Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses

Kang, Mengmeng; Oderinde, Olayinka; Han, Xuelian; Zhang, Zhihong

doi:10.1016/j.ijbiomac.2021.05.029

Cited by 20 publications

(10 citation statements)

References 82 publications

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“…In oxidized hydroxyethyl cellulose, a hydrogel functionalized allyl spiro-oxazine derivative was applied to endow photo-and pH-sensitive substrates. This hydrogel has a good pH environment adaptability and was found non-toxic in the in vitro test; this oxidized hydroxyethyl cellulose hydrogel had significant use as a safe development, is fashionable, such as for pH-detectable contact lenses [63].…”

Section: Dexamethasonementioning

confidence: 99%

“…Five marketed silicone contact lenses are ACUVUE ADVANCE and ACUVUA OASYS by Johnson and Johnson vision care; O2OPTIX by Alcon, Fort Worth; NIGHT and DAY by Alcon, Fort Worth; and pure vision by Bausch and Lomb, Bridgewater; these were used to increase the release of dexamethasone [62]. Kang et al developed contact lenses of oxidized hydroxyethyl cellulose and an allyl co-polymer-based hydrogel [63].…”

Section: Contact Lensesmentioning

confidence: 99%

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Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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One of the major impediments to drug development is low aqueous solubility and thus poor bioavailability, which leads to insufficient clinical utility. Around 70–80% of drugs in the discovery pipeline are suffering from poor aqueous solubility and poor bioavailability, which is a major challenge when one has to develop an ocular drug delivery system. The outer lipid layer, pre-corneal, dynamic, and static ocular barriers limit drug availability to the targeted ocular tissues. Biopharmaceutical Classification System (BCS) class II drugs with adequate permeability and limited or no aqueous solubility have been extensively studied for various polymer-based solubility enhancement approaches. The hydrophilic nature of cellulosic polymers and their tunable properties make them the polymers of choice in various solubility-enhancement techniques. This review focuses on various cellulose derivatives, specifically, their role, current status and novel modified cellulosic polymers for enhancing the bioavailability of BCS class II drugs in ocular drug delivery systems.

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Section: Dexamethasonementioning

confidence: 99%

Section: Contact Lensesmentioning

confidence: 99%

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

et al. 2021

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“…comprise abundant hydroxyl groups in their chemical structure, which can be easily transformed into dialdehyde functional groups by a simple oxidation process using appropriate oxidizing agents such as sodium or potassium periodate. The oxidation of dextran is among the most widely studied processes ( Figure 1 a), while a similar synthetic procedure has been employed in the oxidation of other natural polymers; for example, sodium alginate, hyaluronic acid, and starch [ 19 , 20 , 21 ], as well as for hydroxyethyl cellulose [ 22 , 23 ] gellan gum [ 24 , 25 ], and β-cyclodextrin (β-CD) [ 26 , 27 ].…”

Section: Chemical Functionalization Of Polysaccharidesmentioning

confidence: 99%

Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

et al. 2023

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There is a growing concern about wound care, since traditional dressings such as bandages and sutures can no longer meet existing needs. To address the demanding requirements, naturally occurring polymers have been extensively exploited for use in modern wound management. Polysaccharides, being the most abundant biopolymers, have some distinct characteristics, including biocompatibility and biodegradability, which render them ideal candidates for wound healing applications. Combining them with inorganic and organic moieties can produce effective multifunctional composites with the desired mechanical properties, high wound healing efficiencies and excellent antibacterial behavior. Recent research endeavors focus on the development of stimuli-responsive polysaccharide composites for biomedical applications. Polysaccharide composites, being sensitive to the local environment, such as changes of the solution temperature, pH, etc., can sense and react to the wound conditions, thus promoting an effective interaction with the wound. This review highlights the recent advances in stimuli-responsive polysaccharide hydrogels and their composites for use in wound healing applications. The synthetic approaches, physical, chemical, and biochemical properties as well as their function in wound healing will be discussed.

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“…[ 259 ] HEC‐based hydrogels have potential applications in the creation of safe, stylish, intelligent, pH‐detectable, and fashionable contact lenses. [ 260 ] A novel in situ gelling delivery system was developed by combining HEC and gellan gum (GG) with tropicamide and phenylephrine hydrochloride. This formulation shows promise as an alternative to traditional eye drops due to its ability to prolong ocular surface accumulation time by >3 h and improve drug bioavailability.…”

Section: Natural Biomaterials For Corneal Tissue Engineeringmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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Development of oxidized hydroxyethyl cellulose-based hydrogel enabling unique mechanical, transparent and photochromic properties for contact lenses

Cited by 20 publications

References 82 publications

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Cellulosic Polymers for Enhancing Drug Bioavailability in Ocular Drug Delivery Systems

Stimuli-Responsive Polysaccharide Hydrogels and Their Composites for Wound Healing Applications

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

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