Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro

Ding, Tao; Zhao, Tingting; Li, Yinhui; Liu, Zhixiao; Ding, Jiarong; Ji, Boyao; Wang, Yue; Guo, Zhiyong

doi:10.1016/j.phymed.2021.153562

Cited by 42 publications

(38 citation statements)

References 25 publications

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“…Ohwi (Zhang 2019). Puerarin exhibits a wide range of antioxidant activities in cardiovascular diseases, diabetes, obesity, osteoporosis, and other diseases (Xu et al, 2021;Chang et al, 2021;Liu Y. et al, 2021;Xiao et al, 2020). In addition, puerarin has anti-inflammatory, anti-viral and other pharmacological activities (Wang Z.-K. et al, 2020;Wang H. X. et al, 2021).…”

Section: Puerarinmentioning

confidence: 99%

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Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Pang

et al. 2021

Front. Pharmacol.

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Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.

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Section: Puerarinmentioning

confidence: 99%

“…, bamboo, etc ( He et al, 2016 ). It has many pharmacological activities, anti-inflammatory, antiviral, anticancer, antihypertensive ( Ding et al, 2021 ; Chen Y. et al, 2021 ). At the same time, Vitexin is an antioxidant ( Ożarowski and Karpiński 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Pang

et al. 2021

Front. Pharmacol.

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“…Several researchers have reported, in vitro, the effect of catechin, resveratrol, epicatechin, hesperidin, hesperitin, and quercetin on the prevention of urolithiasis formation, using crystallization processes, artificial urine, and crystal development in cellular assays [10][11][12]16,[18][19][20][21][22][23][24].…”

Section: In Vitro Investigationsmentioning

confidence: 99%

“…The anti-lithiasis effect of rutin, apigenin, catechin, curcumin, resveratrol, and quercetin was reported by several investigators (Tables 1 and 2) using several animal models, as well as the oral administration of ethylene glycol (EG), EG with vitamin D3, EG with ammonium chloride, an oxalate rich diet, and MCM in rats [9][10][11][13][14][15][17][18][19][20][22][23][24].…”

Section: In Vivo Investigationsmentioning

confidence: 99%

“…The nephrolithiasis effect of rutin was evaluated in EG-induced CaOx urolithiasis in rats [15,22]. At 20 mg/kg for 28 days, the calcium and oxalate levels in urine and kidney tissues were reduced compared to lithiasis rats (0.35 mg/day vs. 0.86 mg/day and 11.70 mg/day vs. 21.26 mg/day, respectively in urine, and 0.18 mg/g vs. 0.27 mg/g and 7.73 mg/g vs. 11.46 mg/g, respectively in kidneys).…”

Section: Rutinmentioning

confidence: 99%

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Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

et al. 2021

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Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

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A pyroptosis‐related signature predicts prognosis and indicates immune microenvironment infiltration in glioma

Chen

et al. 2022

Cancer Medicine

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Background Glioma, the most common malignant brain tumor, leads to high recurrence rates and disabilities in patients. Pyroptosis is an inflammasomes‐induced programmed cell death in response to infection or chemotherapy. However, the role of pyroptosis in glioma has not yet been elucidated. Methods RNA‐seq data and clinical information of 660 gliomas and 847 samples were downloaded from the TCGA and CGGA, respectively. Then, data of 104 normal brain tissues was retrieved from the GTEx for differential expression analysis. Twelve pairs of peritumoral tissue and glioma samples were used for validation. Gene alteration status of differentially expressed pyroptosis‐related regulators in gliomas was detected in cBioPortal algorithm. Consensus clustering was employed to classify gliomas based on differentially expressed pyroptosis‐related regulators. Subsequently, a PS‐signature was constructed using LASSO‐congressional analysis for clinical application. The immune infiltration of glioma microenvironment (TME) was explored using ESTIMATE, CIBERSORT, and the other immune signatures. Results cBioPortal algorithm revealed alteration of these regulators was correlated to better prognosis of gliomas. Then, our study showed that pyroptosis‐related regulators can be used to sort out patients into two clusters with distinct prognostic outcome and immune status. Moreover, a PS‐signature for predicting the prognosis of glioma patients was developed based on the identified subtypes. The high PS‐score group showed more abundant inflammatory cell infiltration and stronger immune response, but with poorer prognosis of gliomas. Conclusion The findings of this study provide a therapeutic basis for future research on pyroptosis and unravel the relationship between pyroptosis and glioma prognosis. The risk signature can be utilized as a prognostic biomarker for glioma.

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Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro

Cited by 42 publications

References 25 publications

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

A pyroptosis‐related signature predicts prognosis and indicates immune microenvironment infiltration in glioma

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