Food restriction reduces hepatic alterations associated with experimental periodontitis

Caetano, Vinícius da Silva; Andrade, Raíssa Silva Bacelar de; França, Luíz Felipe de Carvalho; Pessoa, Larissa dos Santos; Rodrigues, Ayane Araújo; Alves, Even Herlany Pereira; Lenardo, David Di; Nascimento, Hélio Mateus Silva; Ayala, Karen Neisman Rodriguez; Carvalho, André dos Santos; Brito, Tarcísio Vieira de; Barbosa, André Luiz dos Reis; Vasconcelos, Any Carolina Cardoso Guimarães; Vasconcelos, Daniel Fernando Pereira

doi:10.1002/jper.20-0772

Cited by 4 publications

(4 citation statements)

References 43 publications

(53 reference statements)

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“…The activation of caspase family proteins is an important sign of apoptosis. Therefore, an activity assay was used to detect the effect of DhHP-6 on HGFs [ 29 ]. As shown in Figure 1 D, the activity levels of caspase-3, caspase-8, and caspase-9 in cells treated with DhHP-6 + H 2 O 2 were significantly lower than those in cells treated with H 2 O 2 alone.…”

Section: Resultsmentioning

confidence: 99%

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Deuterohemin-Ala-His-Thr-Val-Glu-Lys (DhHP-6) Mimicking Enzyme as Synergistic Antioxidant and Anti-Inflammatory Material for Periodontitis Therapy

et al. 2022

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Periodontitis is an inflammatory disease induced by plaque microorganisms. In the clinic, antibiotic assistant periodontal mechanical therapy is the most effective therapy for the treatment of periodontitis. However, the drug resistance of the antibiotics and the repeated coming and diminishing of the disorder of oxidation–reduction balance in the inflammatory tissue could not meet the high requirements for periodontic health control in long periods. Deuterohemin-ala-his-thr-val-glu-lys (DhHP-6) is a biomimetic oxidase-mimicking enzyme that simulates the reactive oxygen radical scavenger function of heme by synthesizing the new molecular material following the key structure and amino acid sequence of heme. In this article, we report the antioxidant and anti-inflammatory properties of DhHP-6 by building a inflammatory model for human gingival fibroblasts (HGFs) stimulated by lipolysaccharide (LPS) and its effects on periodontitis in Wistar rats. DhHP-6 reduced the oxidative stress of HGFs by increasing the amount of the reductase species of glutathione (GSH) and catalase (CAT) while decreasing the amount of oxidase species of malonaldehyde (MDA) and reactive oxygen species (ROS). DhHP-6 had a dose-dependent protective effect on alveolar bone absorption in rats with periodontitis, enhanced antioxidant capacity, and reduced inflammation. As determined by Micro-CT scanning, DhHP-6 reduced alveolar bone loss and improved the bone structure of the left maxillary first molar of rats. There were no obvious morphological and histological differences in the rat organs with or without DhHP-6 treatment. These results suggest that DhHP-6 can be used to treat periodontitis by increasing the expression levels of antioxidant enzymes and antioxidants in systemic and local tissues, thereby reducing levels of oxidation products and cyto-inflammatory factors. The synergistic antioxidant and anti-inflammatory effects of DhHP-6 suggest that there are promising applications of this biomimetic enzyme molecular material for the next generation of agents for periodontitis therapy.

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Section: Resultsmentioning

confidence: 99%

“…Previous studies have shown that DhHP-6 has anti-inflammatory effects as a peroxidase-mimicking enzyme. Our results indicated that DhHP-6 has therapeutic effects in periodontitis by reducing the levels of the inflammatory factors TNF-α and IL-1β in HGFs sensitized by LPS and reducing the cellular inflammatory response [ 29 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Deuterohemin-Ala-His-Thr-Val-Glu-Lys (DhHP-6) Mimicking Enzyme as Synergistic Antioxidant and Anti-Inflammatory Material for Periodontitis Therapy

et al. 2022

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“…[88] One study found that food restriction in rats reduced oral damage as well as alveolar bone changes hepatic, blood, and associated with ligature-induced periodontitis. [89] In a ligature-induced periodontitis model study, bromelain was administrated to rats. It was shown that bromelain improved the steatosis scores.…”

