10 K: a large‐scale prospective longitudinal study in Israel

Shilo, Smadar; Bar, Noam; Keshet, Ayya; Talmor‐Barkan, Yeela; Rossman, Hagai; Godneva, Anastasia; Aviv, Yaron; Edlitz, Yochai; Reicher, Lee; Kolobkov, Dmitry; Wolf, Bat Chen; Lotan-Pompan, Maya; Levi, Kohava; Cohen, Ori; Saranga, Hila; Weinberger, Adina; Segal, Eran

doi:10.1007/s10654-021-00753-5

Cited by 15 publications

(9 citation statements)

References 18 publications

(12 reference statements)

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“…Interestingly enough, a subanalysis that we conducted at a greater, food-level resolution, also indicated a partial mediatory role for the latter three species in the effect of ‘wholemeal bread’ and ‘almonds’ consumption on the clinical outcome of ‘time>140’ (online supplemental figure S3 and online supplemental table 8). Importantly, two of these species were also found to be similarly associated with clinical markers and dietary consumption in an independent and larger cohort from an ongoing observational study conducted in our lab (n=7000; the ‘10K’ cohort) 42. Specifically, the two bacterial species UBA11774 sp003507655 (from Lachnospiraceae family) and UBA11471 sp000434215 (from Bacteroidales order) were reported here to partially mediate the association between PPT-adherence and clinical improvements in triglycerides and HbA1c, respectively.…”

Section: Discussionsupporting

confidence: 58%

“…Importantly, urolithin production was negatively associated with serum hs-CRP, triglycerides, body fat mass, body weight, BMI and urinary carnitine in that study, suggesting overall a beneficial role for that bacterial species in weight loss. To further validate the link between ‘ KLE1615 Unknown ’ species (from the Lachnospiraceae family) and diet or metabolic measures, we tested for associations of this species with clinical markers and dietary data in another independent and larger cohort (n=7000) of healthy adults, from an ongoing observational study conducted in our lab (the ‘10K’ cohort) 42. Interestingly, we found that this species was negatively associated with several metabolic markers, including BMI (R=−0.08, p=6.4×10 −11 ), weight (R=−0.1, p=8.2×10 −17 ), hips (R=−0.07, p=2.2×10 −9 ), waist (r=−0.1, p=8×10 −20 ), triglycerides (R=−0.08, p=4.8×10 −11 ), and positively associated with HDL-C (R=0.08, p=7.4×10 −11 ), vitamin B 12 status (R=0.05, p=2.8×10 −4 ) and with dietary consumption of brazil nuts (R=0.04, p=5×10 −4 ), pinenuts (R=0.04, p=1.2×10 −3 ) and walnuts (R=0.05, p=1.8×10 −5 ) (data not shown).…”

Section: Resultsmentioning

confidence: 99%

“…Importantly, two of these species were also found to be similarly associated with clinical markers and dietary consumption in an independent and larger cohort from an ongoing observational study conducted in our lab (n=7000; the '10K' cohort). 42…”

Section: Discussionmentioning

confidence: 99%

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Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes

Ben-Yacov

Godneva

Rein

et al. 2023

Gut

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ObjectiveTo explore the interplay between dietary modifications, microbiome composition and host metabolic responses in a dietary intervention setting of a personalised postprandial-targeting (PPT) diet versus a Mediterranean (MED) diet in pre-diabetes.DesignIn a 6-month dietary intervention, adults with pre-diabetes were randomly assigned to follow an MED or PPT diet (based on a machine-learning algorithm for predicting postprandial glucose responses). Data collected at baseline and 6 months from 200 participants who completed the intervention included: dietary data from self-recorded logging using a smartphone application, gut microbiome data from shotgun metagenomics sequencing of faecal samples, and clinical data from continuous glucose monitoring, blood biomarkers and anthropometrics.ResultsPPT diet induced more prominent changes to the gut microbiome composition, compared with MED diet, consistent with overall greater dietary modifications observed. Particularly, microbiome alpha-diversity increased significantly in PPT (p=0.007) but not in MED arm (p=0.18). Post hoc analysis of changes in multiple dietary features, including food-categories, nutrients and PPT-adherence score across the cohort, demonstrated significant associations between specific dietary changes and species-level changes in microbiome composition. Furthermore, using causal mediation analysis we detect nine microbial species that partially mediate the association between specific dietary changes and clinical outcomes, including three species (fromBacteroidales,Lachnospiraceae,Oscillospiralesorders) that mediate the association between PPT-adherence score and clinical outcomes of hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL-C) and triglycerides. Finally, using machine-learning models trained on dietary changes and baseline clinical data, we predict personalised metabolic responses to dietary modifications and assess features importance for clinical improvement in cardiometabolic markers of blood lipids, glycaemic control and body weight.ConclusionsOur findings support the role of gut microbiome in modulating the effects of dietary modifications on cardiometabolic outcomes, and advance the concept of precision nutrition strategies for reducing comorbidities in pre-diabetes.Trial registration numberNCT03222791.

