Thyrotoxic Periodic Paralysis

Fralick, Michael; Sarma, Shohinee

doi:10.1056/nejmicm2030770

Cited by 3 publications

(4 citation statements)

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“…La sospecha inicial es clínica y se basa en las características epidemiológicas del paciente, los antecedentes endocrinológicos tiroideos y la presentación aguda de la parálisis muscular. En la figura 2 se describen las claves clínicas que con frecuencia presentan los pacientes con PHPT 10,13,14 .…”

Section: Discussionunclassified

“…• Hombre joven • Presentación esporádica • Presentación recurrente • Precipitada por ingesta copiosa de hidratos de carbono, comida salada o alcohol • Precipitada por esfuerzo físico extenuante • Antecedente familiar de hipertiroidismo • Mayor compromiso de las extremidades que del tronco • Signos y síntomas de hipertiroidismo • Hipopotasemia y perfil tiroideo compatible con tirotoxicosis • Baja excreción urinaria de potasio • Baja excreción urinaria de fosfatos • Electromiografía con potenciales de acción musculares de baja amplitud Epidemiológicas Clínicas y paraclínicas Figura 2. Características clásicas del paciente con parálisis hipopotasémica periódica secundaria a tirotoxicosis 10,13,14 . Tabla 3.…”

Section: Discussionunclassified

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Manejo exitoso de la parálisis hipopotasémica periódica, una causa grave de debilidad aguda en urgencias. Reporte de caso

Vélez-Leal,

Gómez-Otálvaro,

Cardozo-Ocampo

2024

REIE

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Section: Discussionunclassified

Manejo exitoso de la parálisis hipopotasémica periódica, una causa grave de debilidad aguda en urgencias. Reporte de caso

Vélez-Leal,

Gómez-Otálvaro,

Cardozo-Ocampo

2024

REIE

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“…Cases of PP are either hereditary, like familial hypokalaemic periodic paralysis (FHPP), or acquired, like thyrotoxic periodic paralysis (TPP). TPP is more frequently cited and is associated with hyperthyroidism and thyrotoxicosis 1. If left unrecognised, its mortality rate nears 80% due to cardiac excitation, ventricular arrhythmias and cardiac arrest 2 3.…”

Section: Introductionmentioning

confidence: 99%

Refractory familial hypokalaemic periodic paralysis leading to cardiovascular compromise

et al. 2022

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Familial hypokalaemic periodic paralysis (FHPP) is a rare neuromuscular disorder that is classified under periodic paralysis (PP), which is characterised by episodes of muscle weakness. Common triggers include intense exercise, fasting or consumption of carbohydrate-rich meals. Hypokalaemic PP has an incidence of 1 in 100 000; despite the temporal association, cardiac manifestations are exceedingly rare. We present a case of FHPP, a channelopathy presenting with severe refractory hypokalaemia. The challenges with our patient were maintaining potassium levels within normal ranges and initiating a close follow-up plan. Due to the lack of clinical guidance in our case, many aspects of care, including surveillance, medications and genetic testing, remain unaddressed. Medical management includes aggressive correction with supplements, potassium-sparing diuretics and carbonic anhydrase inhibitors. Severe cases of dysrhythmias, especially ventricular fibrillation, require electrophysiology evaluation and possible implantation of a defibrillator to prevent sudden cardiac death.

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“…Research conducted in 2018 at the Dr. Soetomo Regional General Hospital Surabaya found Graves' disease in as many as 66.7% of all cases of hyperthyroidism [ 2 ]. One of the complications that can occur in patients with Graves' disease is periodic paralytic thyrotoxicosis [ 3 ] (see Fig. 1 , Fig.…”

Section: Introductionmentioning

confidence: 99%

Management of hypokalemia in patients with thyrotoxicosis periodic paralysis in Soetomo general hospital: A case report

Idham

Prajitno

2022

Annals of Medicine &Amp; Surgery

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Thyrotoxic Periodic Paralysis

Cited by 3 publications

References 0 publications

Manejo exitoso de la parálisis hipopotasémica periódica, una causa grave de debilidad aguda en urgencias. Reporte de caso

Manejo exitoso de la parálisis hipopotasémica periódica, una causa grave de debilidad aguda en urgencias. Reporte de caso

Refractory familial hypokalaemic periodic paralysis leading to cardiovascular compromise

Management of hypokalemia in patients with thyrotoxicosis periodic paralysis in Soetomo general hospital: A case report

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