Interaction between cocaine use and sleep behavior: A comprehensive review of cocaine's disrupting influence on sleep behavior and sleep disruptions influence on reward seeking

Bjorness, Theresa E.; Greene, Robert

doi:10.1016/j.pbb.2021.173194

Cited by 17 publications

(17 citation statements)

References 166 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cocaine also reduces sleep in Drosophila (Lebestky et al, 2009), as it does in mammals (Bjorness and Greene, 2021). Therefore, Drosophila show face-valid responses to cocaine.…”

Section: Introductionmentioning

confidence: 88%

“…Similar to mammals, Drosophila exposed to cocaine display dose-dependent changes in motor behavior that include increased grooming and locomotion, stereotypic and erratic movements, as well as akinesia, seizures, and death at higher doses (McClung and Hirsh, 1998). Cocaine also reduces sleep in Drosophila (Lebestky et al, 2009), as it does in mammals (Bjorness and Greene, 2021). Therefore, Drosophila show face-valid responses to cocaine.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Drosophila Cocaine Avoidance is Mediated by Peripheral Bitter Gustatory Neurons

Philyaw

Titos

Cummins

et al. 2022

Preprint

View full text Add to dashboard Cite

Genetic variation contributes to heterogeneity in the prevalence of complex disorders such as addiction. The genetic risk for developing a substance use disorder can vary between drugs. The estimated heritability rate of cocaine addiction is 72%, higher than any other drug. Despite recognition of this significant genetic component, little is known about the specific genes and mechanisms that lead to the development of cocaine addiction. Drosophila is an effective model organism for identifying the genes that underlie complex behaviors, including addiction. While Drosophila exposed to cocaine display features of intoxication similar to those observed in mammals, there is currently no model of cocaine self-administration in flies. Because cocaine is a natural insecticide, we wondered if Drosophila might naively avoid it through bitter chemosensory detection. To answer this question, we performed cocaine consumption and preference assays comparing wild-type flies and bitter-taste mutants. Our results demonstrate that Drosophila detect and avoid cocaine through bitter sensing gustatory neurons, and that this process requires gustatory receptor 66a (Gr66a). Additionally, we identify a peripheral mechanism of avoidance through cocaine detection with Drosophila legs. Our findings reveal that preingestive mechanisms of toxin detection play a significant role in Drosophila cocaine avoidance and provide evidence that disrupting gustatory perception of cocaine is essential to for self-administration and therefore, developing a model of self-administration in Drosophila.

show abstract

“…Cocaine also reduces sleep in Drosophila (Lebestky et al, 2009), as it does in mammals (Bjorness and Greene, 2021). Therefore, Drosophila show face-valid responses to cocaine.…”

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Drosophila Cocaine Avoidance is Mediated by Peripheral Bitter Gustatory Neurons

Philyaw

Titos

Cummins

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…On the other hand, the functional role of DNA methylation in gene expression remains an important and challenging issue to address. While many genes involved in functions such as circadian rhythms, learning and memory processes, arousal and appetite or satiety are modulated by drugs of abuse and natural reinforcers, some of them, to some extent, are also Dnmts and/or Tets targets [194][195][196]202,203,300,301]. It therefore appears reasonable to hypothesise that some are regulated by DNA methylation, whereas others can be independent of it, notably through one-carbon metabolism.…”

Section: Epigenetic Connection Between Circadian Rhythms and Addictionmentioning

confidence: 99%

Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction

Saad

Zwiller

Kalsbeek

et al. 2021

Genes

View full text Add to dashboard Cite

Based on studies describing an increased prevalence of addictive behaviours in several rare sleep disorders and shift workers, a relationship between circadian rhythms and addiction has been hinted for more than a decade. Although circadian rhythm alterations and molecular mechanisms associated with neuropsychiatric conditions are an area of active investigation, success is limited so far, and further investigations are required. Thus, even though compelling evidence connects the circadian clock to addictive behaviour and vice-versa, yet the functional mechanism behind this interaction remains largely unknown. At the molecular level, multiple mechanisms have been proposed to link the circadian timing system to addiction. The molecular mechanism of the circadian clock consists of a transcriptional/translational feedback system, with several regulatory loops, that are also intricately regulated at the epigenetic level. Interestingly, the epigenetic landscape shows profound changes in the addictive brain, with significant alterations in histone modification, DNA methylation, and small regulatory RNAs. The combination of these two observations raises the possibility that epigenetic regulation is a common plot linking the circadian clocks with addiction, though very little evidence has been reported to date. This review provides an elaborate overview of the circadian system and its involvement in addiction, and we hypothesise a possible connection at the epigenetic level that could further link them. Therefore, we think this review may further improve our understanding of the etiology or/and pathology of psychiatric disorders related to drug addiction.

show abstract

“…We hypothesized that repeated cocaine would impair sleep homeostasis based on the shift from homeostasis to allostasis under chronic SD ( Kim et al, 2012 ; Clasadonte et al, 2014 ). We did not formulate specific hypotheses to the particular degree of sleep disturbance and its pattern across time, though sleep disturbance during the cocaine exposure period and recovery during the 35 days forced abstinence period was expected based on reports of sleep/waking behavior at various time points in cocaine-dependent human users and cocaine-experienced animals (for review, Bjorness and Greene, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…For example, in rodents receiving experimenter-injected cocaine daily for 10 days, the sleep disturbance-sleep rebound pattern persisted ( Dugovic et al, 1992 ), while in non-human primates self-administering cocaine, measures such as sleep efficiency showed tolerance over time ( Cortes et al, 2016 ) suggesting time or experience-dependent effects independent of the direct pharmacological action. Inconsistent sleep-related outcomes are also observed in human subjects during both active use and withdrawal/abstinence periods (for review, Bjorness and Greene, 2021 ). This inconsistency in sleep-related outcomes following chronic cocaine may be due to a variety of methodological issues, such as timing relative to the sleep period, route of administration, polydrug exposure or history, and the population used as the control to name a few.…”

Section: Introductionmentioning

confidence: 99%

Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice

Bjorness

Greene

2022

Front. Neurosci.

Self Cite

View full text Add to dashboard Cite

Acute cocaine disturbs sleep on a dose-dependent basis; however, the consequences of chronic cocaine remain unclear. While the arousal promotion following cocaine has been well-established, effects of cocaine on sleep after termination of chronic cocaine exposure appear variable in human subjects with few studies in non-human subjects. Here, a within-subjects design (outcomes normalized to baseline, undisturbed behavior) and between-subjects design (repeated experimenter-administered cocaine vs. experimenter-administered saline) was used to investigate sleep homeostasis and sleep/waking under repeated cocaine/saline exposure and prolonged forced abstinence conditions in mice. Overall, during the forced abstinence period increases in arousal, as determined by sleep latency and gamma energy, persisted for 2 weeks. However, the sleep response to externally enforced sleep deprivation was unchanged suggesting that sleep disruptions during the forced abstinence period were driven by enhancement of arousal in the absence of changes in sleep homeostatic responses.

show abstract

Interaction between cocaine use and sleep behavior: A comprehensive review of cocaine's disrupting influence on sleep behavior and sleep disruptions influence on reward seeking

Cited by 17 publications

References 166 publications

Drosophila Cocaine Avoidance is Mediated by Peripheral Bitter Gustatory Neurons

Drosophila Cocaine Avoidance is Mediated by Peripheral Bitter Gustatory Neurons

Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction

Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice

Contact Info

Product

Resources

About