An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the “Gold Standard” Bone Graft

Tournier, Pierre; Guicheux, Jérôme; Paré, Arnaud; Véziers, Joëlle; Barbeito, Ana; Bardonnet, Raphaël; Corre, Pierre; Geoffroy, Valérie; Weiss, Pierre; Gaudin, Alexis

doi:10.3389/fbioe.2021.658853

Cited by 6 publications

(4 citation statements)

References 58 publications

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“… 173 Compared to autologous bone grafts, allogeneic bone grafts are rendered nonviable through irradiation or freeze-drying, which reduces their bone inductivity and may ultimately lead to graft failure. 174 , 175 While cellular bone matrices have been recently developed to enhance the bioactivity of grafts, they carry an increased risk of immune rejection and do not guarantee cell viability during preservation and implantation. 175 At the same time, allogeneic transplantation carries inherent risks related to disease transmission, reduced structural integrity, and higher costs.…”

Section: Neuro-bone Tissue Engineeringmentioning

confidence: 99%

Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

Sun,

Ye,

Chen

et al. 2023

Bone Res

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The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve endings release neurogenic factors and sense skeletal signals, which mediate bone metabolism and skeletal pain. In recent years, bone tissue engineering has increasingly focused on the effects of the nervous system on bone regeneration. Simultaneous regeneration of bone and nerves through the use of materials or by the enhancement of endogenous neurogenic repair signals has been proven to promote functional bone regeneration. Additionally, emerging information on the mechanisms of skeletal interoception and the central nervous system regulation of bone homeostasis provide an opportunity for advancing biomaterials. However, comprehensive reviews of this topic are lacking. Therefore, this review provides an overview of the relationship between nerves and bone regeneration, focusing on tissue engineering applications. We discuss novel regulatory mechanisms and explore innovative approaches based on nerve–bone interactions for bone regeneration. Finally, the challenges and future prospects of this field are briefly discussed.

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Section: Neuro-bone Tissue Engineeringmentioning

confidence: 99%

Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

Sun,

Ye,

Chen

et al. 2023

Bone Res

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“…For the repair of bone defects, autologous and allogeneic bone transplantation is still the “gold standard” [1]. However, bone transplantation such as infection, disease transmission, insufficient sources, and immune rejection [2].…”

Section: Introductionmentioning

confidence: 99%

Biofunctionalisation strategies of material surface and the inspired biological effects for bone repair

Duan,

Chang,

Zhang

et al. 2024

Biosurface and Biotribology

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Due to trauma and disease, bone defects endanger the healthy life of human beings. At present, the gold standard for bone defect repair is still autologous bone transplantation and allogeneic bone transplantation. However, its insufficient source, potential disease transmission and immune rejection limit its clinical application. Therefore, the development of bone repair materials plays an important role in promoting bone repair. As the interface between material and tissue, the surface of the material plays an important role in the reaction after implantation, which determines the effectiveness of defect repair treatment. With the development of surface engineering and technology, bone repair materials have developed from biological inertia to biological activity by endowing various biological functions by controlling the composition, topological morphology and structure of the material surface etc. The inspired biofunctionalisation of material surface includes the capacities of inducing osteogenesis, promoting angiogenesis, antibacterial, immune regulation etc., as well as integration of postoperative repair and treatment. The authors review the biofunctionalisation of biomaterial surface and the inspired biological effects for bone repair, mainly including physical and chemical properties of material surface to regulate osteogenesis, and functional strategy of bone repair material surface.

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“…Allogeneic grafts are available as fresh, frozen, or lyophilized (frozen and dried; mineralized [inorganic bone matrix] or demineralized [organic bone matrix]), available in blocks or particles [9]. The bone to be used is available fresh (without processing), fresh-frozen (fresh-frozen, FFBA), or lyophilized (freezedry).…”

Section: Introductionmentioning

confidence: 99%

Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft: A Feasible Option for Maxillary Bone Reconstruction

Motta,

Soares,

Fernandes

et al. 2024

JRM

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Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ridges. Thus, the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB (lyophilized) graft and verify its reliability. Eight individuals were included from 2014 to 2018. The first surgery was performed to install homologous bone blocks in the maxilla. The period of the second intervention varied between 5 months and 15 days to 11 months (≈7.93 months). The biopsies were taken from the central region of the matured graft during the surgery for implant placement. All patients presented clinical and radiographic conditions for the installation of dental implants. There was a 100% of survival rate. The histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial, with connective tissue present, and newly formed bone juxtaposed on its surface. There were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process; the remodeling process can be found through the reverse lines. A limited focus of necrosis with fibrosis was detected, with small resorption and areas of inflammatory infiltrate, but without clinical significance. The homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft (gold standard), with predictable clinical and favorable histological results. The patients had a shorter surgical period, low morbidity, and an unlimited amount of biomaterial available at an accessible cost.

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An Extrudable Partially Demineralized Allogeneic Bone Paste Exhibits a Similar Bone Healing Capacity as the “Gold Standard” Bone Graft

Cited by 6 publications

References 58 publications

Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges

Biofunctionalisation strategies of material surface and the inspired biological effects for bone repair

Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft: A Feasible Option for Maxillary Bone Reconstruction

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