2021
DOI: 10.1016/j.jaci.2021.05.005
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Depletion of CD56+CD3+ invariant natural killer T cells prevents allergen-induced inflammation in humanized mice

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Cited by 3 publications
(2 citation statements)
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“…Rapid synthesis of cytokines makes these cells important regulators of inflammatory processes, including allergic processes. It is postulated that γδT and iNKT cells are involved in the development and modulation of the course of allergic diseases ( 30 , 31 , 34 ).…”
Section: Discussionmentioning
confidence: 99%
“…Rapid synthesis of cytokines makes these cells important regulators of inflammatory processes, including allergic processes. It is postulated that γδT and iNKT cells are involved in the development and modulation of the course of allergic diseases ( 30 , 31 , 34 ).…”
Section: Discussionmentioning
confidence: 99%
“…Humanized mouse models have been proposed to study the complexity of the immune response subsiding allergic diseases, avoiding the ethical constraints inherent to function studies on humans (128). In the context of the plausible pathogenic role of NKT cells in allergic asthma, Ose et al (2021) evidenced that a challenge with either birch or grass pollen allergens on NSG mice that had received CD56-depleted PBMCs obtained from highly sensitized donors led to diminished production of allergen-specific IgE and reduced lung inflammation (129). Furthermore, pathologic airway resistance level and goblet cell hyperplasia were restored when NSG-SGM3 mice expressing human IL-3, GM-CSF, and stem cell factor received CD56-depleted PBMCs concomitantly with positively selected CD3 + CD56 + iNKT cells.…”
Section: Outlining the Role Of Inkt Cells In Asthmatic Disease On Ani...mentioning
confidence: 99%