“…In addition, phosphorylated AMPK (P-AMPK) proteins have been reported to localize to various mitotic structures such as spindle poles, midzones, and midbodies, and kinetochores during mitosis (Vazquez-Martin et al, 2011;Lu et al, 2021). Studies using AMPK-knockdown or knockout mammalian cultured cells and Ampk-null Drosophila melanogaster mutants have revealed a role of AMPK in mitosis, since they have various mitotic defects, such as mitotic delay, chromosome misalignment, spindle misorientation, and chromosome missegregation, such as lagging or polyploid chromosomes (Lu et al, 2021;Thaiparambil et al, 2012;Lee et al, 2007;Stauffer et al, 2019). Mitotic errors are often associated with aneuploidy, defined as the loss or gain of chromosomes, which is found in approximately 90% of tumors and has been proposed to drive cancer progression (Ben-David et al, 2020; Vasudevan et al, 2021).…”