The Effect of Broccoli Sprout Extract on Seasonal Grass Pollen-Induced Allergic Rhinitis

Abstract

Patients exposed to pollutants are more likely to suffer from allergic rhinitis and may benefit from antioxidant treatment. Our study determined if patients diagnosed with grass-induced allergic rhinitis could benefit from broccoli sprout extract (BSE) supplementation. In total, 47 patients were confirmed with grass-induced allergic rhinitis and randomized to one of four groups: group 1 (nasal steroid spray + BSE), group 2 (nasal steroid spray + placebo tablet), group 3 (saline nasal spray + BSE) and group 4 (saline nasal spray + placebo tablet). Peak Nasal Inspiratory Flow (PNIF), Total Nasal Symptoms Scores (TNSS) and nasal mucus cytokine levels were analyzed in samples collected before and after the 3-week intervention. Comparing before and after the intervention, PNIF improved significantly when comparing Groups 1 and 2, vs. placebo, at various time points (p ≤ 0.05 at 5, 15, 60 and 240 min) following nasal challenge, while TNSS was only statistically significant at 5 (p = 0.03), 15 (p = 0.057) and 30 (p = 0.05) minutes. There were no statistically significant differences in various cytokine markers before and after the intervention. Combining nasal corticosteroid with BSE led to the most significant improvement in objective measures.

Investigation of the physicochemical, antioxidant, rheological, and sensory properties of ricotta cheese enriched with free and nano‐encapsulated broccoli sprout extract

“…Broccoli sprouts are a rich source of natural antioxidant compounds such as vitamins, carotenoids, minerals, sulfur compounds, and glucoraphanin (especially sulforaphane) (Kikuchi et al, 2021 ). Sulforaphane is an important bioactive compound found in different parts of broccoli that exhibits considerable and significant anti‐inflammatory and antioxidant activities (Yusin et al, 2021 ). In previous studies, the antioxidant activity and health effects of broccoli and sulforaphane as its bioactive compound have been approved (Cedrowski et al, 2021 ; González et al, 2021 ; Tian et al, 2017 ).…”

“…Sulforaphane is an important bioactive compound found in different parts of broccoli that exhibits considerable and significant anti-inflammatory and antioxidant activities (Yusin et al, 2021). In previous studies, the antioxidant activity and health effects of broccoli and sulforaphane as its bioactive compound have been approved (Cedrowski et al, 2021;González et al, 2021;Tian et al, 2017).…”

Nutraceutical Aid for Allergies – Strategies for Down-Regulating Mast Cell Degranulation

“…[68][69][70][71][72] Lipoic acid has been found to be protective in rodent models of anaphylaxis, lessening histamine release, [73][74][75] In a controlled clinical trial, ingestion of BSE was shown to benefit allergic rhinitis symptoms; another clinical study concluded that BSE ameliorated the nasal allergic response to inhalation of diesel exhaust particles. 76,77 Melatonin can promote phase 2 induction by increasing Nrf2 expression; also, via induction of Sirt1, it can boost AMPK activity while antagonizing the NF-kappaB-mediated phase of mast cell activation. [78][79][80] It has shown efficacy in ovalbumin-induced allergic rhinitis in rats, and has been found to suppress mast cell degranulation provoked by water avoidance stress.…”

Oxidative Stress and Antioxidant Pathway in Allergic Rhinitis

“…Therefore, current literature is somewhat limited in defining the complex and diverse molecular pathways of oxidative stress specific to allergic rhinitis. Recent studies which dealt with those dietary antioxidants in allergic rhinitis were reviewed, and the details, including the natural diet source of each antioxidant, are described in Table 1 [ 77 , 82 , 83 , 89 , 94 , 95 , 96 , 97 , 98 ].…”

“…This was the first study to show that nasal epithelial cell barrier dysfunction in allergic rhinitis can be inhibited by activation of the Nrf2 pathway by sulforaphane treatment. Additionally, in a double-blinded, randomized, placebo-controlled clinical trial, sulforaphane showed effects in decreasing T2 cytokines such as IL-4, IL-5, and IL-13 in nasal cavity mucus of allergic rhinitis patients [ 94 ]. Subjective and objective parameters of allergic rhinitis such as total nasal symptom score (TNSS) and peak nasal inspiratory flow (PNIF) were improved after 3 weeks of sulforaphane treatment.…”