The role of soy plant-based formula supplemented with dietary fiber to support children's growth and development: An expert opinion

Vandenplas, Yvan; Hegar, Badriul; Munasir, Zakiudin; Astawan, Made; Juffrie, Mohammad; Bardosono, Saptawati; Sekartini, Rini; Basrowi, Ray Wagiu; Wasito, Erika

doi:10.1016/j.nut.2021.111278

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…Lectins in soy formula bind bovine MEX and prevent their absorption in healthy adults [ 459 ]. Thus, breastfeeding combined with soy-based complementary formula may impair the intestinal MEX miR uptake of the infant, which is of concern, as soy-based formula has been advocated as a substitute for infants with cow milk allergy [ 460 , 461 ]. Soy formula may thus interfere with MEX uptake and MEX miR signaling, which are important for allergy prevention [ 19 , 462 , 463 ].…”

Section: Perinatal Factors Disturbing Mex Mir-regulated β Cell Homeos...mentioning

confidence: 99%

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Melnik

Schmitz

2022

IJMS

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Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients provided by human milk. As shown recently, exosomes derived from various origins interact with β cells. This review elucidates the potential role of milk-derived exosomes (MEX) and their microRNAs (miRs) on pancreatic β cell programming during the postnatal period of lactation as well as during continuous cow milk exposure of adult humans to bovine MEX. Mechanistic evidence suggests that MEX miRs stimulate mTORC1/c-MYC-dependent postnatal β cell proliferation and glycolysis, but attenuate β cell differentiation, mitochondrial function, and insulin synthesis and secretion. MEX miR content is negatively affected by maternal obesity, gestational diabetes, psychological stress, caesarean delivery, and is completely absent in infant formula. Weaning-related disappearance of MEX miRs may be the critical event switching β cells from proliferation to TGF-β/AMPK-mediated cell differentiation, whereas continued exposure of adult humans to bovine MEX miRs via intake of pasteurized cow milk may reverse β cell differentiation, promoting β cell de-differentiation. Whereas MEX miR signaling supports postnatal β cell proliferation (diabetes prevention), persistent bovine MEX exposure after the lactation period may de-differentiate β cells back to the postnatal phenotype (diabetes induction).

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Section: Perinatal Factors Disturbing Mex Mir-regulated β Cell Homeos...mentioning

confidence: 99%

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Melnik

Schmitz

2022

IJMS

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“…Given that HM possesses a much stronger antioxidant potential than bovine infant formulas [ 13 ] and the reported antioxidant depletion among preterm or septic neonates, this study aimed to analyze the impact of HM feeding on lung protection or type of mechanical ventilation in neonates with sepsis. Since a recent Cochrane provides only low-certainty evidence about the effects of feeding preterm infants hydrolysate [ 14 ], and a very recent consensus document accepts that there is no data to support soy formula use in preterm infants [ 15 ], our study is limited to analyzing the role of bovine infant formulas.…”

Section: Introductionmentioning

confidence: 99%

Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy

Moliner

Sotto

Leiva³

et al. 2022

Children

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Background. It has been well established that human milk feeding contributes to limiting lung diseases in vulnerable neonates. The primary aim of this study was to compare the need for mechanical ventilation between human milk-fed neonates with sepsis and formula-fed neonates with sepsis. Methods. All late preterm and full-term infants from a single center with sepsis findings from 2002 to 2017 were identified. Data on infant feeding during hospital admission were also recorded. Multivariate logistic regression analyses were performed to assess the impact of feeding type on ventilation support and main neonatal morbidities. Results. The total number of participants was 322 (human milk group = 260; exclusive formula group = 62). In the bivariate analysis, 72% of human milk-fed neonates did not require oxygen therapy or respiratory support versus 55% of their formula-fed counterparts (p < 0.0001). Accordingly, invasive mechanical ventilation was required in 9.2% of any human milk-fed infants versus 32% of their exclusively formula-fed counterparts (p = 0.0085). These results held true in multivariate analysis; indeed, any human milk-fed neonates were more likely to require less respiratory support (OR = 0.44; 95% CI:0.22, 0.89) than those who were exclusively formula-fed. Conclusion. Human milk feeding may minimize exposure to mechanical ventilation.

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“…From a nutritional point of view, this value of fiber might be helpful in terms of maintaining positive effect on intestine and colon physiology, besides other homeostatic and therapeutic functions in human nutrition [ 32 ]. Dietary fiber is known to have beneficial health effects, relieving functional constipation, a common gastrointestinal problem in children [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

Characterization of Nutritional and Bioactive Compound in Three Genotypes of Mashua (Tropaeolum tuberosum Ruiz and Pavón) from Different Agroecological Areas in Puno

Coloma

Mamani

Quille-Calizaya

et al. 2022

International Journal of Food Science

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Bioactive compounds and nutritional characterization in three genotypes of mashua tubers (Tropaeolum tuberosum Ruiz and Pavón) from different agroecological areas of the Peruvian highlands (3747 at 3888 meters above sea level) were studied. The studied genotypes from different agroecological areas significantly differed for vitamins, amino acids, and bioactive compounds. However, the nutritional characteristics of yellow, purple, and yellow-purple mashua remained unaffected. Its tubers were shown to be important sources of protein and fiber. The nutritional analysis revealed high phosphorus and potassium values, as well as considerable amounts of vitamin C. The amounts of total free amino acids in the genotypes ranged from 2.73 ± 0.450 mg/g dry matter (DM) to 6.825 ± 0.450 mg/g DM. Important total anthocyanins, total flavonoids, total phenolics, tannin content, and antioxidant activity values were obtained from purple genotype. Unexploited colored mashua tubers are proposed as a valuable natural source of phenolics and anthocyanins with high antioxidant activity.

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The role of soy plant-based formula supplemented with dietary fiber to support children's growth and development: An expert opinion

Cited by 10 publications

References 36 publications

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Milk Exosomal microRNAs: Postnatal Promoters of β Cell Proliferation but Potential Inducers of β Cell De-Differentiation in Adult Life

Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy

Characterization of Nutritional and Bioactive Compound in Three Genotypes of Mashua (Tropaeolum tuberosum Ruiz and Pavón) from Different Agroecological Areas in Puno

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