Arterial hypertension

Brouwers, Sofie; Sudano, Isabella; Kokubo, Yoshihiro; Sulaica, Elisabeth M

doi:10.1016/s0140-6736(21)00221-x

Cited by 113 publications

(55 citation statements)

References 103 publications

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“…To that end, significant changes in BP in the invasive reference data were selected and compared to their corresponding PPG-derived BP changes. By concatenating all selected ∆BP inv changes and their corresponding ∆BP PPG values for all 40 patients in vectors U and V respectively, the parameters ̂ of the model were optimized in the least-square sense, i.e., by solving ̂ = argmin ‖U − V‖ 2 . The thus trained model was then applied, with no further adaptation, to the smartphone-derived PPG data in the present study.…”

Section: Algorithm Parameters Trainingmentioning

confidence: 99%

“…Worldwide, hypertension is one of the largest contributor to heart disease and stroke and the leading risk factor responsible for ten million premature deaths [1,2]. With a current trend showing an increase of > 500 million people since the 1970s, prevalence is expected to increase to 1.56 billion worldwide by 2025 [3], driven largely in low and middle-income countries (LMIC) [4].…”

Section: Introductionmentioning

confidence: 99%

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A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter

Hofmann

Proença

Degott

et al. 2022

J Clin Monit Comput

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Smartphones may provide a highly available access to simplified hypertension screening in environments with limited health care resources. Most studies involving smartphone blood pressure (BP) apps have focused on validation in static conditions without taking into account intraindividual BP variations. We report here the first experimental evidence of smartphone-derived BP estimation compared to an arterial catheter in a highly dynamic context such as induction of general anesthesia. We tested a smartphone app (OptiBP) on 121 patients requiring general anesthesia and invasive BP monitoring. For each patient, ten 1-min segments aligned in time with ten smartphone recordings were extracted from the continuous invasive BP. A total of 1152 recordings from 119 patients were analyzed. After exclusion of 2 subjects and rejection of 565 recordings due to BP estimation not generated by the app, we retained 565 recordings from 109 patients (acceptance rate 51.1%). Concordance rate (CR) and angular CR demonstrated values of more than 90% for systolic (SBP), diastolic (DBP) and mean (MBP) BP. Error grid analysis showed that 98% of measurement pairs were in no- or low-risk zones for SBP and MBP, of which more than 89% in the no-risk zone. Evaluation of accuracy and precision [bias ± standard deviation (95% limits of agreement)] between the app and the invasive BP was 0.0 ± 7.5 mmHg [− 14.9, 14.8], 0.1 ± 2.9 mmHg [− 5.5, 5.7], and 0.1 ± 4.2 mmHg [− 8.3, 8.4] for SBP, DBP and MBP respectively. To the best of our knowledge, this is the first time a smartphone app was compared to an invasive BP reference. Its trending ability was investigated in highly dynamic conditions, demonstrating high concordance and accuracy. Our study could lead the way for mobile devices to leverage the measurement of BP and management of hypertension.

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Section: Algorithm Parameters Trainingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter

Hofmann

Proença

Degott

et al. 2022

J Clin Monit Comput

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“…In resting cells, those channels are usually closed; opening those channels allows the entry of calcium ions according with their electrochemical gradient. CCBs exert their antihypertensive effect inhibiting external calcium-evocated contraction in depolarized arteries [ 110 ]. The anti-fertility effects of CCBs have been evaluated both in vitro and in vivo [ 111 ].…”

Section: Metabolic Syndrome and Drugs: Fertility Issuesmentioning

confidence: 99%

Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

Salvio¹,

Ciarloni²,

Cutini³

et al. 2022

IJMS

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Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.

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“…Globally, elevated systolic blood pressure has been estimated to account for 7.7 to 10.4 million annual deaths (Zhou et al 2021 ), which is outnumbered by the number of deaths due to any cardiovascular disease, including ischemic heart disease, estimated to 18.6 million cases for the year 2019 (Roth et al 2020 ). Drugs to inhibit vascular smooth muscle contraction belong to the gold standard options in medical treatment of hypertension and cardiovascular diseases (Brouwers et al 2021 ). Diabetic nephropathy represents a major complication of diabetes, affecting 17–35% of patients with diabetes and accounting for 50% of patients entering dialysis or programs for kidney transplantation in the USA (DeFronzo et al 2021 ; Lin et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729

Huang

Tamalunas

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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NAV2729 is a presumed inhibitor of the monomeric GTPase ADP ribosylation factor 6 (ARF6) and inhibits smooth muscle contraction outside the cardiovascular system. Its effects on vascular smooth muscle contraction or a possible role of ARF6 in vasocontraction have not yet been examined. Here, we report effects of NAV2729 on neurogenic and agonist-induced contractions in renal interlobar and coronary arteries. Contractions of pig interlobar and coronary arteries were induced in an organ bath by agonists or by electric field stimulation (EFS). Owing to divergent characteristics of both vessel types, EFS-induced contractions were only examined in interlobar arteries, and contractions by agonists acting on muscarinic receptors only in coronary arteries. NAV2729 inhibited frequency-dependent EFS-induced contractions of interlobar arteries. The degree of inhibition was similar using 5 µM and 10 µM NAV2729. Inhibition of EFS-induced contractions was resistant to a nitric oxide synthase inhibitor and to diclofenac. The neurogenic and adrenergic character of EFS-induced contractions was confirmed by inhibition by tetrodotoxin and prazosin. In coronary arteries, NAV2729 (5 µM) inhibited concentration-dependent contractions induced by carbachol and methacholine. Contractions induced by α1-adrenergic agonists, endothelin-1, the thromboxane receptor agonist U46619, or serotonin remained unchanged by NAV2729 in both vessel types. NAV2729 inhibits neurogenic contractions in interlobar arteries and contractions induced by cholinergic agonists in coronary arteries. In both vessel types, NAV2729 does not inhibit contractions induced by receptor agonists other than those acting on muscarinic receptors. Addressing effects in other vessels and in other smooth muscle–rich organs merits further attention.

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Arterial hypertension

Cited by 113 publications

References 103 publications

A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter

A novel smartphone app for blood pressure measurement: a proof-of-concept study against an arterial catheter

Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a Complex Cardiometabolic Endocrinopathy

Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729

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