Hsa_circ_0054633 mediates apoptosis and insulin secretion in human pancreatic β cells through miR-409-3p/caspase-8 axis

Sun, Rui; Xue, Wanli; Zhao, Juzhen

doi:10.1016/j.diabres.2021.108837

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…In addition, this study demonstrated that overexpression of circ-Tulp4 competitively bound to mir-7222-3-p, inhibited the expression of cholesterol esterification-related gene,sterol-o-acyltransferase1(SOAT1), and activated the expression of cyclin D1, thereby enhanced beta-cell proliferation and reduced lipotoxicity-induced beta-cell apoptosis (143). Sun et al revealed (144) that Has-circ-0054633 was abundantly expressed in diabetic and high-glucose-treated beta-cell and that inhibition of Has-circ-0054633 can ameliorate glucotoxicity-induced beta-cell apoptosis and insulin secretion via regulation of miR-409-3p or caspase-8. According to Cheng et al (145) the expression of Hsa-circ-0068087 at high glucose conditions was identified to be upregulated, whereas inhibition of Hsa-circ-0068087 expression can improve the inflammation mediated by TLR4, NF-kB/NLRP3 inflammatory corpuscles under high glucose conditions through competitive binding to miR-197.…”

Section: Circular Rnasmentioning

confidence: 80%

“…Sun et al. revealed ( 144 ) that Has-circ-0054633 was abundantly expressed in diabetic and high-glucose-treated beta-cell and that inhibition of Has-circ-0054633 can ameliorate glucotoxicity-induced beta-cell apoptosis and insulin secretion via regulation of miR-409-3p or caspase-8. According to Cheng et al.…”

Section: Non-coding Rnas and Pancreatic Beta-cell Apoptosismentioning

confidence: 99%

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Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

et al. 2022

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Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancreatic beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. Therefore, in this review, we will focus on the current status and progress of research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide new ideas for T2DM treatment strategies.

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Section: Circular Rnasmentioning

confidence: 80%

Section: Non-coding Rnas and Pancreatic Beta-cell Apoptosismentioning

confidence: 99%

Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

et al. 2022

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“…In addition, Hsa_circ_0054633 suppression promotes β-cell proliferation and facilitates insulin secretion through inhibiting caspase-8 expression by sponging miR-409-3p. 274 These recent results point to circRNAs as novel regulators of β-cell dysfunction under diabetic conditions.…”

Section: The Insulin Signaling and Irmentioning

confidence: 98%

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

Chi²,

Wang

et al. 2022

Sig Transduct Target Ther

228

132

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The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition. Insulin is a key peptide hormone and mediates the systemic glucose metabolism in different tissues. Insulin resistance (IR) is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target tissues. Acquired conditions and genetic factors have been implicated in IR. Recent genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines, cytokines, chemokines, excess lipids and toxic lipid metabolites promote IR in other tissues. IR is associated with several groups of abnormal syndromes that include obesity, diabetes, metabolic dysfunction-associated fatty liver disease (MAFLD), cardiovascular disease, polycystic ovary syndrome (PCOS), and other abnormalities. Although no medication is specifically approved to treat IR, we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity. Ultimately, the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR.

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“…13,14 After consulting literatures, hsa-miR-607, hsa-miR-29a-5p, hsa-miR-3690, and hsa-miR-409-3p were determined to conduct further research. [14][15][16][17] Subsequently, the lncRNA interacting with the related miRNAs which were selected above was predicted by starBase and Diana-lncRNABase(http://carolina.imis.athena-innovation.gr/ diana_tools/web/) bioinformatics. Using Venn diagrams to get their intersection.…”

Section: Candidate Circrna and Target Mirna And Lncrna Predictionmentioning

confidence: 99%

hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus

et al. 2022

Exp Biol Med (Maywood)

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Type 2 diabetes mellitus (T2DM) is a multifactorial disorder that leads to alterations in gene regulation. ncRNAs have the characteristics of tissue specificity, disease specificity, timing specificity, high stability and post transcriptional regulation effect. These preconditions are more conducive to promote ncRNA to become a new biomarker for clinical diagnosis. Our study aims to explore the relationship between circRNA, lncRNA, miRNA and T2DM, and to evaluate their diagnostic value for T2DM. A total of 101 pairs of T2DM and controls were conducted in the study. QRT-PCR was used to study the differential expression of circRNAs, miRNAs and lncRNAs. ROC curve was used to estimate their diagnostic value in T2DM. Compared with healthy controls, the expression levels of hsa_circ_0071106, hsa_circ_0000284, hsa_circ_0071271, hsa-miR-29a-5p, hsa-miR-3690, hsa-miR-607, lncRNA MEG3 and lncRNA TUG1were higher in T2DM (all P < 0.05). The AUCs of hsa_circ_0071106, hsa-miR-607 and lncRNA TUG1 for diagnosis of T2DM were 0.563,0.645 and 0.642, respectively. The combined AUC of hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 was 0.798 ([0.720~0.875], P < 0.001). Moreover, the sensitivity of combined diagnosis was 75.2% and the specificity was 100.0%. The levels of lncRNA TUG1, hsa-miR-607 and hsa_circ_0071106 in peripheral blood have potential clinical diagnostic value for T2DM.

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Hsa_circ_0054633 mediates apoptosis and insulin secretion in human pancreatic β cells through miR-409-3p/caspase-8 axis

Cited by 8 publications

References 17 publications

Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

Trends in insulin resistance: insights into mechanisms and therapeutic strategy

hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus

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