Abstract:INTRODUCTION:
The widespread use of Angiotensin converting enzyme inhibitors (ACEi), especially lisinopril, and their association with colorectal cancer (CRC) has been studied with mixed results. Data suggest angiotensin II inhibition may decrease CRC risk. Contrasting studies suggest a role for kinins in pro-angiogenic effects with their accumulation blunting the effects of angiotensin II inhibition. Since ACEi’s affect both angiotensin II and bradykinin levels, we studied the effect of lisinopril… Show more
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