Intravenous tPA Delays Door-To-Puncture Time in Acute Ischemic Stroke with Large Vessel Occlusion

Atchaneeyasakul, Kunakorn; Desai, Shashvat M; Malhotra, Konark; Dolia, Jaydevsinh; Shah, Kavit; Saver, Jeffrey L.; Jovin, Tudor G; Jadhav, Ashutosh P.

doi:10.1016/j.jstrokecerebrovasdis.2021.105732

Cited by 9 publications

(1 citation statement)

References 15 publications

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“…Clinically, vascular recanalization is an effective treatment for IS. Although tPA is considered an effective drug against IS, it is difficult for most patients to reach hospital within its optimal use time (Atchaneeyasakul et al, 2021). Therefore, the development of new treatment strategies for IS remains extremely important.…”

Section: Discussionmentioning

confidence: 99%

A new peptide alleviates cerebral ischemia-reperfusion injury by restricting oxidative stress and endoplasmic reticulum stress

Liu,

Li,

Yang

et al. 2024

Preprint

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Background and Purpose: Ischemia reperfusion (I/R) is the main cause of acute ischemic stroke injury. However, existing treatments for I/R injury are relatively poor, and relevant drugs need to be further explored. Experimental Approach: In this study, the neuroprotective function and related mechanism of OL-FS13 were studied through rat I/R model and PC12 cell model of oxygen glucose deprivation/reoxygenation model (OGD/R), combined with cell viability experiment, tissue H&E and Nissl staining experiment and Western blot experiment. Key Results: In this study, we identified a novel neuroprotective peptide (OL-FS13, amino acid sequence: FSLLLTWWRRRVC) from the odorous frog species Odorrana livida using a constructed cDNA library. OL-FS13 significantly alleviated brain injury from cerebral I/R in rats by reducing infarct volume in the brain, improving behavioral and histological abnormalities, and rescuing PC12 cell from damage caused by oxygen glucose deprivation/reoxygenation (OGD/R). Mechanistically, OL-FS13 increased the level of antioxidative enzymes to resist oxidative stress induced by I/R and OGD/R by activating the Nrf2/HO-1 pathway and alleviated endoplasmic reticulum (ER) stress induced by OGD/R by inhibiting the IRE1α/TRAF2/JNK pathway. Conclusion and Implications: Collectively, the novel peptide exerted significant anti-stroke activities by alleviating oxidative and ER stress via activation of Nrf2 signaling and suppression of the IRE1α/TRAF2/JNK pathway. Thus, this research provides a potential drug candidate for the clinical treatment of cerebral I/R.

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Section: Discussionmentioning

confidence: 99%