2021
DOI: 10.1186/s12979-021-00237-w
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The age again in the eye of the COVID-19 storm: evidence-based decision making

Abstract: Background One hundred fifty million contagions, more than 3 million deaths and little more than 1 year of COVID-19 have changed our lives and our health management systems forever. Ageing is known to be one of the significant determinants for COVID-19 severity. Two main reasons underlie this: immunosenescence and age correlation with main COVID-19 comorbidities such as hypertension or dyslipidaemia. This study has two aims. The first is to obtain cut-off points for laboratory parameters that c… Show more

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Cited by 9 publications
(7 citation statements)
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References 60 publications
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“…Age-related features of COVID-19 cytokine profiles and immune responses have been observed by our study and in other studies [ 54 56 ]. We detected different levels of serum IL-6, IL-2R, albumin, D-dimer, and C-reactive protein between young and older patients (Fig.…”
Section: Discussionsupporting
confidence: 88%
“…Age-related features of COVID-19 cytokine profiles and immune responses have been observed by our study and in other studies [ 54 56 ]. We detected different levels of serum IL-6, IL-2R, albumin, D-dimer, and C-reactive protein between young and older patients (Fig.…”
Section: Discussionsupporting
confidence: 88%
“…Conversely to clinical forms of COVID-19 [14,15] neither age nor sex have an influence on the probability to develop an asymptomatic COVID-19 infection in our cohort. Several smaller seroprevalence reports from European countries support this feature [16-20].…”
Section: Discussioncontrasting
confidence: 69%
“…Mature age would determine a longer antibody half-life [ 19 ]. Ageing is one of the most important determinants in COVID-19 severity [ 20 , 21 ], and it would have a role as well in humoral response keeping. The oldest patients are known to show both more severe forms of the disease and higher neutralizing activity indeed moderate correlations between age and neutralization have been reported, together with cytokine correlations [ 6 ].…”
Section: Discussionmentioning
confidence: 99%