sheepskin with high wool density was found to grow more and finer wool than sheepskin with low wool density. A total of 1,452 differentially expressed genes were screened from the two sets of samples, including 754 upregulated and 698 downregulated genes. The differentially expressed genes were involved in the TGF-β/BMP and MAPK signaling pathways related to hair growth. Eleven differentially expressed genes belonging to the KAPs and KIFs might affect the fineness of the wool. The key genes, like the TNF, MAP2K2, INHBA, FST, PTPN11, MAP3K7, KIT, and BMPR1A, were found to probably affect the growth and density of the wool. The qPCR verified eight genes related to the MAPK pathway whose gene expression trends were consistent with the transcriptome sequencing results. This study furnishes valuable resources for enhancing the quality and production of wool in the Hetian sheep.

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Section: Discussionmentioning

confidence: 99%

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Shi

Liu

et al. 2022

PLoS ONE

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“…Additionally, certain domestic animals, such as wool sheep, angora rabbits, and yak, are utilized for textile materials [ 1 ]. The wool production of animals holds significant economic value in the development of animal husbandry and the textile industry [ 2 ]. Yak ( Bos grunniens ) is a bovine species, and most yaks live in the Qinghai-Tibet Plateau of China.…”

Section: Introductionmentioning

confidence: 99%

Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak

Zhou,

Wu,

Pei

et al. 2024

BMC Genomics

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Background The hair follicle development process is regulated by sophisticated genes and signaling networks, and the hair grows from the hair follicle. The Tianzhu white yak population exhibits differences in hair length, especially on the forehead and shoulder region. However, the genetic mechanism is still unclear. Isoform sequencing (Iso-seq) technology with advantages in long reads sequencing. Hence, we combined the Iso-seq and RNA-seq methods to investigate the transcript complexity and difference between long-haired yak (LHY) and normal-haired yak (NHY). Results The hair length measurement result showed a significant difference between LHY and NHY on the forehead and the shoulder (P-value < 0.001). The skin samples from the forehead and the shoulder of LHY and NHY were pooled for isoform sequencing (Iso-seq). We obtained numerous long transcripts, including novel isoforms, long non-coding RNA, alternative splicing events, and alternative polyadenylation events. Combined with RNA-seq data, we performed differential isoforms (DEIs) analysis between LHY and NHY. We found that some hair follicle and skin development-related DEIs, like BMP4, KRT2, IGF2R, and COL1A2 in the forehead skin; BMP1, KRT1, FGF5, COL2A1, and IGFBP5 in the shoulder skin. Enrichment analysis revealed that DEIs in both two comparable groups significantly participated in skin and hair follicle development-related pathways, like ECM-receptor interaction, focal adhesion, and PI3K-Akt signaling pathways. The results indicated that the hair follicle development of Tianzhu white yak may influence the hair length difference. Besides, the protein-protein interaction (PPI) network of DEIs showed COL2A1 and COL3A1 exhibited a high degree of centrality, and these two genes were suggested as potential candidates for the hair length growth of Tianzhu white yak. Conclusions The results provided a comprehensive analysis of the transcriptome complexity and identified differential transcripts that enhance our understanding of the molecular mechanisms underlying the variation in hair length growth in Tianzhu white yak.

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“…Its products have excellent properties such as a soft sheen, a pleasant feel, and good drapability. 1 However, due to the scaly structure, wool fabrics without anti-shrinkage treatment shrink violently when mechanically squeezed in a hot and humid environment. Therefore, daily washing will cause severe size shrinkage, thickness increase, elasticity loss, surface structure blurring, and other shrinkage phenomena.…”

Section: Introductionmentioning

confidence: 99%

The effect of a novel catalytic system with Savinase 16L and an organophosphine compound on the shrink-proofing and dyeing properties of wool

Wang,

Duan,

Yao

et al. 2023

New J. Chem.

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The science behind the wool industry. The importance and value of wool production from sheep

Cited by 32 publications

References 30 publications

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak

The effect of a novel catalytic system with Savinase 16L and an organophosphine compound on the shrink-proofing and dyeing properties of wool

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