Inhaled levosimendan: New opportunities with an old drug

Evans, Michael A.; Suresh, Santhanam

doi:10.1016/j.jclinane.2021.110337

Cited by 1 publication

(1 citation statement)

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“…Investigations into bioavailability within the pulmonary vasculature and systemic circulation, coupled with thorough safety evaluations in various patient populations, are crucial to determining the viability of inhaled levosimendan in numerous treating conditions that require targeted pulmonary vasodilation. Although studies investigating the significance of inhaled levosimendan are still in early phases, preliminary data suggests that it can be applied in targeted pulmonary vasodilation, particularly in the context of pulmonary hypertension [34]. Thus, largescale, randomized clinical trials are needed to determine the safety, efficacy, and optimal dosing protocol of inhaled levosimendan in various pulmonary conditions.…”

Section: Inhaled Levosimendanmentioning

confidence: 99%

Breaking Boundaries: Novel Effects of Levosimendan in Various Diseases

Zhang,

Zhao,

Liu

2024

IJDDP

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Review Breaking Boundaries: Novel Effects of Levosimendan in Various Diseases Hongyuan Zhang 1, Minxing Zhao 2, and Yanrong Liu 1,3,* 1 Michael Smith building, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, M139PT Manchester, UK. 2 Loreto High School, Chorlt on, M217SW Manchester, UK. 3 The Department of Cardiology, the 1st Affiliated Nanjing Medical University, 300 Guangzhou Road, Nanjing, China. * Correspondence: yanrong.liu@manchester.ac.uk Received: 6 February 2024 Accepted: 23 February 2024 Published: 18 March 2024 Abstract: Levosimendan, an inodilator that has been applied in clinical use for over two decades, has transcended its initial indication in the management of acutely decompensated chronic heart failure. Over the years, it has been adopted in septic shock, perioperative use of cardiac surgery, advanced end-stage heart failure, and has shown potential for inhaled administration, highlighting its versatility. Levosimendan has diverse mechanisms of action which mediate its non-traditional uses. Ongoing research aims to expand our understanding and develop personalized treatment strategies for the use of levosimendan. The significance of levosimendan in acute decompensated heart failure and cardiogenic shock, highlights its evolving role in contemporary cardiovascular medicine. This comprehensive review explores its pharmacodynamics, effects, and the challenges and opportunities it presents in various clinical settings. We describe levosimedan’s expanding usage, ranging from septic shock, intermittent intravenous in advanced heart failure, perioperative cardiac surgery and pulmonary hypertension management by inhaled levosimendan as well as its future prospects.

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Section: Inhaled Levosimendanmentioning

confidence: 99%