A hazard evaluation of the reproductive/developmental toxicity of cobalt in medical devices

Monnot, Andrew D.; Kovochich, Michael; Bandara, Suren B.; Wilsey, Jared; Christian, Whitney V.; Eichenbaum, Gary; Perkins, Laura; Hasgall, Philippe; Taneja, M.; Connor, Kevin; Sague, Jorge; Nasseri-Aghbosh, Behrooz; Marcello, Stephen; Vreeke, Mark; Katz, Laurence B.; Reverdy, Edward E.; Thelen, Herbert A.; Unice, Kenneth M.

doi:10.1016/j.yrtph.2021.104932

Cited by 33 publications

(2 citation statements)

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“…Cobalt and its compound have higher allergic potential and cause allergic dermatitis. The disease symptoms due to higher levels of Co include heart and lung disease and allergic reactions [111][112][113]. Other symptoms of excess Co exposure include headache, high/low blood pressure, diarrhea, and frequent vomiting.…”

Section: Cobalt In the Human Bodymentioning

confidence: 99%

Cobalt in Soil-Plant-Human System: A Data-Analysis Review

Khalid,

Shahid,

Naz

et al. 2023

Preprint

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Cobalt (Co) is a transition metal and is classified as a beneficial metal for plants, but its benefits for plants remain obscure. Cobalt has been reported to negatively affect plant physiochemical processes both at higher (toxic) and lower (deficient) applied levels. High concentrations of cobalt in plant organs cause irreversible changes to the plant cells, mainly via enhanced production of reactive radicals. Moreover, Co and its compound play an essential role in humans as they are the central atoms of cobalamin, a co-enzyme precursor whose absence causes anemia. Hence, the optimum Co supply to plants is critical for customary plant metabolic workings. Henceforth, monitoring Co behavior in the soil-plant-human system is highly imperative. This review highlighted the latest literature on (i) Co in soil and plants; (ii) its mobility and phyto-availability in soil; (iii) phytouptake and translocation towards shoot tissues; (iv) toxic and deficient effects of Co on plants; (v) plant detoxification mechanisms under increased Co levels inside plants; and (v) its role in the human body. For this purpose, 1026 plant observations from literature data were analyzed related to Co biogeochemical behavior in the soil-plant system. The data analysis revealed an overall increase in 567 observations and a decrease in 381 observations. However, these general trends in plant responses vary significantly for different types of plant species and physiological attributes. Overall, the current review delineates an updated and critical representation of the biogeochemical behavior of Co in the soil-plant-human system, supported by up-to-date 9 main tables, 14 supporting tables, and 3 figures. The authors believe that the literature presented here can be of great interest to scientists, researchers, policymakers, and graduate-level students.

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Section: Cobalt In the Human Bodymentioning

confidence: 99%

Cobalt in Soil-Plant-Human System: A Data-Analysis Review

Khalid,

Shahid,

Naz

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…3,6 The clinical manifestation of cobalt intoxication includes various symptoms, such as skin reactions, hypothyroidism, testicular atrophy, and CNS toxicity, including vision and hearing impairment at higher concentrations as well as reversible but rapidly progressive cardiomyopathy with a high short-term mortality. 5,[7][8][9][10][11][12] In addition, possible cancer development, 13,14 and autoimmune, haematological and infectious diseases 15 were associated with high cobalt levels. The inhalation of cobalt-containing dust was related to occupational asthma, heavy metal pneumoconiosis, pulmonary brosis, and the aforementioned cardiomyopathy.…”

Section: Introductionmentioning

confidence: 99%