Alleviation of neurological disease by RNA editing

Zhang, Shaochong; Chen, Lu; Zhang, Yining; Dong, Fang

doi:10.1016/j.ymeth.2021.04.023

Cited by 5 publications

(1 citation statement)

References 43 publications

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“…Concerning nucleic acid-based therapy, RNA therapy has shown promising results in treating several human malignances [ 98 , 99 , 100 ], including viral diseases [ 101 ]. There are different approaches to targeting RNA in the human body: antisense oligonucleotides (ASOs) [ 102 ], microRNAs (miRNAs) [ 103 ], small interfering RNAs (siRNAs) [ 104 ], RNA vaccines [ 105 , 106 ], and CRISPR/Cas systems [ 101 ], among others.…”

Section: The Landscape Of Nucleic Acid-based Therapies In Sars-cov-2mentioning

confidence: 99%

Transcriptomics and RNA-Based Therapeutics as Potential Approaches to Manage SARS-CoV-2 Infection

Arriaga-Canon

Contreras-Espinosa

Rebollar-Vega

et al. 2022

IJMS

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SARS-CoV-2 is a coronavirus family member that appeared in China in December 2019 and caused the disease called COVID-19, which was declared a pandemic in 2020 by the World Health Organization. In recent months, great efforts have been made in the field of basic and clinical research to understand the biology and infection processes of SARS-CoV-2. In particular, transcriptome analysis has contributed to generating new knowledge of the viral sequences and intracellular signaling pathways that regulate the infection and pathogenesis of SARS-CoV-2, generating new information about its biology. Furthermore, transcriptomics approaches including spatial transcriptomics, single-cell transcriptomics and direct RNA sequencing have been used for clinical applications in monitoring, detection, diagnosis, and treatment to generate new clinical predictive models for SARS-CoV-2. Consequently, RNA-based therapeutics and their relationship with SARS-CoV-2 have emerged as promising strategies to battle the SARS-CoV-2 pandemic with the assistance of novel approaches such as CRISPR-CAS, ASOs, and siRNA systems. Lastly, we discuss the importance of precision public health in the management of patients infected with SARS-CoV-2 and establish that the fusion of transcriptomics, RNA-based therapeutics, and precision public health will allow a linkage for developing health systems that facilitate the acquisition of relevant clinical strategies for rapid decision making to assist in the management and treatment of the SARS-CoV-2-infected population to combat this global public health problem.

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