34.3 An 8.2mm<sup>3</sup> Implantable Neurostimulator with Magnetoelectric Power and Data Transfer

Yu, Zhanghao; Chen, Joshua; Avants, Benjamin W.; He, Yan; Singer, Amanda; Robinson, Jacob T.; Yang, Kaiyuan

doi:10.1109/isscc19947.2020.9062931

Cited by 26 publications

(32 citation statements)

References 7 publications

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“…A custom magnetic field transmitter enables data and power transfer at centimeter depths within safety limits: To deliver data and power to the implant we designed a magnetic field transmitter that drives a high-frequency biphasic current into a resonant coil [38]. By maintaining transmitter power levels below 1W, we can achieve field strengths of > 1mT sufficient to power the ME-BIT at depths of 4 cm within the safety limits.…”

Section: Resultsmentioning

confidence: 99%

“…While the implant itself might only move a few millimeters once fixed within the tissue, it is easy to imagine misaligning a wearable transmitter by a centimeter or more, which remains within our alignment tolerances. Furthermore, the use of a wearable transmitter is also possible due to the low magnetic field strengths that are required to activate high voltages in these ME thin films where only ~1 mT field strengths are required for the power densities required to activate neurons through stimulation by the material itself [35] or by powering custom integrated circuits [38,39]. This will allow the technology to be readily translated into the clinic and even permit patients to use implants at a home-setting.…”

Section: Discussionmentioning

confidence: 99%

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Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Chen

Kan

et al. 2021

Preprint

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Implanted bioelectronic devices have the potential to treat disorders that are resistant to traditional pharmacological therapies; however, reaching many therapeutic nerve targets requires invasive surgeries and implantation of centimeter-sized devices. Here we show that it is possible to stimulate peripheral nerves from within blood vessels using a millimeter-sized wireless implant. By directing the stimulating leads through the blood vessels we can target specific nerves that are difficult to reach with traditional surgeries. Furthermore, we demonstrate this endovascular nerve stimulation (EVNS) with a millimeter sized wireless stimulator that can be delivered minimally invasively through a percutaneous catheter which would significantly lower the barrier to entry for neuromodulatory treatment approaches because of the reduced risk. This miniaturization is achieved by using magnetoelectric materials to efficiently deliver data and power through tissue to a digitally-programmable 0.8 mm2 CMOS system-on-a-chip. As a proof-of-principle we show wireless stimulation of peripheral nerve targets both directly and from within the blood vessels in rodent and porcine models. The wireless EVNS concept described here provides a path toward minimally invasive bioelectronics where mm-sized implants combined with endovascular stimulation enable access to a number of nerve targets without open surgery or implantation of battery-powered pulse generators.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Chen

Kan

et al. 2021

Preprint

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“…The proof-of-concept experiments here are intended to show that ME materials provide an effective wireless power solution for miniature neural stimulators, but their performance and application space can be greatly expanded by adding application specific integrated circuits (ASICs). With these more complex circuits one could create biphasic stimulation using a single ME film or generate wirelessly programmable stimulation at various specified voltage levels (Yu et al 2020). Additionally, one can imagine networks of devices that can be individually addressed using wireless network protocols implemented in the ASICs.…”

Section: Discussionmentioning

confidence: 99%

Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies

Wickens

Avants

Verma

et al. 2018

Preprint

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A fundamental challenge for bioelectronics is to deliver power to miniature devices inside the body. Wires are common failure points and limit device placement. On the other hand, wireless power by electromagnetic or ultrasound waves must overcome absorption by the body and impedance mismatches between air, bone, and tissue. In contrast, magnetic fields suffer little absorption by the body or differences in impedance at interfaces between air, bone, and tissue. These advantages have led to magneticallypowered stimulators based on induction or magnetothermal effects. However, fundamental limitations in these power transfer technologies have prevented miniature magnetically-powered stimulators from applications in many therapies and disease models because they do not operate in clinical "highfrequency" ranges above 50 Hz. Here we show that magnetoelectric materials -applied in bioelectronic devices -enable miniature magnetically-powered neural stimulators that can operate up to clinically-relevant high-frequencies.As an example, we show that ME neural stimulators can effectively treat the symptoms of a hemi-Parkinson's disease model in freely behaving rodents. We further demonstrate that ME-powered devices can be miniaturized to mmsized devices, fully implanted, and wirelessly powered in freely behaving rodents. These results suggest that ME materials are an excellent candidate for wireless power delivery that will enable miniature bioelectronics for both clinical and research applications.

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“…From a high-level system design approach, it is important to recognize that implants for small animals do not need to last for decades, so a semi-hermetic approach using polymers may meet experimental requirements (Boeser et al, 2016 ). Additive manufacturing processes for polymers, such as 3D printing, are recently becoming widely available and have been used to successfully package implantable devices (Kölbl et al, 2014 ; Yu et al, 2020 ). If shown to be viable over appropriate time durations, these approaches may help to significantly ease implantable package design.…”

Section: Technical Challengesmentioning

confidence: 99%

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Datta-Chaudhuri

2021

Bioelectron Med

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Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of tools for chronic stimulation and sensing. A wireless neuromodulation platform small enough for implantation in mice will significantly increase the utility of mouse models in bioelectronic medicine. This perspective examines the necessary functionality of such a system and the technical challenges needed to be overcome for its development. Recent progress is examined and the outlook for the future of implantable devices for mice is discussed.

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34.3 An 8.2mm³ Implantable Neurostimulator with Magnetoelectric Power and Data Transfer

Cited by 26 publications

References 7 publications

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

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34.3 An 8.2mm3 Implantable Neurostimulator with Magnetoelectric Power and Data Transfer

Cited by 26 publications

References 7 publications

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Wireless endovascular nerve stimulation with a millimeter-sized magnetoelectric implant

Magnetoelectric materials for miniature, wireless neural stimulation at therapeutic frequencies

Closed-loop neuromodulation will increase the utility of mouse models in Bioelectronic Medicine

Contact Info

Product

Resources

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34.3 An 8.2mm³ Implantable Neurostimulator with Magnetoelectric Power and Data Transfer