Abstract:Although l-carnitine alleviated white-matter lesions in an experimental study, the treatment effects of l-carnitine on white-matter microstructural damage and cognitive decline in hemodialysis patients are unknown. Using novel diffusion magnetic resonance imaging (dMRI) techniques, white-matter microstructural changes together with cognitive decline in hemodialysis patients and the effects of l-carnitine on such disorders were investigated. Fourteen hemodialysis patients underwent dMRI and laboratory and neuro… Show more
“…Another interesting finding is that L-carnitine may serve a neuroprotective role against white matter microstructural damage and cognitive impairment in hemodialysis patients, according to Ueno et al [ 8 ]. Long-term administration of carnitine may ameliorate damage to white matter microstructure by suppressing neuroinflammation and improving the executive function and attention associated with the protection of several candidate fiber tracts.…”
“…Another interesting finding is that L-carnitine may serve a neuroprotective role against white matter microstructural damage and cognitive impairment in hemodialysis patients, according to Ueno et al [ 8 ]. Long-term administration of carnitine may ameliorate damage to white matter microstructure by suppressing neuroinflammation and improving the executive function and attention associated with the protection of several candidate fiber tracts.…”
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