A New Application of MALDI Biotyper for a Potential Use in Therapeutic Drug Monitoring of Voriconazole

Abstract

We present a proof of concept study on the use of MALDI Biotyper to detect and monitor the levels of voriconazole in human serum. A simple extraction-concentration method and a MALDI Biotyper protocol were developed and a parent ion of voriconazole (1 H+) could be detected and quantified with good reproducibility. Our results point to a new application of MALDI Biotyper for therapeutic drug monitoring.