Recurrent Aphthous Stomatitis Improved after Eradication Therapy for Helicobacter pylori

Abstract

Helicobacterpylori (H. pylori) is a Gram-negative bacterium that colonizes gastric mucosa and is often transmitted through direct contact with saliva, contaminated food or water, and vomit. The majority of the infected individuals remain asymptomatic for a long period. Infection with H. Pylori often presents with dyspepsia, nausea, frequent belching, bloating, abdominal discomfort, burning abdominal pain, and peptic ulcer. A potential association between H. Pylori and recurrent aphthous stomatitis was previously reported; however, the presence of causative relationship between the two remained controversial. We are presenting a case of recurrent aphthous stomatitis of twenty-four-year history resolved after H. pylori treatment.

Helicobacter pylori and unignorable extragastric diseases: Mechanism and implications

“…Recurrent aphthous stomatitis (RAS) is regarded as a recurrent painful ulcerative disease that regularly impacts mucosa in the oral cavity. Gao et al (2021) reported a RAS case with a history of 24 years that was cured after treatment for H. pylori , indicating that eradication of H. pylori might relieve RAS symptoms and is a promising RAS therapy.…”

Evaluation of novel topical camel whey protein gel for the treatment of recurrent aphthous stomatitis: Randomized clinical study

“…Recurrent aphthous stomatitis (RAS) disorder is a popular common recurrent chronic inflammatory disease characterized by painful ulcerations affecting the oral mucous membrane usually at lingual, buccal, and labial mucosa. [ 1 ]…”