Aging and the nervous system

Mather, Mara

doi:10.1016/j.semcdb.2021.05.012

Cited by 1 publication

(2 citation statements)

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“…At the same time, given the inhibitory synapses also present in the vagus-LC pathways (Fornai et al, 2011), resonance frequency breathing may lead inhibitory signals to alternate with the excitatory signals. This strong oscillating vagus nerve signal could help regulate the aging LC, promoting a beneficial phasic burst activity pattern (Omoluabi et al, 2021), in contrast with the high tonic levels of noradrenergic activity that increasingly appear to be the default as people age (see Mather, 2021 and next section).…”

Section: Introductionmentioning

confidence: 99%

“…In humans, cerebrospinal noradrenaline and its metabolites increase with age and Alzheimer’s disease (for reviews see Mather, 2021; Weinshenker, 2018). Salivary alpha amylase provides a non-invasive proxy measure of central norepinephrine activity (Warren et al, 2017) and salivary alpha amylase levels also are greater in older than younger adults (Almela et al, 2011; Birditt et al, 2018; Nater et al, 2013; Strahler et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults

Yoo

Nashiro

Dutt

et al. 2023

Preprint

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Using data from a clinical trial, we tested the hypothesis that daily sessions modulating heart rate oscillations affect older adults’ volume of a region-of-interest (ROI) comprised of adjacent hippocampal subregions with relatively strong locus coeruleus (LC) noradrenergic input. Younger (N=106) and older adults (N=56) completed five weeks of heart rate variability biofeedback. Participants were randomly assigned to one of two daily biofeedback practices: 1) engage in slow-paced breathing (around 10-s per breath or 0.10 Hz) while receiving biofeedback to increase their heart rate oscillations (Osc+); 2) engage in self-selected strategies while receiving biofeedback to decrease their heart rate oscillations (Osc−). Biofeedback did not significantly affect younger adults’ hippocampal volume. Among older adults, the two biofeedback conditions affected volume in the LC-targeted hippocampal ROI differentially with the Osc+ condition showing relatively increased volume and Osc− showing relatively decreased volume. Older adults with greater average spectral power of heart rate at around 0.10 Hz during biofeedback sessions showed greater increases in volume across these regions.

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Section: Introductionmentioning

confidence: 99%