Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats

Dong, Jinhui; Ou, Xiaohong; Wang, Jian-xing; Shan, Chunguang; Ren, Xiumin

doi:10.1080/08923973.2021.1905659

Cited by 50 publications

(27 citation statements)

References 27 publications

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“…Luteolin (LU, 3′,4′,5,7-tetrahydroxylflavone) is a flavonoid found in foods consumed on a daily basis including fruits, vegetables, nuts, and herbs (Kim et al 2000 ). Preclinical studies have shown that LU has various biological and pharmacological activities, such as anti-inflammatory, antitumor, antihepatotoxic, antioxidant, and anti-allergic effects (Chen et al 2017 ; Albarakati et al 2020 ; Dong et al 2021 ). LU reduces oxidative stress in diabetic rats and exerts cardioprotective effects by inhibiting the mitochondrial permeability transition pore (Xiong et al 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder

Sur

Lee

2022

Animal Cells and Systems

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Exposure to severe stress can lead to the development of neuropsychiatric disorders, including post-traumatic stress disorder (PTSD). The cause of PTSD is dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis and an imbalance of monoamines. Fruits and vegetables contain large amounts of luteolin (LU; 3′,4′,5,7-tetrahydroxylflavone), which has various pharmacological activities such as anti-inflammatory, antioxidant, and anti-allergic effects. We investigated the effects of LU on fear, depression, and anxiety following monoamine imbalance and hyperactivation of the HPA axis in rats exposed to single prolonged stress (SPS). Male rats were dosed with LU (10 and 20 mg/kg) once daily for 14 days after exposure to SPS. Administration of LU reduced fear freezing responses to extinction recall and depression- and anxiety-like behaviors, and suppressed increases in plasma corticosterone and adrenocorticotropic hormone levels. Also, administration of LU restored the increased norepinephrine and decreased serotonin levels in the structures within the fear circuit, medial prefrontal cortex, and hippocampus. Our results showed that administration of LU improved freezing behavior according in a situation-dependent manner, and showed anti-depressant and anxiolytic effects. Thus, LU may be a useful therapeutic agent to prevent traumatic stress such as PTSD.

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Section: Introductionmentioning

confidence: 99%

Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder

Sur

Lee

2022

Animal Cells and Systems

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“…The pathogenesis of allergic rhinitis is not very clear. At present, Th1/Th2 imbalance is considered to be the main cause, and there is no fundamental treatment plan for allergic rhinitis [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

A Novel Strategy for the Treatment of Allergic Rhinitis: Regulating Treg/Th17 and Th1/Th2 Balance In Vivo by Vitamin D

Li¹,

Zhang²,

Sun³

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. This prospective study is aimed at observing the number of nasal itching and sneezing in rats from the macroscopic level and examine the pathological changes of nasal mucosa, Th1 and Th2-related cytokines, and Treg/Th17 by vitamin D3 administration from the microscopic level, in order to explore the role of vitamin D in allergic rhinitis and to provide theoretical guidance for prevention and treatment. Results. There were significant differences in nasal itching and sneezing between the administration groups and the positive groups. Meanwhile, the level of Th1 and Treg in the administration groups increased, while the level of Th2 and Th17 decreased, indicating that the balance of Th1/Th2 was corrected. Our study revealed that vitamin D3 has preventive and therapeutic effects on allergic rhinitis, which provides theoretical guidance for practical application.

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“…In our previous study, we identified the active substances contained in cumin seeds that inhibit degranulation in RBL-2H3 cells, i.e., apigenin, luteolin, and umbelliferose [ 30 ]. Apigenin and luteolin have also been reported to attenuate OVA-induced allergic rhinitis [ 31 , 32 , 33 , 34 ]. However, since apigenin and luteolin are practically insoluble in water, they are hardly extracted in CAE.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Extract from Cuminum cyminum L. Seed Alleviates Ovalbumin-Induced Allergic Rhinitis in Mouse via Balancing of Helper T Cells

Ishida

Miyagawa

Nishi

et al. 2022

Foods

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Cuminum cyminum L. (cumin) seeds are widely used as a spice. Although we previously reported that the aqueous extract of cumin seeds suppresses the degranulation of rat basophilic RBL-2H3 cells, it has not been clarified whether the extract alleviates actual allergy symptoms in vivo. Therefore, in this study, we investigated the effect of oral administration of cumin seed aqueous extract (CAE) in ovalbumin (OVA)-induced allergic rhinitis. BALB/c mice were randomly divided into the following three groups: control group (five mice), OVA group (five mice), and OVA + CAE group (five mice). Allergic rhinitis was induced by sensitization (intraperitoneal, 25 μg OVA and 1.98 mg aluminum hydroxide gel) followed by challenge (intranasal, 400 μg OVA). The oral administration of CAE (25 mg/kg) reduced the sneezing frequency of OVA-induced allergic rhinitis model mice. In addition to reducing the serum immunoglobulin E and IL-4 levels, the oral administration of CAE reduced the production of T-helper type-2 (Th2) cytokines (IL-4, IL-5, IL-10, and IL-13) in the splenocytes of the model mice. Furthermore, a significant increase in the ratio of Th1 to Th2 cells was observed in the CAE-administered group. Our findings suggest that the ingestion of CAE improves T cell balance, the dominant state of Th2, and alleviates allergic rhinitis symptoms.

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Luteolin ameliorates inflammation and Th1/Th2 imbalance via regulating the TLR4/NF-κB pathway in allergic rhinitis rats

Cited by 50 publications

References 27 publications

Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder

Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder

A Novel Strategy for the Treatment of Allergic Rhinitis: Regulating Treg/Th17 and Th1/Th2 Balance In Vivo by Vitamin D

Aqueous Extract from Cuminum cyminum L. Seed Alleviates Ovalbumin-Induced Allergic Rhinitis in Mouse via Balancing of Helper T Cells

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