Overview of Diffusion Tensor, Diffusion Kurtosis, and Q-space Imaging and Software Tools

Hasan, Khader M.; Yamada, Kazuo

doi:10.1016/j.mric.2021.02.003

Cited by 4 publications

(1 citation statement)

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“…The latter highlights a known limitation related to standard DTI, notably that DTI is not able to resolve crossing fibers within brain voxels ( 11 ). To overcome this limitation, more advanced dMRI methods must be used ( 12 ). For example, the distribution of fiber orientations (i.e., fiber orientation distribution, FOD) within a voxel can be directly estimated from dMRI data without prior assumptions regarding the number of fiber populations present ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

Structural connectivity and brain network analyses in Parkinson's disease: A cross-sectional and longitudinal study

et al. 2023

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IntroductionParkinson's disease (PD) is an idiopathic disease of the central nervous system characterized by both motor and non-motor symptoms. It is the second most common neurodegenerative disease. Magnetic resonance imaging (MRI) can reveal underlying brain changes associated with PD.ObjectiveIn this study, structural connectivity and white matter networks were analyzed by diffusion MRI and graph theory in a cohort of patients with PD and a cohort of healthy controls (HC) obtained from the Parkinson's Progression Markers Initiative (PPMI) database in a cross-sectional analysis. Furthermore, we investigated longitudinal changes in the PD cohort over 36 months.ResultCompared with the control group, participants with PD showed lower structural connectivity in several brain areas, including the corpus callosum, fornix, and uncinate fasciculus, which were also confirmed by a large effect-size. Additionally, altered connectivity between baseline and after 36 months was found in different network paths inside the white matter with a medium effect-size. Network analysis showed trends toward lower network density in PD compared with HC at baseline and after 36 months, though not significant after correction. Significant differences were observed in nodal degree and strength in several nodes.ConclusionIn conclusion, altered structural and network metrics in several brain regions, such as corpus callosum, fornix, and cingulum were found in PD, compared to HC. We also report altered connectivity in the PD group after 36 months, reflecting the impact of both PD pathology and aging processes. These results indicate that structural and network metrics might yield insight into network reorganization that occurs in PD.

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Section: Introductionmentioning

confidence: 99%