Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

Abulizi, Abudumijiti; Hu, Ling; Ma, Ang; Shao, Fangyu; Zhu, Hui-ze; Lin, Simei; Shao, Guangying; Xu, Yue; Ran, Jianhua; Li, Jing; Zhou, Hong; Lin, Dongmei; Wang, Lian-fu; Li, Min; Yang, Baoxue

doi:10.1038/s41401-021-00669-6

Cited by 21 publications

(12 citation statements)

References 74 publications

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“…Yifei Sanjie pills (YFSJ), also known as “ Yiqi Chutan Tang ,” is a TCM formula used to treat lung cancer as complementary and alternative medicine, which consists of Panax quinquefolius Radix (Xi yang shen), Ranunculi Ternati Radix (Mao zhao cao), Sarcandrae Herba (Zhong jie feng), Pinelliae Rhizoma Praeparatum (Fa ban xia), Ganoderma (Ling zhi), Bombyx batryticatus (Chao jiang can), Cremastrae Pseudobulbus Pleiones Pseudobulbus (Shan ci gu), and Fritillariae Thunbergii Bulbus (Zhe bei mu). Previous studies reported that the major herbs of YFSJ, such as Panax quinquefolius Radix and Ganoderma, have been approved for anti-CRF effects in the clinic and preclinic studies due to the inhibition of oxidative stress and the improvement of mitochondrial function in skeletal muscles [ 25 – 32 ]. Phytochemicals absorbed from Thunbergii Bulbus , Bombyx batryticatus, and Pinelliae Rhizoma Praeparatum could also reduce oxidative stress by decreasing free radical formation and scavenging free radicals [ 33 – 35 ], which were commonly associated with fatigue.…”

Section: Introductionmentioning

confidence: 99%

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Chemotherapy-related fatigue (CRF), one of the most severe adverse effects observed in cancer patients, has been theoretically related to oxidative stress, and antioxidant treatment might be one of the most valuable therapeutic approaches. However, there are still few effective pharmacological therapies. Yifei Sanjie pills (YFSJ), a classical formula used to treat lung cancer as complementary and alternative medicine, have been proved to alleviate CRF of lung cancer patients in clinical practices. However, the underlying mechanisms have not been clarified. In this study, our data showed that YFSJ alleviated CRF presented as reversing the decline of swimming time and locomotor activity induced by cisplatin (DDP). Moreover, YFSJ significantly reduces the accidence of mitophagy and mitochondrial damage and reduces apoptosis in skeletal muscle tissues caused by DDP. It probably works by decreasing the oxidative stress, inhibiting the activation of the AMPK/mTOR pathway, decreasing protein expression levels of Beclin1 and other autophagy-related proteins, and attenuating the activation of Cytochrome c (cyto. C), Cleaved Caspase-9 (c-Casp 9), and other apoptosis-related proteins. Furthermore, YFSJ enhanced DDP sensitivity by specifically promoting oxidative stress and activating apoptosis and autophagy in the tumor tissues of mice. It was also found that YFSJ reduced the loss of body weight caused by DDP, reversed the ascent of serum concentrations of alanine aminotransferase (ALT), aminotransferase (AST), and creatinine (CREA), increased the spleen index, and prolonged the survival time of mice. Taken together, these results revealed that YFSJ could alleviate CRF by reducing mitophagy and apoptosis induced by oxidative stress in skeletal muscle; these results also displayed the effects of YFSJ on enhancing chemotherapy sensitivity, improving quality of life, and prolonging survival time in lung cancer mice received DDP chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Chen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Accumulating evidence has demonstrated that polysaccharides [ 4 ], triterpenoids [ 5 ] and ganoderma acids [ 6 ] from G. lucidum have good preventive effects on non-alcoholic fatty liver and hyperlipidemia. Ganoderic acids (GA) belonging to triterpenoids are the most important bioactive components in the G. lucidum fruiting body, and have been proved to have an extensive range of pharmacological features including antitumor, antioxidant, immunomodulatory, hypocholesterolemic, antimicrobial, anti-inflammatory, hypoglycemic and hypolipidemic properties [ 7 , 8 ]. It has been previously revealed that oral administration of G. lucidum ethanol extract (mainly consisting of ganoderic acids) ameliorated hyperlipidemia by regulating the expressions of key genes related to lipid and cholesterol metabolism.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake

