A cortico-collicular pathway for motor planning in a memory-dependent perceptual decision task

Duan, Chunyu A.; Pan, Yuxin; Ma, Guofen; Zhou, Taotao; Zhang, Siyu; Xu, Ning-long

doi:10.1038/s41467-021-22547-9

Cited by 35 publications

(67 citation statements)

References 69 publications

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“…Second, other studies using two-alternative choice tasks have shown larger numbers of neurons with action selection correlates than we observed in frontal, parietal, or sensory association cortex ( Duan et al, 2021 ; Erlich et al, 2011 ; Funahashi et al, 1991 ; Gu et al, 2007 ; Guo et al, 2015 ; Harvey et al, 2012 ; Li et al, 2015 ; Romo and de Lafuente, 2013 ). To the best of our knowledge, all such tasks either used stimuli requiring integrating evidence over time or enforced a delay between stimulus onset and motor action, during which the selectivity for different actions grows steadily over several hundred ms.…”

Section: Discussioncontrasting

confidence: 48%

Sensory coding and the causal impact of mouse cortex in a visual decision

Zatka-Haas

Steinmetz

Carandini

et al. 2021

eLife

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Correlates of sensory stimuli and motor actions are found in multiple cortical areas, but such correlates do not indicate whether these areas are causally relevant to task performance. We trained mice to discriminate visual contrast and report their decision by steering a wheel. Widefield calcium imaging and Neuropixels recordings in cortex revealed stimulus-related activity in visual (VIS) and frontal (MOs) areas, and widespread movement-related activity across the whole dorsal cortex. Optogenetic inactivation biased choices only when targeted at VIS and MOs,proportionally to each site's encoding of the visual stimulus, and at times corresponding to peak stimulus decoding. A neurometric model based on summing and subtracting activity in VIS and MOs successfully described behavioral performance and predicted the effect of optogenetic inactivation. Thus, sensory signals localized in visual and frontal cortex play a causal role in task performance, while widespread dorsal cortical signals correlating with movement reflect processes that do not play a causal role.

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Section: Discussioncontrasting

confidence: 48%

Sensory coding and the causal impact of mouse cortex in a visual decision

Zatka-Haas

Steinmetz

Carandini

et al. 2021

eLife

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“…The role of these inputs would be to override the 'turn towards stimuli' contingency normally represented by turning circuitry in SC, including functionally inhibiting contraversive turnpromoting neurons (c.f. (Huda et al, 2020;Lee and Sabatini, 2020;Duan et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, in head-fixed mice, activation of regions of SC biases eye movements (Zahler et al, 2021) towards the contralateral side. Inhibiting motor-related SC does the opposite, biasing the animal towards ipsilateral movements (Stubblefield, Costabile and Felsen, 2013;Lee and Sabatini, 2020;Duan et al, 2021;Zahler et al, 2021). The reader should note that when head-fixed mice have to rotate a ball or wheel beneath them, most active neurons in motor-related SC prefer ipsilateral turns (Steinmetz et al, 2019) and unilateral inhibition of motor-related SC biases animals away from ipsilateral turns (Huda et al, 2020).…”

Section: Turningmentioning

confidence: 99%

“…SC is primarily concerned with turning towards the contralateral side, but activation of anteriormedial SC can evoke ipsiversive head turns (Isa et al, 2020), and an ipsiversive bias has been reported for some medial SC neurons (cuneiform nucleus-projectors) (Isa et al, 2020) [but not others (primary auditory cortexrecipient) (Zingg et al, 2017)]. Activation of GABAergic SC neurons (VGAT+ and GAD2+ respectively) can also bias the mouse towards ipsiversive turns (Duan et al, 2021;Hao, Thomas and Li, 2021) (but see (Essig, Hunt and Felsen, 2021;Sans-Dublanc et al, 2021).…”

Section: Turningmentioning

confidence: 99%

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Functional Organisation of the Mouse Superior Colliculus

Wheatcroft¹,

Saleem²,

Solomon³

2021

Preprint

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The superior colliculus (SC) is a highly conserved area of the mammalian midbrain that is widely implicated in the organisation and control of behaviour. SC receives input from a large number of brain areas, and provides outputs to a large number of areas. The convergence and divergence of anatomical connections with different areas and systems provides challenges for understanding how SC contributes to behaviours. Recent work in mouse has provided large anatomical datasets, and a wealth of new data from experiments that identify and manipulate different cells within SC, and its inputs and outputs. These data offer an opportunity to better understand the functional roles of SC. However, some of the observations appear, at first sight, to be contradictory. Here we review this recent work and suggest a simple framework which can capture the observations, and that requires only a small change to previous models. Specifically, the functional organisation of SC can be explained by supposing that three largely distinct circuits support three largely distinct classes of behaviour - arrest, turning towards, and the triggering of escape or pursuit. These behavioural classes are supported by the optic, intermediate and deep layers respectively.

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“…Since the Neuropixels probe is highly light-sensitive (Jun et al, 2017), the LED stimulation can cause light artefacts, transient voltage deflections, preferentially at the onset and offset of light pulses. Therefore, the LED onset (−2 to 6ms) and LED offset (−0.6 to 1 ms) were excluded from the data analysis (Bennett et al, 2019; Duan et al, 2021; Sans-Dublanc et al, 2021).…”

Section: Methodsmentioning

confidence: 99%

Tangential high-density electrode insertions allow to simultaneously measure neuronal activity across an extended region of the visual field in mouse superior colliculus

Sibille

Gehr

Teh

et al. 2021

Preprint

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The superior colliculus (SC) is a midbrain structure that plays a central role in visual processing. Although we have learned a considerable amount about the function of single SC neurons, the way in which sensory information is represented and processed on the population level in awake behaving animals and across a large region of the retinotopic map is still largely unknown. Partially because the SC is anatomically located below the cortical sheet and the transverse sinus, it is technically difficult to measure neuronal activity from a large population of neurons in SC. To address this, we propose a tangential recording configuration using high-density electrode probes (Neuropixels) in mouse SC in vivo that permits a large number of recording sites (~200) accessibility inside the SC circuitry. This approach thereby provides a unique opportunity to measure the activity of SC neuronal populations composing up to ~2 mm of SC tissue and characterized by receptive fields covering an extended region in the visual field. Here we describe how to perform tangential recordings along the anterior-posterior and the medio-lateral axis of the mouse SC in vivo and how to combine this approach with optogenetic tools for cell-type identification on the population level.

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A cortico-collicular pathway for motor planning in a memory-dependent perceptual decision task

Cited by 35 publications

References 69 publications

Sensory coding and the causal impact of mouse cortex in a visual decision

Sensory coding and the causal impact of mouse cortex in a visual decision

Functional Organisation of the Mouse Superior Colliculus

Tangential high-density electrode insertions allow to simultaneously measure neuronal activity across an extended region of the visual field in mouse superior colliculus

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