“…They exhibit an unusual resistance to thermal degradation, denaturants such as detergents, organic solvents and salts, and proteolytic cleavage (Chelikani et al, 2004). A slightly larger number of crystal structures have been published for clade 2 enzymes, including 12 from variants of Scytalidium thermophilum catalase (also known as catalasephenol oxidase or CATPO; Yuzugullu, Trinh, Fairhurst et al, 2013;Yuzugullu, Trinh, Smith et al, 2013;Yuzugullu Karakus et al, 2018;Goc et al, 2021), than for clade 1 enzymes (Dı ´az et al, 2012). It has been shown that clade 2 enzymes predominantly possess heme d, which is a cis-hydroxyspirolactone and an oxidized derivative of heme b (Dı ´az et al, 2012).…”