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Section: Discussionsupporting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

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Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes

Ben-Yacov

Godneva

Rein

et al. 2023

Gut

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“…In addition, the group independently appraised two important MOH reports. On 8/10/2020 a serologic study of Israelis undergoing laboratory testing in the health maintenance organizations was released [ 35 , 36 ], reporting a 7% seroprevalence of IgG antibodies to SARS-CoV2 among children aged 7–19, compared to 3.8% overall. MACC’s critique noted that children had been under-sampled, along with critical population subgroups and geographic regions.…”

Section: Main Textmentioning

confidence: 99%

Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy

Paltiel

Hochner

Chinitz

et al. 2021

Isr J Health Policy Res

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Among the challenges presented by the SARS-CoV2 pandemic are those related to balancing societal priorities with averting threats to population health. In this exceptional context a group of Israeli physicians and public health scholars (multidisciplinary academic group on children and coronavirus [MACC]) coalesced, examining the role of children in viral transmission and assessing the necessity and consequences of restricted in-class education. Combining critical appraisal and analytical skills with public health experience, MACC advocated for safe and monitored school re-opening, stressing the importance of education as a determinant of health, continuously weighing this stance against evolving COVID-19-risk data. MACC’s activities included offering research-based advice to government agencies including Ministries of Health, Finance, and Education. In a setting where government bodies were faced with providing practical solutions to both decreasing disease transmission and maintaining society’s vital activities, and various advisors presented decision-makers with disparate views, MACC contributed epidemiological, clinical and health policy expertise to the debate regarding school closure as a pandemic control measure, and adaptations required for safe re-opening. In this paper, we describe the evolution, activities, policy inputs and media profile of MACC, and discuss the role of academics in advocacy and activism in the midst of an unprecedented public health crisis. A general lesson learned is that academics, based on the rigor of their scientific work and their perceived objectivity, can and should be mobilized to pursue and promote policies based on shared societal values as well as empiric data, even when considerable uncertainty exists about the appropriate course of action. Mechanisms should be in place to open channels to multidisciplinary academic groups and bring their input to bear on decision-making.

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“…In light of the above limitations, the advantages of using fundus imaging at scale for monitoring and identifying systemic health conditions are clear. Accordingly, our study aimed to characterize fundus images that were collected on thousands of healthy individuals as part of the 10K cohort 10 collected in Israel during 2019-2023. We quantify a total of 12 distinct vessels measures, including tortuosity density, vessel density, average width, fractal dimension, distance tortuosity, and curvature tortuosity, calculated separately for arteries and veins, using the automated tool AutoMorph 11 .…”

Section: Introductionmentioning

confidence: 99%

Unveiling Associations Between Retinal Microvascular Architecture and Phenotypes Across Thousands of Healthy Subjects

Shapira,

Shilo,

Talmor-Barkan

et al. 2024

Preprint

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Fundus imaging has emerged as a powerful tool, allowing for high-resolution and non-invasive visualization of the fundus microvasculature. Recent advancements in artificial intelligence (AI) have enabled the quantification of fundus microvascular characteristics, paving the way for the development of predictive markers for systemic conditions. In this study, we characterize the fundus microvasculature among 8467 healthy individuals, aged 40-70 years. We employ a fully automated segmentation tool to calculate 12 distinct vessel measures, including tortuosity density, vessel density, average width, fractal dimension, distance tortuosity, and curvature tortuosity for both arteries and veins. We provide reference values for these measures by age and sex, and explore the associations between these fundus vessel measures and various clinical features. Our analysis revealed numerous significant correlations, including connections between fundus arterial measures and cardiovascular measurements, lipid profile, sleep apnea indices, glycemic profile, body composition, and smoking status. This comprehensive analysis of fundus microvasculature anatomy in a large healthy population contributes to the growing field of oculomics and highlights the potential of fundus imaging for earlier detection and monitoring of systemic diseases such as metabolic syndrome, cardiovascular diseases and sleep disorders.

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10 K: a large‐scale prospective longitudinal study in Israel

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 15 publications

References 18 publications

Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes

Gut microbiome modulates the effects of a personalised postprandial-targeting (PPT) diet on cardiometabolic markers: a diet intervention in pre-diabetes

Academic activism on behalf of children during the COVID-19 pandemic in Israel; beyond public health advocacy

Unveiling Associations Between Retinal Microvascular Architecture and Phenotypes Across Thousands of Healthy Subjects

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