Tackling Food Allergy in Infancy

Devonshire, Ashley; Lin, Adora A.

doi:10.1016/j.iac.2021.01.008

Cited by 4 publications

(2 citation statements)

References 101 publications

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“…Degranulation results in the release of preformed substances, such as histamine and tryptase, and rapid synthesis of lipid mediators and cytokines that lead to the rapid development of clinical symptoms [4,5]. These symptoms can manifest differently based on the age of the child (Table 1) [6,7 ▪ ,8]. The most severe form of an IgE-mediated food-induced reaction is anaphylaxis, which simultaneously involves multiple organ systems and is potentially fatal [9].…”

Section: Ige-mediated Food Allergymentioning

confidence: 99%

“…Degranulation results in the release of preformed substances, such as histamine and tryptase, and rapid synthesis of lipid mediators and cytokines that lead to the rapid development of clinical symptoms [4,5]. These symptoms can manifest differently based on the age of the child (Table 1) [6,7 anaphylaxis, which simultaneously involves multiple organ systems and is potentially fatal [9]. Although fatalities from allergic reactions to food are rare, they are more common in the second to third decade of life [10].…”

Section: Ige-mediated Food Allergymentioning

confidence: 99%

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B cells and food allergy

Udemgba

Lin

2021

Current Opinion in Pediatrics

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Purpose of review B cells are known in food allergy pathogenesis for their production of IgE but their roles in the development of tolerance to foods are not well understood. Further understanding of B-cell biology in the context of food allergy is essential for the creation of effective prevention strategies and therapies. Recent findings The majority of allergen-specific IgE in humans appears to arise from antigen-experienced B cells that have already undergone class switch recombination to other antibody isotypes, such as IgG1, and can also be produced by cells class switching to IgE locally in the gastrointestinal tract. Allergen-specific IgG4 can have protective effects in individuals and is associated with tolerance. Regulatory B cells, which can produce allergen-specific IgG4, are reduced in food-allergic individuals and may also be an important component of tolerance. Therapeutic approaches that block the generation and action of IgE and that enhance tolerizing immune responses are being evaluated for the treatment of food allergy. Summary B cells play several roles in the development of food allergy versus tolerance. Their functions may translate into the care of food allergy as biomarkers or therapeutic targets and can be employed in other atopic diseases to better understand their pathogenesis and create new avenues for treatment.

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Section: Ige-mediated Food Allergymentioning

confidence: 99%

“…Degranulation results in the release of preformed substances, such as histamine and tryptase, and rapid synthesis of lipid mediators and cytokines that lead to the rapid development of clinical symptoms [4,5]. These symptoms can manifest differently based on the age of the child (Table 1) [6,7 anaphylaxis, which simultaneously involves multiple organ systems and is potentially fatal [9]. Although fatalities from allergic reactions to food are rare, they are more common in the second to third decade of life [10].…”

Section: Ige-mediated Food Allergymentioning

confidence: 99%

B cells and food allergy

Udemgba

Lin

2021

Current Opinion in Pediatrics

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“Where are they now?” Catching up with the 2018 AAAAI Faculty Development Awardees

Ballas¹

2023

Journal of Allergy and Clinical Immunology

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Unraveling the diet-dermatitis connection: A systematic review of dietary exclusion in children with atopic dermatitis

Msuya,

Srivastava

2024

CSDM

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This review focuses on atopic dermatitis (AD) impacting 10–30% of children and influenced by food and aeroallergens. It highlights the need for cautious interpretation of sensitization to foods, as it does not guarantee allergy and the potential harm of indiscriminate avoidance affecting nutrient intake. Tests such as skin prick tests, serum-specific immunoglobulin E tests, and food challenges are essential before implementing food elimination. The objective is to assess current dietary exclusion practices in AD children. By screening eight studies including randomized controlled trials, systematic reviews, and cohort studies, the review underscores the benefits of evidence-based dietary exclusion for moderate to severe cases. It establishes causal links between food allergy (FA) and AD emphasizing evidence-based dietary modification over blanket elimination. Temporal changes in allergen antigenicity also suggest evidence-based, supervised practices. In conclusion, the review supports the benefits of evidence-guided food exclusion for AD with 50% of studies backing moderate-to-severe cases. It highlights the need for robust trials to guide rational food restriction, ultimately aiding patients and parents.

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Tackling Food Allergy in Infancy

Cited by 4 publications

References 101 publications

B cells and food allergy

B cells and food allergy

“Where are they now?” Catching up with the 2018 AAAAI Faculty Development Awardees

Unraveling the diet-dermatitis connection: A systematic review of dietary exclusion in children with atopic dermatitis

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