Section: Periodontal Problems and Non-alcoholic Fatty Liver Diseasementioning

confidence: 99%

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

Hatipoglu

2024

J Inonu Liver Transpl Inst

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T he Non-alcoholic fatty liver disease (NAFLD) it's a term used for several conditions caused by fat accumulation in the liver. One-fourth of the world's population is faced with this clinical situation. It is mostly seen in South America and the Middle East, and least in Africa. [1] Nevertheless, when considering its prevalence within the community, this malady emerges as one of the most frequently encountered liver diseases, demonstrating a notable association with elevated rates of liver-related mortality and morbidity. [2] By definition, NAFLD is a clinical picture in which insulin resistance, histopathological more than 5% steatosis of hepatocytes, or dense fat fractions by radiographic techniques are detected. This clinical situation is examined under two main headings non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (steatosis coexists with liver-cell injury and inflammation). [3,4] NAFLD has 4 stages for developing; simple fatty liver (steatosis), non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and may liver cancer. [5] In advanced phases, this may result in liver transplantation. The patients with NAFLD show similar histological damage to alcoholic liver disease. [6] Oxidative and inflammatory responses play crucial roles in the shared pathogenesis of both NAFLD and nonalcoholic NASH. [7] Lifestyle is an important point for developing this disease.Periodontal disease is a common inflammatory disease and is known to be related to other systemic diseases. This bidirectional relation between periodontal disease and other disease processes has led to outstanding research recently. In addition, periodontal disease has been advocated to exacerbate metabolic disorders including non-alcoholic fatty liver disease (NAFLD). In this traditional review, general characteristics of periodontal diseases, general characteristics of NAFLD/ Nonalcoholic steatohepatitis (NASH), and their causality were discussed for treatment providers. The collected data significantly corroborate a greater incidence of periodontal disease among individuals with NAFLD in comparison to the general healthy population. Healthcare professionals need to be aware of the association between NAFLD and periodontal disease thus patient management effectiveness can be enhanced.

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“…Recent studies have shown an association between NAFLD and CP 10 . On the other hand, some observational and experimental studies have suggested a potential link between CP and NAFLD 11,12 . However, the previously published studies have limitations in evaluating the causal effects, which require controlling the biases and confounding factors.…”

Section: Introductionmentioning

confidence: 99%

A Mendelian randomization study between chronic periodontitis and non‐alcoholic fatty liver disease

Tan,

He,

Wang

et al. 2023

J of Periodontal Research

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Background and ObjectiveObservational studies have suggested a potential association between non‐alcoholic fatty liver disease (NAFLD) and chronic periodontitis (CP). However, these studies are prone to confounding factors. The aim of this study was to assess the causal relationship between NAFLD and CP using a two‐sample bidirectional Mendelian randomization (MR) analysis method.MethodsDatasets of CP and NAFLD were retrieved from the European database, and instrumental variables (IVs) related to exposure were selected for the MR analysis. Sensitivity tests, including heterogeneity and horizontal pleiotropy tests, were conducted to ensure the consistency of the selected IVs, following which the analysis results were visualized.ResultsGenetic variants associated with CP and NAFLD were identified as IVs, and the MR assessment was performed using the summary data (CP: 3046 cases and 195 395 controls; NAFLD: 894 cases and 217 898 controls). CP increased the risk of NAFLD (inverse variance weighted [IVW], b = 0.132 > 0, p = .006 < .05), whereas the reverse was not observed (IVW, b = −0.024 < 0, p = .081 > .05). The sensitivity analysis indicated no heterogeneity or horizontal pleiotropy.ConclusionThe MR analysis suggested that CP could increase the risk of NAFLD among European populations.

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Food restriction reduces hepatic alterations associated with experimental periodontitis

Cited by 4 publications

References 43 publications

Deuterohemin-Ala-His-Thr-Val-Glu-Lys (DhHP-6) Mimicking Enzyme as Synergistic Antioxidant and Anti-Inflammatory Material for Periodontitis Therapy

Deuterohemin-Ala-His-Thr-Val-Glu-Lys (DhHP-6) Mimicking Enzyme as Synergistic Antioxidant and Anti-Inflammatory Material for Periodontitis Therapy

Non-Alcoholic Fatty Liver and Periodontal Disease: Is there a Relationship? A Contemporary Review

A Mendelian randomization study between chronic periodontitis and non‐alcoholic fatty liver disease

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