Depletion of CD56+CD3+ invariant natural killer T cells prevents allergen-induced inflammation in humanized mice

Ose, Robert; Weigmann, Benno; Schuppan, Detlef; Waisman, Ari; Saloga, Joachim; Bellinghausen, Iris

doi:10.1016/j.jaci.2021.05.005

Cited by 3 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rapid synthesis of cytokines makes these cells important regulators of inflammatory processes, including allergic processes. It is postulated that γδT and iNKT cells are involved in the development and modulation of the course of allergic diseases ( 30 , 31 , 34 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of immunostimulation with bacterial lysate on the clinical course of allergic rhinitis and the level of γδT, iNKT and cytotoxic T cells in children sensitized to grass pollen allergens: A randomized controlled trial

Janeczek

Kowalska²,

Zarobkiewicz³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

BackgroundThere are many drugs for allergic rhinitis (AR), however, these drugs show variable clinical effectiveness and some side effects. Therefore, new methods of AR pharmacotherapy are being sought.ObjectivesThe objectives of this study were to evaluate the efficacy of polyvalent mechanical bacterial lysate (PMBL) therapy in improving the clinical course of grass pollen-induced AR (seasonal AR, SAR) in children and its effect on changes in the blood level of the γδT, iNKT and cytotoxic T cell subsets.MethodsFifty children with SAR were enrolled in this study and were randomly assigned to either the PMBL group or the placebo group. The severity of SAR symptoms was assessed using the total nasal symptom score (TNSS) and visual analogue scale (VAS). During two visits (V1, V2), peak nasal inspiratory flow (PNIF) was measured and peripheral blood was collected for immunological analyses. The study also included 2 telephone contacts (TC1, TC2).ResultsThe severity of the nasal symptoms of SAR on the TNSS scale was revealed to have a significantly lower impact in the PMBL group vs the placebo group at measuring points TC1 and V2 (p = 0.01, p = 0.009, respectively). A statistically significantly lower mean severity of nasal symptoms of SAR on the VAS scale was recorded for children in the PMBL group compared to the placebo group at measuring points TC1, V2 and TC2 (p = 0.04, p = 0.04, p = 0.03, respectively). The compared groups do not show significant differences in terms of PNIF values at individual measuring points. There were no statistically significant changes in immune variables. For both groups, there was a statistically significant association between the level of Th1-like γδT cells and the severity of SAR symptoms expressed on the TNSS scale (p = 0.03) – the lower the level of Th1-like γδT cells, the higher the TNSS value.ConclusionAdministration of sublingual PMBL tablets during the grass pollen season proves to have a high efficacy in alleviating SAR symptoms in children sensitized to grass pollen allergens. Th1-like γδT cells may be used as potential markers for SAR severity in children.Clinical trial registrationClinicalTrials.gov, identifier (NCT04802616).

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of immunostimulation with bacterial lysate on the clinical course of allergic rhinitis and the level of γδT, iNKT and cytotoxic T cells in children sensitized to grass pollen allergens: A randomized controlled trial

Janeczek

Kowalska²,

Zarobkiewicz³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Humanized mouse models have been proposed to study the complexity of the immune response subsiding allergic diseases, avoiding the ethical constraints inherent to function studies on humans (128). In the context of the plausible pathogenic role of NKT cells in allergic asthma, Ose et al (2021) evidenced that a challenge with either birch or grass pollen allergens on NSG mice that had received CD56-depleted PBMCs obtained from highly sensitized donors led to diminished production of allergen-specific IgE and reduced lung inflammation (129). Furthermore, pathologic airway resistance level and goblet cell hyperplasia were restored when NSG-SGM3 mice expressing human IL-3, GM-CSF, and stem cell factor received CD56-depleted PBMCs concomitantly with positively selected CD3 + CD56 + iNKT cells.…”

Section: Outlining the Role Of Inkt Cells In Asthmatic Disease On Ani...mentioning

confidence: 99%

Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies

Gutiérrez-Vera,

García-Betancourt,

Palacios

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Allergic asthma has emerged as a prevalent allergic disease worldwide, affecting most prominently both young individuals and lower-income populations in developing and developed countries. To devise effective and curative immunotherapy, it is crucial to comprehend the intricate nature of this condition, characterized by an immune response imbalance that favors a proinflammatory profile orchestrated by diverse subsets of immune cells. Although the involvement of Natural Killer T (NKT) cells in asthma pathology is frequently implied, their specific contributions to disease onset and progression remain incompletely understood. Given their remarkable ability to modulate the immune response through the rapid secretion of various cytokines, NKT cells represent a promising target for the development of effective immunotherapy against allergic asthma. This review provides a comprehensive summary of the current understanding of NKT cells in the context of allergic asthma, along with novel therapeutic approaches that leverage the functional response of these cells.

show abstract

PD-1/PD-L1 interaction score and NKT-like cell infiltration predict immunotherapy efficacy in non-small cell lung cancer patients

Zhang,

Lin,

et al. 2024

Cytotherapy

View full text Add to dashboard Cite

Depletion of CD56+CD3+ invariant natural killer T cells prevents allergen-induced inflammation in humanized mice

Cited by 3 publications

References 26 publications

Effect of immunostimulation with bacterial lysate on the clinical course of allergic rhinitis and the level of γδT, iNKT and cytotoxic T cells in children sensitized to grass pollen allergens: A randomized controlled trial

Effect of immunostimulation with bacterial lysate on the clinical course of allergic rhinitis and the level of γδT, iNKT and cytotoxic T cells in children sensitized to grass pollen allergens: A randomized controlled trial

Natural killer T cells in allergic asthma: implications for the development of novel immunotherapeutical strategies

PD-1/PD-L1 interaction score and NKT-like cell infiltration predict immunotherapy efficacy in non-small cell lung cancer patients

Contact Info

Product

Resources

About