Probing the mineralized tissue-adhesive interface for tensile nature and bond strength

Sarikaya, Rizacan; Ye, Qiang; Song, Linyong; Tamerler, Candan; Spencer, Paulette; Misra, Anil

doi:10.1016/j.jmbbm.2021.104563

Cited by 7 publications

(2 citation statements)

References 65 publications

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“…The mechanical strength for pristine polymer discs (n = 8 for each polymer type) and disc (n = 6 for each polymer type) incubated with S. mutans was measured by testing the Diametral tensile strength (DTS-kg Â f/cm 2 ) using the 858 Mini Bionix ® II, MTS, Eden Prairie system by applying a load up to 5.0 kN. The DTS values were calculated using the average discs diameter and thickness for EGDMA (4.96 mm ± 0.0655 mm and 2.51 mm ± 0.2385 mm) and EGEMA polymer discs (5.01 mm ± 0.1862 mm and 2.63 mm ± 0.2109 mm) in the previously published equation [35][36][37] :…”

Section: Diametral Tensile Strength and Total Energy To Fracturementioning

confidence: 99%

A novel methacrylate derivative polymer that resists bacterial cell‐mediated biodegradation

et al. 2021

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This study tests biodegradation resistance of a custom synthesized novel ethylene glycol ethyl methacrylate (EGEMA) with ester bond linkages that are external to the central polymer backbone when polymerized. Ethylene glycol dimethacrylate (EGDMA) with internal ester bond linkages and EGEMA discs were prepared in a polytetrafluoroethylene (PTFE) mold using 40 μl macromer and photo/co‐initiator mixture cured for 40 s at 1000 mW/cm2. The discs were stored in the constant presence of Streptococcus mutans (S. mutans) in Todd Hewitt Yeast + Glucose (THYE+G) media up to 9 weeks (n = 8 for each macromer type) and physical/mechanical properties were assessed. Initial measurements EGEMA versus EGDMA polymer discs showed equivalent degree of conversion (45.69% ± 2.38 vs. 46.79% ± 4.64), diametral tensile stress (DTS; 8.12± 2.92 MPa vs. 6.02 ± 1.48 MPa), and low subsurface optical defects (0.41% ± 0.254% vs. 0.11% ± 0.074%). The initial surface wettability (contact angle) was slightly higher (p ≤ .012) for EGEMA (62.02° ± 3.56) than EGDMA (53.86° ± 5.61°). EGDMA showed higher initial Vicker's hardness than EGEMA (8.03 ± 0.88 HV vs. 5.93 ± 0.69 HV; p ≤ .001). After 9 weeks of S. mutans exposure, EGEMA (ΔDTS—1.30 MPa) showed higher resistance to biodegradation effects with a superior DTS than EGDMA (ΔDTS—6.39 MPa) (p = .0039). Visible and scanning electron microscopy images of EGEMA show less surface cracking and defects than EGDMA. EGDMA had higher loss of material (18.9% vs. 8.5%, p = .0009), relative changes to fracture toughness (92.5% vs. 49.2%, p = .0022) and increased water sorption (6.1% vs. 1.9%, p = .0022) compared to EGEMA discs. The flipped external ester group linkage design is attributed to EGEMA showing higher resistance to bacterial degradation effects than an internal ester group linkage design methacrylate.

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Section: Diametral Tensile Strength and Total Energy To Fracturementioning

confidence: 99%

A novel methacrylate derivative polymer that resists bacterial cell‐mediated biodegradation

et al. 2021

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“…The retention of composite resins relies on the adhesive system, which infiltrates into the collagen matrix to adhere to dentin [ 1 , 8 , 9 , 10 , 11 ]. Adhesion and adhesive performance on dentin are especially challenging due to the complexity of dentin, a mineralized dynamic biological composite tissue composed of 70% hydroxyapatite (HA), 30% type I collagen, multiple non-collagenous proteins, and water [ 12 , 13 , 14 ]. Due to the multi-scaled and multi-faceted events taking place at this complex resin–dentin adhesive interface, strategies developed so far have been slow to address the short lifespan of resin–dentin bonding and subsequently prevent the repeated failure of composite resin restorations [ 3 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization

Cloyd

Boone

et al. 2023

IJMS

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Overcoming the short lifespan of current dental adhesives remains a significant clinical need. Adhesives rely on formation of the hybrid layer to adhere to dentin and penetrate within collagen fibrils. However, the ability of adhesives to achieve complete enclosure of demineralized collagen fibrils is recognized as currently unattainable. We developed a peptide-based approach enabling collagen intrafibrillar mineralization and tested our hypothesis on a type-I collagen-based platform. Peptide design incorporated collagen-binding and remineralization-mediating properties using the domain structure conservation approach. The structural changes from representative members of different peptide clusters were generated for each functional domain. Common signatures associated with secondary structure features and the related changes in the functional domain were investigated by attenuated total reflectance Fourier-transform infrared (ATR-FTIR) and circular dichroism (CD) spectroscopy, respectively. Assembly and remineralization properties of the peptides on the collagen platforms were studied using atomic force microscopy (AFM). Mechanical properties of the collagen fibrils remineralized by the peptide assemblies was studied using PeakForce-Quantitative Nanomechanics (PF-QNM)-AFM. The engineered peptide was demonstrated to offer a promising route for collagen intrafibrillar remineralization. This approach offers a collagen platform to develop multifunctional strategies that combine different bioactive peptides, polymerizable peptide monomers, and adhesive formulations as steps towards improving the long-term prospects of composite resins.

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Antibacterial effect, cytotoxicity, and bond strength of a modified dental adhesive containing silver nanoparticles

et al. 2022

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Probing the mineralized tissue-adhesive interface for tensile nature and bond strength

Cited by 7 publications

References 65 publications

A novel methacrylate derivative polymer that resists bacterial cell‐mediated biodegradation

A novel methacrylate derivative polymer that resists bacterial cell‐mediated biodegradation

Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization

Antibacterial effect, cytotoxicity, and bond strength of a modified dental adhesive containing silver nanoparticles

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