Non-steroidal treatment of cardiac sarcoidosis: A systematic review

Gallegos, Cesia; Oikonomou, Evangelos; Grimshaw, Alyssa; Gulati, Mridu; Young, Bryan D.; Miller, Edward J.

doi:10.1016/j.ijcha.2021.100782

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…Corticosteroids are used as the first-line therapy of CS and may halt the progression of the disease [17]. Steroid-sparing immunosuppressive agents, including methotrexate, cyclophosphamide, azathioprine, rituximab, and tumor necrosis factor (TNF) inhibitors, are used as second-third-line therapy or with steroids [18]. The duration of treatment is dependent on the response to the initial therapy.…”

Section: Table 2: Clinical Manifestations and Prevalence Of Cardiac S...mentioning

confidence: 99%

Heartbeats in Distress: Unveiling Cardiac Sarcoidosis Through Palpitations

Tobun,

Udongwo,

Stephens

et al. 2024

Cureus

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Cardiac sarcoidosis (CS), a rare complication of systemic sarcoidosis, can have subtle or no symptoms. It is characterized by granuloma formation in the myocardium, which can occur in isolation or alongside systemic sarcoidosis. Clinical manifestations include conduction system disorders (e.g., atrioventricular block and ventricular tachyarrhythmia), heart failure, and sudden cardiac death. Timely evaluation and screening for CS are crucial, especially in systemic sarcoidosis patients with limited symptoms. We present the case of a 50-year-old African-American male diagnosed with cardiac sarcoidosis following a recent diagnosis of pulmonary sarcoidosis after experiencing tachycardia for two years, as confirmed by imaging studies.

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Section: Table 2: Clinical Manifestations and Prevalence Of Cardiac S...mentioning

confidence: 99%

Heartbeats in Distress: Unveiling Cardiac Sarcoidosis Through Palpitations

Tobun,

Udongwo,

Stephens

et al. 2024

Cureus

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show abstract

“…Alternatives would have included cyclosporine, azathioprine, and tumour necrosis factor-inhibitors such as infliximab and adalimumab. 24 These corticosteroidsparing agents would provide an alternative to avoiding the multitude of side effects associated with chronic steroid use.…”

Section: Major Criteria For Diagnosing Cardiac Involvement In Sarcoid...mentioning

confidence: 99%

Cardiac sarcoidosis: Difficulties in diagnosis and treatment

Wong

Lim

et al. 2022

Ann Acad Med Singap

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“…While two randomized controlled trials are assessing the efficacy and safety of methylprednisolone (MYocarditis THerapy with Steroids [MYTHS], NCT05150704) and the anti-interleukin-1 drug anakinra (Anakinra Versus Placebo for the Treatment of Acute MyocarditIS [ARAMIS], NCT03018834) in patients with acute myocarditis, the role of immunosuppression is consolidated in eosinophilic, giant cell and sarcoidotic myocarditis [12] , [13] . An updated review in this Journal dealing with the current therapeutic options for cardiac sarcoidosis [14] showed that even if steroids remain the first-line treatment, the use of non-steroidal disease-modifying antirheumatic agents like methotrexate and infliximab is increasing, allowing a reduction in the maintenance steroid dose.…”

Section: Myocarditismentioning

confidence: 99%