Serial blood sampling effects in rat embryo-fetal development studies for toxicokinetics

Lee, Jin Soo; Jeong, Ji-Seong; Kim, Woojin; Kim, SangYun; Lee, Seung-Jin; Baek, Sang-Ki; Lee, Jae‐Hwan; Jeong, Eun Ju; Nam, Sang-Yoon; Yu, Wook-Joon

doi:10.1016/j.yrtph.2021.104930

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…The dams were examined by noninvasive color Doppler ultrasound by the same person (Mariam Rabie). All examinations were performed using the same ultrasound machine (Esaote MyLab 30X Vision, Esaote, Genova, Italy) with multifrequency probe (6)(7)(8)(9)(10)(11)(12) with a filter of 100 Hz, power of 50%, pulse repetition frequency (PRF) of 4,500 Hz, and Doppler angle ranging from 0 to 40.…”

Section: Experimental Animalsmentioning

confidence: 99%

“…For mechanistic studies of human reproduction, the rat is the most commonly used model. Because of the rat's size, serial blood draws are possible in pharmacological investigations [10] Physiology, pathology, pharmacology, toxicology, and transplantation investigations using the laboratory rat as a model. Because practically every medicine approved for human therapy passes through the bodies of laboratory rats, pharmacological research is extremely valuable.…”

Section: Introductionmentioning

confidence: 99%

“…Because practically every medicine approved for human therapy passes through the bodies of laboratory rats, pharmacological research is extremely valuable. Hundreds of different rat models have been created to replicate pathological and physiological human clinical circumstances, particularly in complicated disorders [10]. Many of the model rats are deposited in rat resource centers, where biomedical researchers can use and share animals and rat-related resources.…”

Section: Introductionmentioning

confidence: 99%

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Uterine Blood Flow Dynamic Changes in Sprague-Dawley Rats During Pregnancy Using Noninvasive Color Doppler Sonography

Rabie,

Sharawy,

ElAdl

et al. 2024

Egyptian Journal of Veterinary Sciences

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Egyptian Journal of Veterinary Sciences https://ejvs.journals.ekb.eg/ T HE present study was designed to evaluate the changes of uterine blood flow changes during pregnancy in Sprague-Dawley. Also, to investigate the clinical applicability of noninvasive color Doppler ultrasound to charactrize the uterine blood flow indices in the maternal uterine arteries in rats. Ten female rats weighing 280-300 gm were used and the Doppler indices were blood flow volume (BFV), time averaged maximum velocity (TAMV), peak systolic velocity (PSV), resistance index (RI), pulsatility index (PI), and diameter (D) of uterine arteries in rats during pregnancy. Examination of the uterine arteries started three days after breeding and continued at days 7, 14 and 18. Based on the noninvasive color doppler sonography, the BFV, TAMV, PSV were increased significantly at all-time points of the examination. On the contrary, the RI and PI decreased steadily at all-time points. The RI and PI showed a significant increase at day 20 of gestation. Altogether, these results indicate that non-invasive Doppler ultrasound parameters provide important information toward understanding changes in the vasculature and its perfusion of the uterus during the pregnancy period in rats. Furthermore, the present results would be key values for the uterine blood flow during pregnancy in Sprague-Dawley.

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