Impaired theory of mind and emotion recognition in pediatric bipolar disorder: A systematic review and meta-analysis

Halac, Eren; Çıray, Remzi Oğulcan; Turan, Serkan; Tunçtürk, Mustafa; Ağaç, Nilay; Elmas, Fatma Nur; Rosson, Stella; Ermiş, Çağatay

doi:10.1016/j.jpsychires.2021.04.011

Cited by 8 publications

(3 citation statements)

References 62 publications

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“…It should be noted that small differences were found in reading processing speed abilities and total IQ levels ( 50 ). Halac et al ( 51 ) also demonstrated that children with BD presented with significantly worse social cognitive ability and emotional cognitive impairment even in euthymia, which was unrelated to age, gender, affective symptom severity, IQ level, comorbidity with ADHD, or drug treatment. Nieto et al ( 47 ) stated that the cognitive impairment in pediatric and adolescent patients with BD (such as language learning and memory, processing speed, and executive control) was similar but less severe than early-onset schizophrenia, which pointed to a mental disease continuous spectrum or represented some degree of genetic biooverlap.…”

Section: Clinical Manifestationmentioning

confidence: 97%

Research Status in Clinical Practice Regarding Pediatric and Adolescent Bipolar Disorders

et al. 2022

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Bipolar disorders (BDs) have high morbidity. The first onset of 27.7% of BDs occurs in children under 13 years and of 37.6% occurs in adolescents between 13 and 18 years. However, not all of the pediatric and adolescent patients with BD receive therapy in time. Therefore, studies about pediatric and adolescent patients with disorders have aroused increased attention in the scientific community. Pediatric and adolescent patients with BD present with a high prevalence rate (0.9–3.9%), and the pathogenic factors are mostly due to genetics and the environment; however, the pathological mechanisms remain unclear. Pediatric and adolescent patients with BD manifest differently from adults with BDs and the use of scales can be helpful for diagnosis and treatment evaluation. Pediatric and adolescent patients with BDs have been confirmed to have a high comorbidity rate with many other kinds of disorders. Both medication and psychological therapies have been shown to be safe and efficient methods for the treatment of BD. This review summarizes the research status related to the epidemiology, pathogenic factors, clinical manifestations, comorbidities, diagnostic and treatment scales, medications, and psychological therapies associated with BDs.

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Section: Clinical Manifestationmentioning

confidence: 97%

Research Status in Clinical Practice Regarding Pediatric and Adolescent Bipolar Disorders

et al. 2022

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“…Other studies have compared youths diagnosed with PBD and healthy controls. These suggest that patients diagnosed with PBD have deficits in cognition (Elias et al, 2017), social cognition (Halac et al, 2021), and emotion regulation (Khafif et al, 2021) and show increased amygdala reactivity to emotional stimuli relative to controls (Simonetti et al, 2022), though without any reliable structural differences in neuroimaging (Simonetti et al, 2022). Such studies, however, do not clearly address questions of aetiology or nosology.…”

Section: Laboratory Studiesmentioning

confidence: 97%

Paediatric bipolar disorder and its controversy

Connors

2022

Acta Neuropsychiatr.

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Objectives Paediatric bipolar disorder – bipolar disorder occurring in prepubertal children – is a diagnosis subject to considerable controversy. Whilst historically considered to be very rare, proponents since the 1990s have argued that mania can present differently in children and, as such, is much more common than previously thought. Such proposals raise questions about the validity of proposed phenotypes and potential risks of iatrogenic harm. Methods I critically examine the construct of paediatric bipolar disorder using Robins and Guze’s (1970) influential criteria for validity of a psychiatric diagnosis. I review, in turn, evidence relating to its clinical description, delimitation from other conditions, follow-up studies, family studies, laboratory studies, and treatment response. Results Across domains, existing research highlights significant challenges establishing the diagnosis. This includes significant heterogeneity in operationalising criteria for children; variable or poor inter-rater reliability; difficulty distinguishing paediatric bipolar disorder from other conditions; large differences in rates of diagnosis between the United States of America and other countries; limited evidence of continuity with adult forms; and a lack of evidence for proposed paediatric phenotypes in children at genetic high-risk of the condition. Laboratory and treatment studies are limited, but also do not provide support for the construct. Conclusions Evidence for the more widespread existence of paediatric bipolar disorder and its various proposed phenotypes remains weak. The ongoing popularity of the diagnosis, most evident in America, may reflect social pressures and broader limitations in psychiatric nosology. The uncertainty around the diagnosis highlights the need for careful longitudinal assessment of children potentially affected.

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“…Higher scores indicate better quality. We used a cut-off value of ≥7 to define low risk of bias (45,46).…”

Section: Risk Of Bias Assessmentmentioning

confidence: 99%

Performance in emotion recognition and theory of mind tasks in social anxiety and generalized anxiety disorders: a systematic review and meta-analysis

Baez,

Tangarife,

Davila-Mejia

et al. 2023

Front. Psychiatry

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Social cognition impairments may be associated with poor functional outcomes, symptoms, and disability in social anxiety disorder (SAD) and generalized anxiety disorder (GAD). This meta-analysis aims to determine if emotion recognition and theory of mind (ToM) are impaired in SAD or GAD compared to healthy controls. A systematic review was conducted in electronic databases (PubMed, PsycNet, and Web of Science) to retrieve studies assessing emotion recognition and/or ToM in patients with SAD or GAD, compared to healthy controls, up to March 2022. Meta-analyses using random-effects models were conducted. We identified 21 eligible studies: 13 reported emotion recognition and 10 ToM outcomes, with 585 SAD patients, 178 GAD patients, and 753 controls. Compared to controls, patients with SAD exhibited impairments in emotion recognition (SMD = −0.32, CI = −0.47 – −0.16, z = −3.97, p < 0.0001) and ToM (SMD = −0.44, CI = −0.83 –0.04, z = −2.18, p < 0.01). Results for GAD were inconclusive due to the limited number of studies meeting the inclusion criteria (two for each domain). Relevant demographic and clinical variables (age, sex, education level, and anxiety scores) were not significantly correlated with emotion recognition or ToM impairments in SAD and GAD. Further studies employing ecological measures with larger and homogenous samples are needed to better delineate the factors influencing social cognition outcomes in both SAD and GAD.

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Impaired theory of mind and emotion recognition in pediatric bipolar disorder: A systematic review and meta-analysis

Cited by 8 publications

References 62 publications

Research Status in Clinical Practice Regarding Pediatric and Adolescent Bipolar Disorders

Research Status in Clinical Practice Regarding Pediatric and Adolescent Bipolar Disorders

Paediatric bipolar disorder and its controversy

Performance in emotion recognition and theory of mind tasks in social anxiety and generalized anxiety disorders: a systematic review and meta-analysis

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