Colistin resistance genes mcr-1 to mcr-5, including a case of triple occurrence (mcr-1, -3 and -5), in Escherichia coli isolates from faeces of healthy pigs, cattle and poultry in Belgium, 2012–2016

Michaël, Timmermans; Wattiau, Pierre; Denis, Olivier; Boland, Cécile

doi:10.1016/j.ijantimicag.2021.106350

Cited by 23 publications

(15 citation statements)

References 34 publications

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“…The genes observed in this collection were mcr-1 to -5. This study found a triple occurrence (mcr-1, mcr-3, mcr-5); the occurrence of multiple mcr genes in a single isolate has been rarely found in other studies and countries [107].…”

Section: Belgiumcontrasting

confidence: 59%

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Colistin Resistant mcr Genes Prevalence in Livestock Animals (Swine, Bovine, Poultry) from a Multinational Perspective. A Systematic Review

Valiakos

Kapna

2021

Veterinary Sciences

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The objective of this review is to collect and present the results of relevant studies on an international level, on the subject of colistin resistance due to mcr genes prevalence in livestock animals. After a literature search, and using PRISMA guidelines principles, a total of 40 swine, 16 bovine and 31 poultry studies were collected concerning mcr-1 gene; five swine, three bovine and three poultry studies referred to mcr-2 gene; eight swine, one bovine, two poultry studies were about mcr-3 gene; six swine, one bovine and one poultry manuscript studied mcr-4 gene; five swine manuscripts studied mcr-5 gene; one swine manuscript was about mcr-6, mcr-7, mcr-8, mcr-9 genes and one poultry study about mcr-10 gene was found. Information about colistin resistance in bacteria derived from animals and animal product foods is still considered limited and that should be continually enhanced; most of the information about clinical isolates are relative to enteropathogens Escherichia coli and Salmonella spp. This review demonstrates the widespread dispersion of mcr genes to livestock animals, indicating the need to further increase measures to control this important threat for public health issue.

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Section: Belgiumcontrasting

confidence: 59%

“…The study showed that all isolates carried at least one mcr gene. Only one mcr-1 gene was detected in a broiler chicken sample [107].…”

Section: Belgiummentioning

confidence: 95%

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Colistin Resistant mcr Genes Prevalence in Livestock Animals (Swine, Bovine, Poultry) from a Multinational Perspective. A Systematic Review

Valiakos

Kapna

2021

Veterinary Sciences

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“…The prophylactic use of colistin as a feed additive before 2016 has resulted in a significant increase in the rate of colistin resistance among organisms isolated from livestock and poultry farms in China (Shen et al, 2016 ). Food-producing animals have been considered a major reservoir of mcr - 1 -carrying bacteria (Liu et al, 2016 ; Yi et al, 2017 ; Moon et al, 2021 ; Sevilla et al, 2021 ; Timmermans et al, 2021 ). In this regard, pork has been considered one of the major contamination sources of mcr-1 -harboring Salmonella (Hu et al, 2019 ; Lu et al, 2019 ; Elbediwi et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Genomic Characterization of mcr-1-Carrying Foodborne Salmonella enterica serovar Typhimurium and Identification of a Transferable Plasmid Carrying mcr-1, blaCTX-M-14, qnrS2, and oqxAB Genes From Ready-to-Eat Pork Product in China

Li¹,

Wan²,

Olsen³

et al. 2022

Front. Microbiol.

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Salmonella enterica resistant to colistin, third-generation cephalosporins (3GCs), and fluoroquinolones (FQs) has been deemed a high-priority pathogen by the World Health Organization (WHO). The objective of this study was to characterize 11 mcr-1-harboring Salmonella enterica serovar Typhimurium isolates from raw pork and ready-to-eat (RTE) pork products in Guangzhou, China. All isolates were multi-drug resistant and contained 6–24 antibiotic-resistant genes. The mcr-1 gene was localized in the most conserved structure (mcr-1-orf ) in eight isolates and in mobile structure (ISApl1-mcr-1-orf ) in three isolates. One raw pork isolate SH16SF0850, co-harbored mcr-1, blaCTX−M−14, and oqxAB genes. One isolate 17Sal008 carried mcr-1, blaCTX−M−14, qnrS2, and oqxAB genes located on a 298,622 bp IncHI2 plasmid pSal008, which was obtained from an RTE pork product for the first time. The pSal008 was closely related to a plasmid in an S. typhimurium isolate from a 1-year-old diarrheal outpatient in China and was found to be transferable to Escherichia coli J53 by conjugation. Genome sequence comparisons by core-genome Multi Locus Sequence Typing (cgMLST) based on all S. typhimurium isolates from China inferred highly probably epidemiological links between selected pork isolates and no possible epidemiologically links between RTE pork isolate 17Sal008 and other isolates. Our findings indicate that raw pork and pork products are potential reservoirs of mcr-1-harboring S. typhimurium and highlight the necessity for continuous monitoring of colistin, 3GCs, and FQs resistant S. typhimurium from different origins.

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“…The prophylactic use of colistin as a feed additive before 2016 has resulted in a significant increase in the rate of colistin resistance among organisms isolated from livestock and poultry farms in China (Shen et al, 2016). Food-producing animals have been considered a major reservoir of mcr-1-carrying bacteria (Liu et al, 2016;Yi et al, 2017;Moon et al, 2021;Sevilla et al, 2021;Timmermans et al, 2021). In this regard, pork has been considered one of the major contamination sources of mcr-1harboring Salmonella (Hu et al, 2019;Lu et al, 2019;Elbediwi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

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Colistin resistance genes mcr-1 to mcr-5, including a case of triple occurrence (mcr-1, -3 and -5), in Escherichia coli isolates from faeces of healthy pigs, cattle and poultry in Belgium, 2012–2016

Cited by 23 publications

References 34 publications

Colistin Resistant mcr Genes Prevalence in Livestock Animals (Swine, Bovine, Poultry) from a Multinational Perspective. A Systematic Review

Colistin Resistant mcr Genes Prevalence in Livestock Animals (Swine, Bovine, Poultry) from a Multinational Perspective. A Systematic Review

Genomic Characterization of mcr-1-Carrying Foodborne Salmonella enterica serovar Typhimurium and Identification of a Transferable Plasmid Carrying mcr-1, blaCTX-M-14, qnrS2, and oqxAB Genes From Ready-to-Eat Pork Product in China

Data_Sheet_1.DOCX

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