Rare gastric neoplasm: Malignant glomus tumor of the stomach. A case report

Alsahwan, Abdullah G.; Alfaraj, Zainab M.; AlSafwani, Jihad; Bunaiyan, Abdullah H.; AlKhalifah, Ridha H.; Al-Saba'a, Sumayah A.; Al-Momen, Sami; Aldolah, Qassim

doi:10.1016/j.ijscr.2021.105802

Cited by 14 publications

(22 citation statements)

References 20 publications

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“…These results were consistent with the literature report. The diagnosis of malignant GT includes three criteria: moderate to marked nuclear atypia together with mitotic activity of more than 5 mitoses per 50 high power fields, atypical mitotic figure or tumor size greater than 2 cm with deep location [ 14 , 16 ]. The malignant glomus tumor should feature at least one of the first two previously mentioned criteria.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography features and clinicopathological characteristics of gastric glomus tumor

et al. 2022

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Background Gastric glomus tumor (GGT) is a rare neoplasm that is difficult to distinguish from other gastric submucosal tumors due to a lack of diagnostic experience. The goal of this study was to better understand GGT by looking at its clinicopathological features, computed tomography (CT) features, and differential diagnosis. Methods The clinical data and CT findings of 21 pathologically confirmed GGT patients were examined. The clinical characteristics and CT findings of benign GGT were compared to gastric stromal tumors (GST) (n = 30) and heterotopic pancreas (n = 30). Results The 21 cases included six males and fifteen females ranging in age from 42 to 64 years. The lesions were found in the gastric body in four cases and the antrum in seventeen. GGT was diagnosed as benign in 20 cases and malignant in one. In benign cases, the glomus cells were small, uniform, showed perivascular hemangiopericytoma‑like or solid nest‑like structures. Obvious mitotic figures were observed in the malignant case. SMA staining was positive in the tumor cells. A quasi-round or round solid mass protruded into the gastric cavity in 20 benign cases, with a clear and smooth edge. The long to short diameter ratio was 1.01 ± 0.15. All of the benign cases had obvious enhancement, with homogeneous enhancement in ten cases and heterogeneous enhancement in ten cases, as well as central filling enhancement in 12 cases. The ratio of CT value of lesion to abdominal aorta in arterial phase and venous phase were (0.41 ± 0.11) and (0.81 ± 0.20), which were significantly higher than GST and heterotopic pancreas. The irregular mass broke through the gastric wall and invaded liver with poorly defined boundary and internal necrosis, heterogeneous persistent moderate enhancement with thickening blood supply arteries was seen in one malignant case with a long diameter of 150 mm and a thick diameter of 30 mm. Conclusions CT enhancement usually shows persistent obvious enhancement, especially in arterial phase, which provides important value for the diagnosis. CT findings can help in the differential diagnosis of GGT and other submucosal tumors.

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Section: Discussionmentioning

confidence: 99%

Computed tomography features and clinicopathological characteristics of gastric glomus tumor

et al. 2022

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“…There may be some areas of calcification and exhibit strong early-phase contrast enhancement [ 8 ]. However, radiological diagnosis can be challenging due to overlapping radiological features with other gastric submucosal lesions [ 9 ]. Differential diagnosis includes carcinoid tumor, hemangioma, GIST, leiomyoma, paraganglioma, lipoma, and other rare tumors.…”

Section: Discussionmentioning

confidence: 99%

Gastric Glomus Tumor: A Rare Cause of Acute Blood Loss Anemia

Mehmood¹,

Jamil²,

Khalid³

2022

Cureus

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Gastric glomus tumors (GGTs) are rare mesenchymal neoplasms that arise from cells of the glomus body. These occur in the submucosa of the gastric wall and are usually benign in nature. However, it is difficult to predict tumor behavior due to the lack of reliable histological features. Diagnosis can be challenging due to the lack of specific clinical features, and radiologic and endoscopic findings. Computed tomography (CT) scan, esophagogastroduodenoscopy (EGD), and endoscopic ultrasound (EUS) are key diagnostic modalities. However, the final diagnosis depends on the postoperative immunohistochemical and pathological analysis. Most GGTs can be cured by surgical or endoscopic resection. We report a case of GGT in a middle-aged woman who presented with new-onset anemia and was found to have a gastric mass that was later diagnosed as GGT after immunohistochemical staining.

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“…GT (glomangioma) as a benign solitary tumor mainly occurs in the extremities. Its appearance in the gastrointestinal tract is considered a rare entity [2,3,5] . The condition can be asymptomatic or may be associated with abdominal pain and gastrointestinal bleeding.…”

Section: Discussionmentioning

confidence: 99%

Gastric glomus tumor in a patient with biliary colic: a rare case report with literature review

Abdulla

Ali²,

Hassan³

et al. 2022

IJS Short Reports

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Introduction: Glomus tumor (GT) mainly occurs in the extremities. Its appearance elsewhere has rarely been reported. This study aims to report an incidental finding of gastric GT in a patient with biliary colic. Case presentation: A 45-year-old female presents with moderate to severe upper abdominal pain. Physical examination was performed, the abdomen was soft, nontender, and no mass felt. Transabdominal ultrasound showed a single stone in the gallbladder, normal wall thickness, and no biliary dilatation. The diagnosis of biliary colic was achieved based on the clinical presentation, examination findings, and test results. Wedge resection of the stomach with open cholecystectomy was performed. Histopathology result was compatible with gastric GT. Clinical discussion: The clinical examination of GT is much similar to other tumors like hemangioma, lipoma, gastrointestinal stromal tumor, and leiomyoma. Concerning diagnosis, GT is mostly intersecting with gastrointestinal stromal tumors, mainly in small biopsy screening. For this reason, most of the gastric GT can be identified preoperatively as gastrointestinal stromal tumors. Conclusion: Gastric GT is an uncommon benign tumor that can be found incidentally during the diagnosis of other diseases or tumors because of its clinical and radiologic similarities.

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Rare gastric neoplasm: Malignant glomus tumor of the stomach. A case report

Cited by 14 publications

References 20 publications

Computed tomography features and clinicopathological characteristics of gastric glomus tumor

Computed tomography features and clinicopathological characteristics of gastric glomus tumor

Gastric Glomus Tumor: A Rare Cause of Acute Blood Loss Anemia

Gastric glomus tumor in a patient with biliary colic: a rare case report with literature review

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