Ringing Decay of Gamma Oscillations and Transcranial Magnetic Stimulation Therapy in Autism Spectrum Disorder

Shaban, Mohamed; Ghazal, Mohammed; El-Baz, Ayman; Casanova, Manuel; Sokhadze, Estate M.

doi:10.1007/s10484-021-09509-z

Cited by 14 publications

(25 citation statements)

References 84 publications

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“…In such patients, inhibitory tone might have attenuated higher-order neural processing reflected in gamma-band activities. Gamma oscillatory neural activity is known to reflect inhibitory tone [ 1 , 2 ]. Inhibitory tone in the neural circuits is regulated through GABAergic inhibitory interneurons to balance the glutamatergic excitatory neurons [ 47 , 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

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The Association between Electroencephalography with Auditory Steady-State Response and Postoperative Delirium

Arai

Miyazaki

Nakajima

et al. 2022

JPM

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Delirium is a disorder of consciousness and a risk factor for cognitive dysfunction and poor prognosis. We hypothesized that preoperative gamma activities would be linked to postoperative delirium. We enrolled 71 subjects for elective surgery and recorded auditory steady-state response (ASSR) by electroencephalography (EEG) before the surgery and examined postoperative delirium with DSM-5. The EEG data were analyzed for baseline power, and ASSR evoked power (EP) and phase-locking factor (PLF) within the gamma range. Postoperative delirium was found in 18 patients (delirium group) but not in 53 patients (non-delirium group). There were no significant differences in the 40-Hz EP or PLF between the two groups. The baseline gamma activity negatively correlated with the 40-Hz PLF in the non-delirium group (ρ = −0.444, p < 0.01). The correlation between baseline gamma activity and 40-Hz EP was not significant in either the delirium or non-delirium group. In all patients, both preoperative PLF and EP had no significant correlations with the Delirium Rating Scale Revised-98 and the Memorial Delirium Assessment Measure at the post-operation, respectively. The disruption of the neurophysiological relationship between baseline gamma activity before sound stimuli and the PLF of the 40-Hz ASSR may be one of the potential neurophysiological indicators associated with postoperative delirium.

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Section: Discussionmentioning

confidence: 99%

“…Gamma oscillatory neural activity is known to reflect the balance between excitation and inhibition (E/I balance) [ 1 , 2 ]. The E/I imbalance in the neural circuits is suggested to be involved in the pathophysiology of major psychiatric disorders [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Electroencephalography with Auditory Steady-State Response and Postoperative Delirium

Arai

Miyazaki

Nakajima

et al. 2022

JPM

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“…Transcranial magnetic stimulation (TMS) can be applied as a therapeutic modality in ASD to restore the imbalance of excitation and inhibition, and modulate synaptic plasticity and gamma oscillations ( Oberman et al, 2016 ; Uzunova et al, 2016 ; Khaleghi et al, 2020 ; Casanova et al, 2021 ). A recent meta-analysis showed a moderate though significant effect of TMS on repetitive behaviors and core social dysfunction in ASD ( Barahona-Corrêa et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Excitation/Inhibition Modulators in Autism Spectrum Disorder: Current Clinical Research

Canitano

Palumbi

2021

Front. Neurosci.

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Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders characterized by social and communication abnormalities. Heterogeneity in the expression and severity of the core and associated symptoms poses difficulties in classification and the overall clinical approach. Synaptic abnormalities have been observed in preclinical ASD models. They are thought to play a major role in clinical functional abnormalities and might be modified by targeted interventions. An imbalance in excitatory to inhibitory neurotransmission (E/I imbalance), through altered glutamatergic and GABAergic neurotransmission, respectively, is thought to be implicated in the pathogenesis of ASD. Glutamatergic and GABAergic agents have been tested in clinical trials with encouraging results as to efficacy and tolerability. Further studies are needed to confirm the role of E/I modulators in the treatment of ASD and on the safety and efficacy of the current agents.

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“…Deficiencies in TBI research need to be emphasized to figure out solutions to reduce societal costs of TBI. Although many works have investigated the relationship between changes in gamma oscillations and abnormality in the nervous system (10)(11)(12), the interplay between gamma oscillations and TBI has yet to be confirmed. In general, changes in brain electrical activity occur after TBI (13,14).…”

Section: Introductionmentioning

confidence: 99%

40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat

Yang

Yuan

et al. 2022

Front. Neurol.

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BackgroundPhotobiomodulation (PBM) using low-level light-emitting diodes (LEDs) can be rapidly applied to various neurological disorders safely and non-invasively.Materials and MethodsForty-eight rats were involved in this study. The traumatic brain injury (TBI) model of rat was set up by a controlled cortical impact (CCI) injury. An 8-channel cortex electrode EEG was fixed to two hemispheres, and gamma oscillations were extracted according to each electrode. A 40 hz blue LED stimulation was set at four points of the frontal and parietal regions for 60 s each, six times per day for 1 week. Modified Neurologic Severity Scores (mNSS) were used to evaluate the level of neurological function.ResultsIn the right-side TBI model, the gamma oscillation decreased in electrodes Fp2, T4, C4, and O2; but significantly increased after 1 week of 40 hz Blue LED intervention. In the left-side TBI model, the gamma oscillation decreased in electrodes Fp1, T3, C3, and O1; and similarly increased after 1 week of 40 hz Blue LED intervention. Both left and right side TBI rats performed significantly better in mNSS after 40 hz Blue LED intervention.ConclusionTBI causes the decrease of gamma oscillations on the injured side of the brain of rats. The 40 hz Blue LED therapy could relieve the gamma oscillation changes caused by TBI and improve the prognosis of TBI.

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Ringing Decay of Gamma Oscillations and Transcranial Magnetic Stimulation Therapy in Autism Spectrum Disorder

Cited by 14 publications

References 84 publications

The Association between Electroencephalography with Auditory Steady-State Response and Postoperative Delirium

The Association between Electroencephalography with Auditory Steady-State Response and Postoperative Delirium

Excitation/Inhibition Modulators in Autism Spectrum Disorder: Current Clinical Research

40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat

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