Cao

Huang

You

et al. 2022

Foods

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This study aimed to investigate the protective effects of ganoderic acids (GA) from Ganoderma lucidum against liver injury and intestinal microbial disorder in mice with excessive alcohol intake. Results showed GA supplement significantly inhibited the abnormal elevation of the liver index, serum lipid parameters, aspartate aminotransferase and alanine aminotransferase in mice exposed to alcohol intake, and also significantly protected the excessive lipid accumulation and pathological changes. Alcohol-induced oxidative stress in the liver was significantly ameliorated by GA intervention through reducing the levels of maleic dialdehyde and lactate dehydrogenase and increasing the levels of glutathione, catalase, superoxide dismutase and alcohol dehydrogenase. Intestinal microbiota profiling demonstrated GA intervention modulated the composition of intestinal microflora by increasing the levels of Lactobacillus, Faecalibaculum, Romboutsia, Bifidobacterium and decreasing the Helicobacter level. Furthermore, liver metabolomic profiling suggested GA intervention had a remarkable regulatory effect on liver metabolism with excessive alcohol consumption. Moreover, GA intervention regulated mRNA levels of alcohol metabolism, fatty lipid metabolism, oxidative stress, bile acid biosynthesis and metabolism-related genes in the liver. Conclusively, these findings demonstrate GA intervention can significantly relieve alcoholic liver injury and it is hopeful to become a new functional food ingredient for the prevention of alcoholic liver injury.

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“…For DNAzymes treatment, the mice were treated 2 times per week for 6 weeks by the way of center-intratumoral direct injection at a dose of 4 µM of DNAzymes mixed with Lipofectamine 2000. For 5-FU treatment, 5-FU (30 mg/kg) was injected intraperitoneally 2 times per week for 6 weeks [ 21 , 22 ]. The prepared DNAzyme-Lipofectamine mixture (4 µM) was directly injected into the xenografts to enhance local antitumor activity.…”

Section: Methodsmentioning

confidence: 99%

Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis

Guo

Meng

et al. 2022

BMC Pharmacol Toxicol

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Background RNA-cleaving deoxyribozymes (DNAzymes) are catalytic deoxyribonucleic acid molecules that have become a promising new class of gene suppressors by binding and cleaving target mRNA. This study investigated whether DNAzymes targeting Bcl-xL enhanced the effectiveness of radiotherapy and chemotherapy in colorectal cancer (CRC) cells. Methods Two types of CRC cells, SW480 and SW837, were transfected with five DNAzymes. Cell viability, Bcl-xL expression and apoptosis were examined. SW480 xenograft model was used to examine the combined effects of Bcl-xL DNAzymes and 5-FU (or X-rays) on tumor growth. Results Three Bcl-xL DNAzymes, DT882, DT883, and DT884 were identified to be effective in suppressing Bcl-xL expression and causing cell apoptosis. Furthermore, DT882 combined with 5-FU or radiotherapy addictively promoted cell apoptosis and significantly inhibited the growth of SW480 xenografts in vivo. Conclusions These results suggest that Bcl-xL DNAzymes can enhance the radiosensitivity and chemosensitivity in CRC cells via inducing apoptosis.

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Ganoderic acid alleviates chemotherapy-induced fatigue in mice bearing colon tumor

Cited by 21 publications

References 74 publications

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

Yifei sanjie Pills Alleviate Chemotherapy-Related Fatigue by Reducing Skeletal Muscle Injury and Inhibiting Tumor Growth in Lung Cancer Mice

The Protective Effects of Ganoderic Acids from Ganoderma lucidum Fruiting Body on Alcoholic Liver Injury and Intestinal Microflora Disturbance in Mice with Excessive Alcohol Intake

Bcl-xL DNAzymes promote radiosensitivity and chemosensitivity in colorectal cancer cells via enhancing apoptosis

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