The aging brain: sleep, the circadian clock and exercise

Panagiotou, Maria; Michel, Stephan; Meijer, Johanna H.; Deboer, Tom

doi:10.1016/j.bcp.2021.114563

Cited by 30 publications

(18 citation statements)

References 140 publications

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“…Aging can be characterized as a time-dependent process of losing organic functions, and the brain is not spared. Sleep, dependent on several pathways and mechanisms, also has its full functioning altered [4]. The ability to initiate and maintain sleep is compromised, and the electroencephalogram shows less deep sleep.…”

Section: Introductionmentioning

confidence: 99%

“…The ability to initiate and maintain sleep is compromised, and the electroencephalogram shows less deep sleep. These changes may be associated with reduced white matter density, reduced gray matter volume in some regions, diminishment in functional synapses and impact on the production and degradation of neurotransmitters and neuropeptides [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Physical Exercise on Sleep Quality in Elderly Adults: A Systematic Review with a Meta-Analysis of Controlled and Randomized Studies

Silva

et al. 2022

JAL

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Introduction: Aging is directly related to sleep problems. Primary insomnia has a negative impact on the lives of elderly adults, altering cognitive and metabolic functions. Physical activity is positively related to improvement in sleep quality. The objective of this systematic review was to analyze the effects of physical activity programs in healthy elderly individuals aged 60 years or older, using the Pittsburgh Sleep Quality Index (PSQI) as a tool. Methods: The search was performed in the PubMed and Scielo databases, July 2021. Only randomized clinical trials that evaluated the role of physical exercise in the sleep quality of elderly patients were selected by two independent reviewers. Results: The result of the PSQI analysis showed that compared with the control condition, the exercise intervention was beneficial for the groups with insomnia (SMD: −0.57; 95% CI: −0.73 to −0.4; p < 0.00001; I2 = 53%) and without insomnia (SMD: −0.61; 95% CI: −0.75 to −0.47; p < 0.00001; I2 = 73%) and for the two groups combined (SMD: −0.59; 95% CI: −0.70 to −0.49; p < 0.0001, I2 = 68%). Conclusion: The systematic and continuous practice of physical exercise significantly improves perceived sleep quality in elderly individuals. Therefore, physical activities can be used as a tool to prevent sleep disorders and improve health in general. Future studies may clarify the comparison between aerobic and resistance exercises, evaluate the dose–response relationship and include more participants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Physical Exercise on Sleep Quality in Elderly Adults: A Systematic Review with a Meta-Analysis of Controlled and Randomized Studies

Silva

et al. 2022

JAL

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“…Aging is associated with detrimental changes in the circadian time keeping machinery ( Panagiotou et al, 2021 ), and linked to the pathologies mentioned above. Elucidating the mechanisms underlying aging-induced circadian dysfunction is thus extremely important.…”

Section: Making Biological Time: the Molecular And Neural Circuits Me...mentioning

confidence: 99%

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

et al. 2022

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A variety of organisms including mammals have evolved a 24h, self-sustained timekeeping machinery known as the circadian clock (biological clock), which enables to anticipate, respond, and adapt to environmental influences such as the daily light and dark cycles. Proper functioning of the clock plays a pivotal role in the temporal regulation of a wide range of cellular, physiological, and behavioural processes. The disruption of circadian rhythms was found to be associated with the onset and progression of several pathologies including sleep and mental disorders, cancer, and neurodegeneration. Thus, the role of the circadian clock in health and disease, and its clinical applications, have gained increasing attention, but the exact mechanisms underlying temporal regulation require further work and the integration of evidence from different research fields. In this review, we address the current knowledge regarding the functioning of molecular circuits as generators of circadian rhythms and the essential role of circadian synchrony in a healthy organism. In particular, we discuss the role of circadian regulation in the context of behaviour and cognitive functioning, delineating how the loss of this tight interplay is linked to pathological development with a focus on mental disorders and neurodegeneration. We further describe emerging new aspects on the link between the circadian clock and physical exercise-induced cognitive functioning, and its current usage as circadian activator with a positive impact in delaying the progression of certain pathologies including neurodegeneration and brain-related disorders. Finally, we discuss recent epidemiological evidence pointing to an important role of the circadian clock in mental health.

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“…In rodent models, as reviewed by Panagiotou et al (2021) , it has been demonstrated that even moderate age-matched exercise is able to ameliorate several aging features, as far as sleep and circadian rhythms are concerned, independently from the species under investigation. It should be underscored that the technological nature of modern society, with round-the-clock work schedules has had a negative impact, leading to an increase in the incidence of circadian and sleep disorders.…”

Section: Epigenetic and Circadian Clocksmentioning

confidence: 99%

The Frailty Puzzle: Searching for Immortality or for Knowledge Survival?

Govoni

Fagiani

Lanni

et al. 2022

Front. Cell. Neurosci.

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What is the value of assessing the biological age and frailty and predicting residual lifespan and health status? The benefit is obvious if we have means to alter the pace of aging and the development of frailty. So far, limited but increasing examples of interventions altering the predicted status indicate that, at least in some cases, this is possible through interventions spanning from the economic-social through drug treatments. Thus, why searching for biological markers, when some clinical and socio-economic indicators do already provide sufficiently accurate predictions? Indeed, the search of frailty biomarkers and of their biological clocks helps to build up a mechanistic frame that may orientate the design of interventions and the time window of their efficacy. Among the candidate biomarkers identified, several studies converge to indicate epigenetic clocks as a promising sensitive biomarker of the aging process. Moreover, it will help to establish the relationship between personal aging and health trajectories and to individuate the check points beyond which biological changes are irreversible.

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The aging brain: sleep, the circadian clock and exercise

Cited by 30 publications

References 140 publications

Effect of Physical Exercise on Sleep Quality in Elderly Adults: A Systematic Review with a Meta-Analysis of Controlled and Randomized Studies

Effect of Physical Exercise on Sleep Quality in Elderly Adults: A Systematic Review with a Meta-Analysis of Controlled and Randomized Studies

It’s About Time: The Circadian Network as Time-Keeper for Cognitive Functioning, Locomotor Activity and Mental Health

The Frailty Puzzle: Searching for Immortality or for Knowledge Survival?

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