Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses

Hollmann, Axel; Cardoso, Nancy Patricia; Espeche, Juan Carlos; Maffía, Paulo César

doi:10.1016/j.peptides.2021.170570

Cited by 11 publications

(9 citation statements)

References 96 publications

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“…Severe acute respiratory syndrome (SARS) is a viral respiratory disease induced by SARS-associated coronavirus (SARS-CoV) which affected Asia, North America, and Europe in 2002-2003 [12]. In late 2019, a new type of coronavirus called SARS-CoV-2 caused a viral pandemic known as Coronavirus disease (COVID-19), which led to severe respiratory problems.…”

Section: Covid-19mentioning

confidence: 99%

“…While the holistic perspective on health has existed for some time, practical implementation proves intricate, as observed in the significant increase in infectious disease outbreaks attributed to animal viruses. Coupled with the resurgence of severe bacterial infections resulting from the currently developed antibiotic resistance, these challenges contribute to a growing number of epidemic outbreaks and novel pandemic scenarios [11][12][13]. Despite the crucial priority of diagnosing and predicting outbreaks, the absence of effective antiviral vaccines and therapeutics remains a significant concern.…”

Section: Introductionmentioning

confidence: 99%

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Milk Antiviral Proteins and Derived Peptides against Zoonoses

Santos,

Silva,

Grácio

et al. 2024

IJMS

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Milk is renowned for its nutritional richness but also serves as a remarkable reservoir of bioactive compounds, particularly milk proteins and their derived peptides. Recent studies have showcased several robust antiviral activities of these proteins, evidencing promising potential within zoonotic viral diseases. While several publications focus on milk’s bioactivities, antiviral peptides remain largely neglected in reviews. This knowledge is critical for identifying novel research directions and analyzing potential nutraceuticals within the One Health context. Our review aims to gather the existing scientific information on milk-derived antiviral proteins and peptides against several zoonotic viral diseases, and their possible mechanisms. Overall, in-depth research has increasingly revealed them as a promising and novel strategy against viruses, principally for those constituting a plausible pandemic threat. The underlying mechanisms of the bioactivity of milk’s proteins include inhibiting viral entry and attachment to the host cells, blocking replication, or even viral inactivation via peptide–membrane interactions. Their marked versatility and effectiveness stand out compared to other antiviral peptides and can support future research and development in the post-COVID-19 era. Overall, our review helps to emphasize the importance of potentially effective milk-derived peptides, and their significance for veterinary and human medicines, along with the pharmaceutical, nutraceutical, and dairy industry.

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Section: Covid-19mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Santos,

Silva,

Grácio

et al. 2024

IJMS

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“…Several antiviral peptides have been previously reported, including anti-neurovirulent enterovirus A71 peptide SP40 ( Lalani, Gew, & Poh, 2021 ), anti-influenza virus peptide M2 AH ( Jung et al, 2019 ), and anti-Japanese encephalitis virus peptide P1 ( Yu et al, 2021 ). Antiviral peptides that exhibit anti-coronavirus activity have also been reported, such as antiviral peptides (AVPs) reported by ( Hollmann, Cardoso, Espeche, & Maffía, 2021 ) and antiviral peptide P9R ( Zhao et al, 2020 ). Furthermore, a recent study has shown that in silico hydrolysis of gastrointestinal enzymes in marine fish generates active peptides.…”

Section: Introductionmentioning

confidence: 99%

Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2

Zhao

et al. 2022

LWT

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COVID-19 is a global health emergency that causes serious concerns. A global effort is underway to identify drugs for the treatment of COVID-19. One possible solution to the present problem is to develop drugs that can inhibit SARS-CoV-2 main protease (M pro ), a coronavirus protein that been considered as one among many drug targets. In this work, lactoferrin from Bos taurus L. was in silico hydrolyzed. The bioactivity, water solubility, and ADMET properties of the generated peptides were predicted using various online tools. The molecular interactions between M pro and the peptides were studied using molecular docking and molecular dynamic simulation. The results demonstrated that peptide GSRY was predicted to have better physicochemical properties, and the value of ‘-C DOCKER interaction energy’ between peptide GSRY and M pro was 80.8505 kcal/mol. The interaction between the peptide GSRY and the native ligand N3 co-crystallized with M pro had overlapped amino acids, i.e., HIS163, GlY143, GLU166, GLN189 and MET165. Molecular dynamic simulation revealed that M pro /GSRY complexes were stable. Collectively, the peptide GSRY may be a potential candidate drug against M pro of SARS-CoV-2.

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“…Regarding antimicrobial performance, antifungal and antiviral activity are of particular interest due to difficulties in the development of safe, low molecular weight antibiotics against such targets [ 13 , 14 , 15 , 16 , 17 ]. The penetration inside cells also belongs to the coveted multifunctional property, firstly for the ability of cell-penetrating peptides (CPP) to interact with the cellular membrane in a non-invasive manner [ 18 , 19 ], and secondly for acting on hard-to-reach intracellular targets [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Designed Multifunctional Peptides for Intracellular Targets

Juretić

2022

Antibiotics

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Nature’s way for bioactive peptides is to provide them with several related functions and the ability to cooperate in performing their job. Natural cell-penetrating peptides (CPP), such as penetratins, inspired the design of multifunctional constructs with CPP ability. This review focuses on known and novel peptides that can easily reach intracellular targets with little or no toxicity to mammalian cells. All peptide candidates were evaluated and ranked according to the predictions of low toxicity to mammalian cells and broad-spectrum activity. The final set of the 20 best peptide candidates contains the peptides optimized for cell-penetrating, antimicrobial, anticancer, antiviral, antifungal, and anti-inflammatory activity. Their predicted features are intrinsic disorder and the ability to acquire an amphipathic structure upon contact with membranes or nucleic acids. In conclusion, the review argues for exploring wide-spectrum multifunctionality for novel nontoxic hybrids with cell-penetrating peptides.

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Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses

Cited by 11 publications

References 96 publications

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Milk Antiviral Proteins and Derived Peptides against Zoonoses

Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2

Designed Multifunctional Peptides for Intracellular Targets

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