Effect of endogenous hormones, antisperm antibody and oxidative stress on semen quality of crossbred bulls

Gupta, Vinod Kumar; Srivastava, S. K.; Ghosh, SK; Srivastava, N.; Singh, Gyanendra; Verma, Med Ram; Katiyar, Rahul; Muthu, Ramamoorthy; Bhutia, Lhendup; Kumar, Abhishek; Singh, Rohit Kumar

doi:10.1080/10495398.2021.1905656

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Sperm quality has been shown to be negatively affected by ASAs (Ferrer and Miller, 2018;Gupta et al, 2021). As-sessing ASAs production may enable overcoming problems with sperms ejaculation, sperms travel, or production (Marconi and Weidner 2017).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Sperm Antibodies (ASAs) in the Serum and Seminal Plasma of Dromedary Male Camels with Infertility History

Albarrak¹,

Aldahmashi²,

Alrubayan³

et al. 2022

AAVS

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Anti-sperm antibodies (ASAs) have been shown to contribute to male infertility in multiple species but never been examined in male camels. We have developed and evaluated an ELISA assay to specifically detect and quantify ASAs in the serum and seminal plasma of 29 infertile dromedary male camels, which were of two different breeds (Waddah & Majaheem) and three different ages (> 3 to ≤5, ≥5 to ≤7, and >7 years). ASAs were detected in ≥ 80% of the examined animals with considerable individual variation within each group. The serum and seminal plasma ASAs indexes (%) were significantly elevated in the >7 years group compared to the >3 to ≤5 and ≥5 to ≤7 years groups (P ≤ 0.05), and in the ≥5 to ≤7 years group compared to the >3 to ≤5 years group (P ≤ 0.05). Serum and seminal plasma ASAs indexes were significantly higher in the Waddah breed compared to the Majaheem breed (P ≤ 0.05). The sperm motility and viability were significantly higher in the >7 years group compared to the > 3 to ≤5 years and ≥5 to ≤7 years groups (P ≤ 0.05 and P ≤ 0.01, respectively). Significant differences were also observed between the examined two breeds concerning sperm viability and motility with sperm viability being higher in the Majaheem breed (P ≤ 0.05) and sperm motility in the Waddah breed (P ≤ 0.05). Our data demonstrated the presence of ASAs in sera and seminal plasma of infertile dromedary male camels. Our results suggested that age and breed influenced serum and seminal plasma levels of ASAs in male camels. Data presented in the current study highlight the potential role of ASAs in camel infertility; however, more work is needed to determine ASAs' contribution to reproductive challenges in camels.

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Section: Resultsmentioning

confidence: 99%

Evaluation of Anti-Sperm Antibodies (ASAs) in the Serum and Seminal Plasma of Dromedary Male Camels with Infertility History

Albarrak¹,

Aldahmashi²,

Alrubayan³

et al. 2022

AAVS

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Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

Gupta,

Mohanty,

Bhakat

et al. 2023

Front. Vet. Sci.

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Infertility is one of the primary factors for cattle reproduction in the present scenario. Reproduction-related immunoinfertility mainly involves immunization against the antigens related to reproductive hormones (LHRH, GnRH, Gonadal steroids, PGF2α and oxytocin), spermatozoa, seminal plasma and ovum. Anovulation, delayed ovulation, sperm immobilization, failure of fertilization, prolonged uterine involution, extended calving interval, prolonged post-partum estrus and reduced conception rate could be a result of immunoinfertility that occur due to the blockage of receptor site by antibodies formed against hormones, sperm and ovum. Immunoinfertility can be treated in the animal by giving sexual rest to females, by using various reproductive technologies such as in-vitro fertilization, gamete intra fallopian tube transfer, and intracytoplasmic sperm injection, sperm washing and by treating the animals with immunomodulators such as LPS, Oyster glycogen, etc. This review summarizes the different causes of bovine reproductive immunoinfertility and amelioration strategies to overcome it.

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Effect of endogenous hormones, antisperm antibody and oxidative stress on semen quality of crossbred bulls

Cited by 2 publications

References 29 publications

Evaluation of Anti-Sperm Antibodies (ASAs) in the Serum and Seminal Plasma of Dromedary Male Camels with Infertility History

Evaluation of Anti-Sperm Antibodies (ASAs) in the Serum and Seminal Plasma of Dromedary Male Camels with Infertility History

Bovine reproductive immunoinfertility: pathogenesis and immunotherapy

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