Kinetics of IgG subclasses and their effects on the incidence of infection after allogeneic hematopoietic stem cell transplantation

Koh, Shiro; Koh, Hideo; Nanno, Satoru; Okamura, Hiroshi; Nakashima, Yasuhiro; Nakamae, Mika; Hirose, Asao; Hino, Masayuki; Nakamae, Hirohisa

doi:10.1016/j.trim.2021.101413

Cited by 1 publication

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“…The above two points may account for normal IgG levels at 1 and 2 months after HSCT in the present study. Acute GVHD had a negative effect on serum IgG ( 46 ). Nevertheless, SR-aGVHD HSCT recipients included in the present study achieved an ORR within 3 months after HSCT and did not experience serious complications, such as serious infections and cGVHD, which may account for normal IgG levels since the third month after HSCT.…”

Section: Discussionmentioning

confidence: 99%

Immune Reconstitution of Patients Who Recovered From Steroid-Refractory Acute Graft-Versus-Host Disease After Basiliximab Treatment

et al. 2022

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We aimed to identify the characteristics of immune reconstitution (IR) in patients who recovered from steroid-refractory acute graft-versus-host disease (SR-aGVHD) after basiliximab treatment. A total of 179, 124, 80, and 92 patients were included in the analysis for IR at 3, 6, 9, and 12 months, respectively, after haploidentical donor hematopoietic stem cell transplantation (HID HSCT). We observed that IR was fastest for monocytes and CD8+ T cells, followed by lymphocytes, CD3+ T cells, and CD19+ B cells and slowest for CD4+ T cells. Almost all immune cell subsets recovered comparably between patients receiving <5 doses and ≥5 doses of basiliximab. Most immune cell subsets recovered comparably between SR-aGVHD patients who recovered after basiliximab treatment and event-free HID HSCT recipients. Patients who recovered from SR-aGVHD after basiliximab treatment experienced satisfactory IR, which suggested that basiliximab may not have prolonged the negative impact on IR in these patients.

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Section: Discussionmentioning

confidence: 99%