Thrombosis and thrombocytopenia in antiphospholipid syndrome: their association with mean platelet volume and hematological ratios

Llorente-Chávez, Amaya; Martín‐Nares, Eduardo; Núñez‐Álvarez, Carlos A.; Hernández-Molina, Gabriela

doi:10.1016/j.thromres.2021.04.018

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Even so, this finding was in line with several previous studies. 7,11,13,14 According to the ROC curve for the prediction of DVT, the cut-off value for MPV was 13.3 fL with 98.1% sensitivity, and 77.6% specificity. In the crude logistic regression model, we found an inverse association between MPV and the risk of DVT, regardless of whether it was analyzed as a categorical variable (< 13.3 fL) or a continuous variable (per 1.0 fL decrease).…”

Section: Discussionmentioning

confidence: 99%

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Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture

Wang

Chen

et al. 2022

Clin Appl Thromb Hemost

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This study aimed to explore the association between mean platelet volume (MPV) and preoperative deep vein thrombosis (DVT) in older patients with hip fracture. A total of 352 consecutive older patients with hip fracture were included from January 2014 to December 2020. MPV values were measured on admission, and color Doppler ultrasonography was performed for DVT screening before the planned surgery. The receiver operating characteristic (ROC) curve was used to establish the optimal cut-off value for the prediction of DVT. Univariate and multivariate logistic regression analysis were used to examine the association between factors and DVT. The overall prevalence of preoperative DVT was 15.1%, and patients with DVT had a lower value of MPV than non-DVT patients (11.6 ± 1.2 fL vs 12.3 ± 1.4 fL, P < .01). The cut-off point according to the ROC curve for MPV was 13.3 fL, and multivariate logistic regression analysis showed that MPV level < 13.3 fL was significantly associated with an increased risk of DVT (OR = 4.857, 95% CI: 1.091-21.617, P = .038), and with every 1.0 fL decrease in MPV, the risk increased by 27.7% (OR = 1.277, 95% CI: 1.001-1.629, P = .047). Our findings indicate that a low MPV level is associated with DVT in older patients with hip fracture. As MPV is a simple indicator that can be calculated from the blood routine test, it may be a potential biomarker of DVT with the combination of other tests, further studies are needed to confirm these results.

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Section: Discussionmentioning

confidence: 99%

“…8,9 Increasing evidences indicated that MPV was significantly associated with VTE events. [10][11][12][13][14] However, MPV is influenced by age, 15 and few studies have evaluated this relationship in older adults. 16 With an aging worldwide population, hip fractures represent a global public health issue.…”

Section: Introductionmentioning

confidence: 99%

Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture

Wang

Chen

et al. 2022

Clin Appl Thromb Hemost

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Mean platelet volume may not play a role in determining thrombosis development in patients with antiphospholipid syndrome

Beyan

2021

Thrombosis Research

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Patients with antiphospholipid syndrome and a first venous or arterial thrombotic event: clinical characteristics, antibody profiles and estimate of the risk of recurrence

Pengo,

Sarti,

Antonucci

et al. 2024

Clinical Chemistry and Laboratory Medicine (CCLM)

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Objectives Thrombosis in antiphospholipid syndrome (APS) involves in most cases the venous circulation. Why in some patients thrombotic APS affects the arterial circulation and in particular cerebral circulation is unknown. In previous studies, both patient characteristics and antiphospholipid antibody types and titers have been associated with arterial thrombosis. Aim of this study was to compare the clinical characteristics and laboratory findings of venous and arterial thrombotic APS from a large series of patients. Methods Data were retrieved from the Start 2 antiphospholipid, a multicenter prospective register of long-term collected data from Thrombosis Centers in Italy. Results Of 167 patients with thrombotic APS, 114 (68 %) had a venous and 53 (32 %) had an arterial event as first clinical manifestation. Several clinical characteristics and risk factors were different among groups in univariate analysis. Using logistic regression analysis, reduced creatinine clearance and hyperlipidemia were independent variable for the occurrence of arterial APS. Notably, no difference in antiphospholipid antibody profiles and aβ2-Glycoprotein I levels were found between groups. A higher adjusted global antiphospholipid syndrome score (aGAPSS) was found in arterial group indicating a possible high recurrence rate in arterial APS. Conclusions These data have pathophysiological and clinical implication since associated conditions might predispose patients to arterial rather than venous events and call to a close monitoring and treatment of arterial APS due to their increased tendency to recurrence.

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Thrombosis and thrombocytopenia in antiphospholipid syndrome: their association with mean platelet volume and hematological ratios

Cited by 4 publications

References 20 publications

Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture

Low Mean Platelet Volume is Associated with Deep Vein Thrombosis in Older Patients with Hip Fracture

Mean platelet volume may not play a role in determining thrombosis development in patients with antiphospholipid syndrome

Patients with antiphospholipid syndrome and a first venous or arterial thrombotic event: clinical characteristics, antibody profiles and estimate of the risk of recurrence

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