Development of Auditory Cortex Circuits

Chang, Minzi

doi:10.1007/s10162-021-00794-3

Cited by 12 publications

(6 citation statements)

References 304 publications

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“…If OME occurs in infants under four, it can affect auditory sensitivity [14]. Any disruption in auditory input during the critical developmental period of central auditory system plasticity in childhood can lead to impaired auditory cortex development and other developmental irregularities [15]. This study aimed to determine whether otitis media is prevalent within adenoid hypertrophy diagnosed children.…”

Section: Discussionmentioning

confidence: 99%

The ear-adenoid nexus: Unraveling the impact of adenoid hypertrophy size on asymptomatic otitis media effusion

Md. Masum Billah,

Farzana Binte Abedin Leera

2023

Int. J. Sci. Res. Arch.

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Introduction: Adenoid hypertrophy may lead to a condition called Otitis Media with Effusion (OME). However, hearing loss caused by OME is frequently overlooked and remains asymptomatic in children. This oversight can have adverse effects on cognitive development and academic performance. Aim: To estimate the frequency of asymptomatic OME in children with adenoid hypertrophy and to find the association between adenoid size and occurrence of OME. Materials and Methods: This cross-sectional observational study was conducted at a tertiary care center in Mirzapur, Tangail, Bangladesh, with 124 patients spanning from April 2023 to September 2023. The study focused on children aged 5 to 12 who displayed adenoid hypertrophy symptoms but had not reported any hearing issues. It involved a thorough clinical examination of the ear, nose, and throat. Additionally, all patients underwent tympanometry. Adenoid size was assessed by using nasal endoscopy and radiographs using Mc Murray and Clements scale. The prevalence of OME was expressed as a percentage, and Fisher's exact test was utilized to analyze the relationship between adenoid size and the presence of asymptomatic OME. Results: Data from 154 cases of adenoid hypertrophy were analyzed. The commonest age of presentation was 5-8 years (66.9%). Otoscopy found that 71 individuals (equivalent to 56.26%) had a normal tympanic membrane on both sides. And the majority (13.7%) had bilateral air-fluid levels. 67.7% of participants with adenoid hypertrophy had no effusion, and 32.3% had otitis media with effusion. This connection between endoscopic and radiological adenoid size and OME was statistically significant, with a p-value of less than 0.05. Impedance audiometry showed that most candidates (52.8%) presented with a 'B' type tympanogram. That indicates many participants with OME were not identified clinically but diagnosed by impedance audiometry. Conclusion: There was an association between adenoid size and the occurrence of OME. Among the study participants, approximately 32.3% were clinically identified as having asymptomatic OME.

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Section: Discussionmentioning

confidence: 99%

The ear-adenoid nexus: Unraveling the impact of adenoid hypertrophy size on asymptomatic otitis media effusion

Md. Masum Billah,

Farzana Binte Abedin Leera

2023

Int. J. Sci. Res. Arch.

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“…The timing of inner ear interventions in mouse models for congenital profound deafness is therefore problematic. In humans, hearing onset occurs in utero, at about 4.5 months of gestation 81 whereas mice are born deaf and do not begin to hear until postnatal day 12 (P12). The maturation of the human cochlea is well-advanced at midgestation and complete at birth, with only subtle refinements of some structures occurring thereafter 82 .…”

Section: [H2] Challenges Posed By Inner Ear Therapymentioning

confidence: 99%

Deafness: from genetic architecture to gene therapy

2023

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Progress in deciphering the genetic architecture of human sensorineural hearing impairment (SNHI), also commonly referred to as sensorineural hearing loss (SNHL) and multidisciplinary studies of mouse models have led to the elucidation of the molecular mechanisms underlying auditory system function, primarily in the cochlea, the mammalian hearing organ. These studies have provided unparalleled insights

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“…Each of these SpN‐specific molecular markers has different functional roles in neurological processes (see Review for CTGF: Chen et al., 2020; Perbal, 2004; Ramazani et al., 2018; Drd1a: Antunes & Malmierca, 2021; Jones‐Tabah et al., 2022; Nishi et al., 2011, and Nxph4: Wilson et al., 2019), but their mRNA or protein expression can be detected during early postnatal period (Hoerder‐Suabedissen & Molnár, 2013; Hoerder‐Suabedissen et al., 2013), making them ideal candidates in this study. In addition, the different sensory areas develop at different times (Chang & Kanold, 2021; Chang et al., 2018; Ignacio et al., 1995), we speculated that the expression of SpN markers would also vary across areas; we compared ACtx with the SCtx and visual cortex (VCtx).…”

Section: Introductionmentioning

confidence: 99%

Distinct distribution of subplate neuron subtypes between the sensory cortices during the early postnatal period

Chang,

Nehs,

et al. 2024

J of Comparative Neurology

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Subplate neurons (SpNs) are a heterogeneous neuronal population actively involved in early cortical circuit formation. In rodents, many SpNs survive and form layer 6b. The molecular heterogeneity of SpNs raises the question of whether different subpopulations of SpNs survive through the early postnatal period similarly and whether such diverse SpN populations in the auditory cortex (ACtx) share a common distribution pattern with other sensory systems. To address that, we investigated the expression pattern of multiple specific SpN markers in the ACtx, as well as in the visual (VCtx) and somatosensory (SCtx) cortices as controls, using complexin 3 (Cplx3) antibodies and different SpN‐specific Cre‐driver mice, such as connective tissue growth factor (CTGF), dopamine receptor D1 (Drd1a), and neurexophilin 4 (Nxph4). We focused on two early time windows in auditory development: (1) during the second postnatal week (PNW) before ear‐canal opening and (2) during the third PNW after ear‐canal opening. We compared the expression pattern of different SpN markers in ACtx with VCtx and SCtx. At both examined timepoints, Cplx3 and Nxph4 expressing SpNs form the largest and smallest population in the ACtx, respectively. Similar distribution patterns are observable in the VCtx and SCtx during the second PNW but not during the third PNW, for a higher proportion of Drd1a expressing SpNs is detected in the VCtx and CTGF expressing SpNs in the SCtx. This study suggests that different populations of SpNs might contribute differently to the development of individual sensory circuits.

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Development of Auditory Cortex Circuits

Cited by 12 publications

References 304 publications

The ear-adenoid nexus: Unraveling the impact of adenoid hypertrophy size on asymptomatic otitis media effusion

The ear-adenoid nexus: Unraveling the impact of adenoid hypertrophy size on asymptomatic otitis media effusion

Deafness: from genetic architecture to gene therapy

Distinct distribution of subplate neuron subtypes between the sensory cortices during the early postnatal period

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