Sex differences in cancer risk and outcomes after kidney transplantation

Buxeda, Anna; Redondo-Pachón, Dolores; Pérez‐Sáez, María José; Crespo, Marta; Pascual, Julio

doi:10.1016/j.trre.2021.100625

Cited by 17 publications

(13 citation statements)

References 113 publications

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“…To prevent rejection and recurrence of autoimmunity, potent systemic immunosuppression with a combination of T cell ablation, co-stimulation blockade, calcineurin inhibitors, and mammalian target of rapamycin inhibitors is required [12]. However, chronic immunosuppressive therapy is associated with life-threatening adverse effects such as opportunistic infection, organ toxicity, and neoplasm development [14,15].…”

Section: Micro-and Macroencapsulation Technologies Open New Doors For...mentioning

confidence: 99%

Emerging strategies for beta cell transplantation to treat diabetes

Paez‐Mayorga

Lukin

Emerich³

et al. 2022

Trends in Pharmacological Sciences

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Section: Micro-and Macroencapsulation Technologies Open New Doors For...mentioning

confidence: 99%

Emerging strategies for beta cell transplantation to treat diabetes

Paez‐Mayorga

Lukin

Emerich³

et al. 2022

Trends in Pharmacological Sciences

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“…Furthermore, in sensitivity analyses, we investigated the effects of the continuous factor eGFRcys/eGFRcr on renal prognosis in different sexes separately, and only in women the ratio had a meaningful prognostic value. As sex differences existed in many situations such as cancer risk [ 37 ] and cardiovascular complications [ 38 ] and molecular pathways mediating sex difference in response to kidney injury has been reported [ 39 ], it was reasonable that sex difference was not only due to inappropriate selection of cut-off value, but more likely resulted from greater vulnerability to various accumulated substances of SPS in women than in men.…”

Section: Discussionmentioning

confidence: 99%

Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases

Wang

et al. 2022

BioMed Research International

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Background. Shrunken pore syndrome (SPS) represents selective impairment of kidney filtration of low-molecular-weight molecules between 1 and 30 kDa and has been related to outcomes including morbidity, mortality, and cardiovascular events. However, the prevalence and kidney outcomes of SPS have not been investigated in patients with IgA nephropathy (IgAN) and membranous nephropathy (MN). Methods. We retrospectively collected information of 536 patients including 414 with IgAN and 122 with MN. SPS was mainly defined by cystatin C-based eGFR < 70 % of creatinine-based eGFR using the CAPA-LM equation pairs, while CKD-EPI equations were also employed in sensitivity analyses. Prevalence rate of SPS and its association with end-stage renal disease (ESRD) or severe eGFR decline (≥50% eGFR reduction or doubling of baseline creatinine) were investigated. Results. 44% (8%) patients were identified as possessing SPS using the CAPA-LM definition. ESRD happened in 24 patients during the average follow-up period of 27.7 months. Despite dramatic increase of incidence rate of ESRD for SPS, significant hazard ratio (HR) only existed in IgAN patients after multivariable adjustment (HR: 8.35, 95% CI: 2.10~33.26), but lost significance in sensitivity analyses. 36 patients were determined as having experienced severe eGFR decline after excluding transient creatinine fluctuation. SPS was associated with severe eGFR decline by Kaplan-Meier survival analyses in the overall population as well as the IgAN, MN, male, and female subpopulations, which remained significant in multivariable adjustments in all groups except IgAN. However, only in female patients the association between SPS and eGFR decline remained significant in all the sensitivity analyses. Conclusions. SPS was independently associated with eGFR decline in female patients with IgAN and MN.

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“…The ideal validation cohort consists of melanoma patients with paired samples before and after metastasis, and the transcriptomes are profiled by RNA-seq technology. A minimum requirement is a cohort of gender- and race-matched patients with metastatic and non-metastatic melanoma, considering the gender- [ 71 , 72 ] and racial disparities [ 73 ]. We only found an array-based transcriptomic dataset of metastatic melanoma to validate our method.…”

Section: Discussionmentioning

confidence: 99%

Integration of lncRNAs, Protein-Coding Genes and Pathology Images for Detecting Metastatic Melanoma

Liu

Fan

et al. 2022

Genes

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Melanoma is a lethal skin disease that develops from moles. This study aimed to integrate multimodal data to predict metastatic melanoma, which is highly aggressive and difficult to treat. The proposed EnsembleSKCM method evaluated the prediction performances of long noncoding RNAs (lncRNAs), protein-coding messenger genes (mRNAs) and pathology images (images) for metastatic melanoma. Feature selection was used to screen for metastatic biomarkers in the lncRNA and mRNA datasets. The integrated EnsembleSKCM model was built based on the weighted results of the lncRNA-, mRNA- and image-based models. EnsembleSKCM achieved 0.9444 in the prediction accuracy of metastatic melanoma and outperformed the single-modal prediction models based on the lncRNA, mRNA and image data. The experimental data suggest the importance of integrating the complementary information from the three data modalities. WGCNA was used to analyze the relationship of molecular-level features and image features, and the results show connections between them. Another cohort was used to validate our prediction.

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Sex differences in cancer risk and outcomes after kidney transplantation

Cited by 17 publications

References 113 publications

Emerging strategies for beta cell transplantation to treat diabetes

Emerging strategies for beta cell transplantation to treat diabetes

Shrunken Pore Syndrome Is Associated with Renal Function Decline in Female Patients with Kidney Diseases

Integration of lncRNAs, Protein-Coding Genes and Pathology Images for Detecting Metastatic Melanoma

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