Lower Extremity Arterial Disease as a Predictor of Incident Atrial Fibrillation and Cardiovascular Events

Tseng, Andrew; Girardo, Marlene; Firth, Christine; Bhatt, Shubhang K.; Liedl, David; Wennberg, Paul W.; Shen, Win‐Kuang; Cooper, Leslie T.; Shamoun, Fadi

doi:10.1016/j.mayocp.2020.07.036

Cited by 3 publications

(1 citation statement)

References 22 publications

(23 reference statements)

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“…Chronic kidney disease (CKD) is a major global health burden, affecting up to 15% of adults [1], with an increase in stage 1 CKD of 15% being observed in the last decade [1]. The most common comorbidities in CKD patients include diabetes mellitus, arterial hypertension, coronary artery disease, peripheral artery disease, anemia, and obesity, which are known mortality risk factors in the general population [1][2][3][4][5][6]. The risk of death in the end-stage renal disease (ESRD) population is four times higher compared to the age and sex-adjusted general population.…”

Section: Introductionmentioning

confidence: 99%

Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients—A Genetic Cohort Study

Świderska

Mostowska

Skrypnik

et al. 2022

JCM

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Background: Patients undergoing hemodialysis (HD) therapy have an increased risk of death compared to the general population. We investigated whether selected single nucleotide variants (SNVs) involved in glucose and lipid metabolism are associated with mortality risk in HD patients. Methods: The study included 805 HD patients tested for 11 SNVs in FOXO3, IGFBP3, FABP1, PCSK9, ANGPTL6, and DOCK6 using HRM analysis and TaqMan assays. FOXO3, IGFBP3, L-FABP, PCSK9, ANGPTL6, and ANGPTL8 plasma concentrations were measured by ELISA in 86 individuals. The Kaplan–Meier method and Cox proportional hazards models were used for survival analyses. Results: We found out that the carriers of a C allele in ANGPTL6 rs8112063 had an increased risk of all-cause, cardiovascular, and cardiac mortality. In addition, the C allele of DOCK6 rs737337 was associated with all-cause and cardiac mortality. The G allele of DOCK6 rs17699089 was correlated with the mortality risk of patients initiating HD therapy. The T allele of FOXO3 rs4946936 was negatively associated with cardiac and cardiovascular mortality in HD patients. We observed no association between the tested proteins’ circulating levels and the survival of HD patients. Conclusions: The ANGPTL6 rs8112063, FOXO3 rs4946936, DOCK6 rs737337, and rs17699089 nucleotide variants are predictors of survival in patients undergoing HD.

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Section: Introductionmentioning

confidence: 99%

Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients—A Genetic Cohort Study

Świderska

Mostowska

Skrypnik

et al. 2022

JCM

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Peripheral Arterial Disease, Stroke, and Mortality in Patients with Atrial Fibrillation

Kawada

2022

The American Journal of Medicine

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Primary aldosteronism and lower-extremity arterial disease: a two-sample Mendelian randomization study

Hu,

Zeng,

Chen

et al. 2023

Cardiovasc Diabetol

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Background and Aims Primary aldosteronism (PA) is an adrenal disorder of autonomous aldosterone secretion which promotes arterial injury. We aimed to explore whether PA is causally associated with lower-extremity arterial disease (LEAD). Methods We included 39,713 patients with diabetes and 419,312 participants without diabetes from UK Biobank. We derived a polygenic risk score (PRS) for PA based on previous genome-wide association studies (GWAS). Outcomes included LEAD and LEAD related gangrene or amputation. We conducted a two-sample Mendelian randomization analysis for PA and outcomes to explore their potential causal relationship. Results In whole population, individuals with a higher PA PRS had an increased risk of LEAD. Among patients with diabetes, compared to the subjects in the first tertile of PA PRS, subjects in the third tertile showed a 1.24-fold higher risk of LEAD (OR 1.24, 95% CI 1.03–1.49) and a 2.09-fold higher risk of gangrene (OR 2.09, 95% CI 1.27–3.44), and 1.72-fold higher risk of amputation (OR 1.72, 95% CI 1.10–2.67). Among subjects without diabetes, there was no significant association between PA PRS and LEAD, gangrene or amputation. Two-sample Mendelian randomization analysis indicated that genetically predictors of PA was significantly associated with higher risks of LEAD and gangrene (inverse variance weighted OR 1.20 [95% CI 1.08–1.34]) for LEAD, 1.48 [95% CI 1.28–1.70] for gangrene), with no evidence of significant heterogeneity or directional pleiotropy. Conclusions Primary aldosteronism is genetically and causally associated with higher risks of LEAD and gangrene, especially among patients with diabetes. Targeting on the autonomous aldosterone secretion may prevent LEAD progression.

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Lower Extremity Arterial Disease as a Predictor of Incident Atrial Fibrillation and Cardiovascular Events

Cited by 3 publications

References 22 publications

Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients—A Genetic Cohort Study

Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients—A Genetic Cohort Study

Peripheral Arterial Disease, Stroke, and Mortality in Patients with Atrial Fibrillation

Primary aldosteronism and lower-extremity arterial disease: a two-sample Mendelian randomization study

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