“…They originate from epithelial cells of the aerodigestive tract [ 2 , 3 , 4 ] and may be classified according to their localization: nasopharyngeal, tongue, oral, and laryngeal squamous cell carcinoma (NSCC, TSCC, OSCC, and LSCC, respectively) [ 2 , 3 , 5 , 6 ]. The most common risk factors are alcohol consumption, tobacco smoking, and human papilloma virus (HPV) infection [ 7 , 8 ]. Interestingly, among younger patients, HPV infection is the most important risk factor, often associated with better treatment outcomes and recovery [ 1 , 2 , 3 , 4 , 6 , 9 , 10 ].…”